@gracechoung.bsky.social
Renal pathologist @CedarsSinai #renalpath #kidneydisease opinions are my own
Mineralocorticoid receptor inhibition in parietal epithelial cells prevents focal segmental glomerulosclerosis and crescentic glomerulonephritis.
doi.org/10.1016/j.kint.2025.07.037
#OpenAccess #NephSky #MedSky #CKD #FSGS #chronickidneydisease @parcc-inserm.bsky.social @rwth.bsky.social
IgA Nephropathy #IgAN: An Overview of the Clinical Trials ca. 2025 from @kidneymed.bsky.social @alexgr23.bsky.social @saynanorouzi.bsky.social
#Nephpearls #NephSky
👉 pubmed.ncbi.nlm.nih.gov/41050133/
The kidney slit diaphragm resembles a fishnet
doi.org/10.1016/j.kint.2025.08.028
#OpenAccess #NephSky #MedSky
Diffuse mesangial sclerosis with glomerular sclerosis and interstitial fibrosis (periodic acid–Schiff stain).
#RenalPath: AJKD Atlas of Renal Pathology: Diffuse Mesangial Sclerosis
bit.ly/46AK5kj (FREE)
Kidney txp biopsy for AKI (~6 post txp). Tubular injury associated with granular and ropey trichome positive casts. IHC confirmed myoglobin cast nephropathy. CK found to be very high; thought to be due to statin related myopathy. #renalpath #pathsky #nephsky
04.10.2025 17:17 — 👍 6 🔁 4 💬 0 📌 0
Bx for new onset NS in an older adult. Serologic work up including SPEP/UPEP IFE negative. Bx shows membranous pattern with few double contours. IgG3-k restriction and mottle EM deposits c/w PGNMID with membranous predominant pattern. PLA2R- #renalpath #pathsky #nephsky
05.10.2025 15:30 — 👍 8 🔁 2 💬 1 📌 0
New Podcast: Drs. Levin and Wernerson discuss the findings from their study, "Transcriptomic Patterns in Adult and Pediatric Patients with IgA Nephropathy or IgA Vasculitis with Nephropathy." Listen here: kidney.pub/JPOD0787 #ASNJASN
10.09.2025 15:01 — 👍 3 🔁 3 💬 0 📌 0
New from Dr Barisoni and colleagues in Kidney International
Clinical relevance of computationally derived tubular features and their spatial relationships with the interstitial microenvironment in minimal change disease/focal segmental glomerulosclerosis
pubmed.ncbi.nlm.nih....
It's the weekend-before-abstracts-are-due and we need you to remember two very important things:
1. You've got this
2. Music might help: open.spotify.com/playlist/5EI...
#PathSky #USCAP2026 #YouGotThis
Adequacy and safety of pediatric native kidney biopsy using 16- and 18-gauge needles
30.09.2025 20:03 — 👍 3 🔁 2 💬 0 📌 1
Bartonella is back!
In kidney transplant recipients….from donors!
www.kireports.org/article/S246... in @kireports.bsky.social
Kidney injury and colocalization of complement C3, IgA, and IgG in glomerular immune-complex deposits of patients with IgA nephropathy or IgA vasculitis with nephritis.
#openaccess
Critical role of transcription factor SOX4 in tubular epithelial cell dedifferentiation and fibroblast activation during kidney fibrosis
#openaccess
And it’s live
Iptacopan in C3GN makes it to @thelancet.com
www.thelancet.com/journals/lan...
#NephSky
Figure 1. Timeline describing the transmission of Rickettsia typhi from an organ donor to 2 kidney transplant recipients, Texas, 2024. Day 1 of donor hospitalization is represented as −5, the day of death as −1, and the day of transplantation as 0, after which posttransplant days are listed, ending with the discharge of recipient 1 from the hospital on posttransplant day 20.
