Ethan Goddard-Borger

The 2025 chemistry Nobel goes to MOFs Susumu Kitagawa, Richard Robson and Omar M. Yaghi win the prize for developing metal–organic frameworks

The 2025 #NobelPrize in Chemistry has been awarded to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal–organic frameworks.” Stay tuned for the full story to come! cen.acs.org/people/nobel...

#ChemNobel #Chem #Chemistry #chemsky 🧪

Dear Everyone, I've read the #NHMRC draft strategy and I have notes ...

So I'm going to...🧵🤔🧵😱🧵😵‍💫🧵🙏🧵🧵🧵
This is a repost from X because you all need to know!

#NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience

@nhmrc.bsky.social

Convergent Lead Discovery Strategies Yield Covalent and Non-covalent Inhibitors of Human UDP-Galactose-4-Epimerase O-GalNAc (N-acetylgalactosaminyl) glycosylation is an abundant posttranslational modification in mammalian cells. Dysregulation of O-GalNAc glycosylation is implicated in cancer metastasis and immune ...

Check out our new preprint "Convergent Lead Discovery Strategies Yield Covalent and Non-covalent Inhibitors of Human UDP-Galactose-4-Epimerase" on Chemrxiv led by Will Browne in close collab with GSK @jtbush.bsky.social

chemrxiv.org/engage/chemr...

Inspiring work Ben and team!

ProteinDJ logo

I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5)
doi.org/10.1101/2025.09.24.678028 #proteindesign

Reshaping of a Glycoside Hydrolase Active Site through Expression-Compensated Droplet-Based Microfluidic Screening Provides Useful Tools for Glycomics The glycosylation of proteins endows them with distinct biophysical properties and allows them to play fundamental roles in cellular communication. Much of our understanding of glycoproteins has deriv...

Beautiful enzyme evolution work by Steve Withers and coworkers 👏

pubs.acs.org/doi/10.1021/...

Very exciting to see the @wehi-research.bsky.social PINK1 Parkinson’s Disease research team win the Eureka Prize for Scientific Research. Amazing achievement by a brilliant team! @eurekaprizes.bsky.social

Congratulations!

📸 L–R: Professor David Komander, Dr Nicholas Kirk, Dr Sylvie Callegari and Dr Alisa Glukhova. 

Researchers from WEHI’s Parkinson Disease Research Centre have won the 2025 UNSW Eureka Prize for Scientific Research. The team has been honoured for their research unravelling how PINK1, a key protein linked to early-onset Parkinson’s disease, works.

🔗 www.wehi.edu.au/news/eureka-...

The Institute for Molecular Bioscience is seeking an exceptional academic leader to be the new Director of the Centre for Chemistry and Drug Discovery and lead our centre consisting of 10 group leaders, 40 staff and approximately 50 HDR students. Come and join us in sunny Brisbane!

Congratulations everyone!

Last but most certainly not least, The President’s Innovator Award 2025 goes to
Dr. Nicki Packer, Macquarie University, Sydney, Australia 👏🥂👏🥂

Structure-guided phage display discovery of antibodies for (S)Tn-glycans in protein context - Nature Chemical Biology Structural studies of certain Tn and STn antigen-targeting antibodies reveal that their VH and VL domains recognize the glycan antigen and the adjacent peptide region, respectively, enabling a VH doma...

#glycotime #immunology Structure-guided design rules for antibodies targeting cancer antigens with Tn and STn epitopes

www.nature.com/articles/s41...

YouTube video by Australian Museum PINK1 Parkinson's Disease Research Team – Finalist, 2025 Eureka Prize for Scientific Research

🎉 What an honour to be a finalist in the 2025 Australian Museum Eureka Prizes for Scientific Discovery!! With David Komander, @zhongyangan.bsky.social, Alisa Glukhova and @nskirk.bsky.social.

Excited for the awards ceremony on Sept 3rd!

@eurekaprizes.bsky.social
@wehi-research.bsky.social

ChimeraX daily builds can predict binding affinity of small molecules using Boltz 2 on your Mac, Windows or Linux computer. www.rbvi.ucsf.edu/chimerax/dat...

Introducing Latent-X — our all-atom frontier AI model for protein binder design.

State-of-the-art lab performance, widely accessible via the Latent Labs Platform.

Free tier: platform.latentlabs.com
Blog: latentlabs.com/latent-x/
Technical report: tinyurl.com/latent-X

❄️🔬@science.org Structural basis of BAX pore formation | Science www.science.org/doi/10.1126/...
#CryoEM #apoptosis #mitochondria #BAX

New fabulous #glycotime fresh off the bioRxiv press!⬇️ 🎉 In this brilliant team effort led by Klaudia Sobczak, Jesús Jimenez-Barbero, and June Ereño Orbea 🤩 with many contributions 🌍, we characterised the 3D structure + binding mechanism of sialosides by Siglec-10 🧵 1/3

doi.org/10.1101/2025...

Reposting - please consider applying for a lab head role @wehi-research.bsky.social in Australia. It is a wonderful place to work, in a great country and with lovely colleagues. Clearly I’m biased on all of those counts. Please repost and/or apply!

Make your future Melbourne Lead the next wave of biomedical discovery

🌏 Make your mark in Melbourne! 🌏 We are looking for innovative researchers to join WEHI as Laboratory Heads and help lead the next wave of biomedical discovery.

For more information and to apply 👇

www.wehi.edu.au/careers/make...
WEHI is looking for new lab heads! New and experienced lab heads welcome. Check out the ad, consider applying and share. We’re a collaborative bunch, in Australia, with fabulous technology, great colleagues at a values-driven organisation. @wehi-research.bsky.social

Really interesting work! Congratulations!

Molecular structure and enzymatic mechanism of the human collagen hydroxylysine galactosyltransferase GLT25D1/COLGALT1 - Nature Communications Hydroxylysine galactosylation is essential for collagen maturation. This work reveals the molecular structure of human GLT25D1, its catalytic residues, and a noncatalytic structural domain stabilized ...

Excited to share our new Nature Communications paper describing the molecular structure and the biochemical characterization of human #collagen #galactosyltransferase GLT25D1/COLGALT1 #glycotime www.nature.com/articles/s41...

Bovine H5N1 binds poorly to human-type sialic acid receptors - Nature Nature - Bovine H5N1 binds poorly to human-type sialic acid receptors

After 8 months of peer review, our manuscript was published today @nature.com showing that bovine H5N1 viruses bind poorly to human-type sialic acid receptors. We now know that the virus is only 1 HA substitution away from efficiently binding human receptors.

www.nature.com/articles/s41...

Society for Glycobiology wishes to speak. www.glycobiology.org/index.php?op...

41% of external molecules licensed by large pharma so far in '25 are coming from China said Stifel's Tim Opler on Fri's Biotech Hangout. This is up from 31% in '24. It was 0% in '19. Data from DealForma/CEO Chris D. The # of upfront $ for China biotech licensing deals increased too he said #biosky

Incredibly excited to share Dr Alisa Glukhova has been awarded a prestigious @SnowMedical Fellowship - the only recipient this year!

She'll receive $8M over 8 years to advance her groundbreaking #cancer research.

🔗 www.wehi.edu.au/news/wehi-ca...

Congratulations!

🔬 #Glyco27 Keynote Speaker

Dr. @ethangbaus.bsky.social (Walter and Eliza Hall Institute of Medical Research) studies tryptophan C-mannosylation—a rare glycosylation that impacts protein stability & parasite biology. Catch his talk at Glyco27!

📢 Register: www.glyco27.org/en/begin

Mike spotted this before the rest of us. 🫡

Publications from 2025 are shared more on Bluesky than on X/Twitter.