Figure 2. Chest radiographs from an organ donor with murine typhus, from a study describing the transmission of Rickettsia typhi from an organ donor to 2 kidney transplant recipients, Texas, 2024. A) Chest radiograph obtained at hospital admission, 5 days after symptom onset, with no specific abnormalities noted. B) Chest radiograph obtained on hospital day 3, revealing extensive alveolar opacities predominantly in the middle and lower lung fields.
Figure 3. Histopathological and immunohistochemical features of formalin-fixed, paraffin-embedded biopsy specimens collected from the right and left kidney allografts procured from a donor who died of murine typhus, from a study describing the transmission of Rickettsia typhi from an organ donor to 2 kidney transplant recipients, Texas, 2024. A) When stained with hematoxylin and eosin, both allografts showed multifocal, interstitial, and predominantly mononuclear peritubular infiltrates, associated with focal endarteritis (thin arrows), features of acute tubular injury, including epithelial attenuation with loss of apical cytoplasm (thin arrowheads), and pigmented casts (large arrow). B) Glomeruli displayed moderate mesangial hypercellularity and tuft adhesions to the Bowman’s capsules (arrows) and intracapillary and mesangial phagocytic foam-cells (arrowheads), That finding is compatible with focal segmental glomerulosclerosis. C) Short chains comprising small, rod-shaped bacteria were revealed in glomerular capillaries by the Warthin–Starry silver impregnation staining technique. Immunoreactive R. typhi antigens were noted within intracellular bacteria in endothelial cells of renal arterioles. D–F) An immunohistochemical stain for typhus-group rickettsiae revealed intact bacteria within endothelial cells of inflamed small vessels and vascular spaces of mesangial capillaries (arrows) and phagocytized bacterial antigens in the cytoplasm of glomerular foam-cells (arrows). Original magnifications ×400 (A, B and E) and ×1,000 (C, D, and F).
Figure 4. Annual case counts of murine typhus in Texas, USA, during 1920–2024. Cases increased from close to zero to ~ 500 in 1930s before spiking to ~2000 in 1940s, then back down close to zero by 1950s, and remained near zero until started creeping back up in 2000s, steadily increasing, now with ~800 cases/year
Donor-derived infections with Rickettsia typhi (agent of murine typhus) in 2 kidney transplant recipients (1 fatal)
Teaching points
- 🐭 typhus transmitted by fleas (& transplant)
- Cases 📈 in Texas
- Death of diffuse 🫁 , 🧠 edema w/o dx=👎 tx
- cfDNA MGS (Karius) can dx
wwwnc.cdc.gov/eid/article/...
A 1-year-old boy with MIRAGE syndrome and nephrotic syndrome, whose kidney histopathology revealed membranous nephropathy-like findings: a case report
MIRAGE syndrome is a rare multisystem disorder caused by gain-on-function SAMD9 variants. Read these Clinical Insights into a 1-yr-old boy w/MIRAGE syndrome & nephrotic syndrome, whose kidney histopathology revealed membranous nephropathy.
link.springer.com/article/10.1...
Join RPS-GlomCon for Renal Pathology Webinar Series
Sunday, September 28, 2025
8:00 AM - 9:00 AM Pacific Time
Ingeborg Bajema, MD, PhD
To register👉https://renalpathsoc.org/event-6113937
#renalpath #pathsky #nephsky #nephrology
@glomcon.org
Heavy Chains, Heavy Consequences: A Case of Concomitant Heavy Chain Amyloidosis and Heavy Chain Deposition Disease. Fibrils and powdery deposits. #renalpath #nephsky #pathsky www.sciencedirect.com/science/arti...
17.09.2025 18:13 — 👍 7 🔁 5 💬 1 📌 0
#RenalPath: Diffuse mesangial sclerosis with typical-appearing dense collagenous material within the mesangium (Masson trichrome stain).
bit.ly/2Hg0Ym1 (FREE)
Our article, “Cumulative Incidence of Mortality Associated with Cardiovascular–Kidney–Metabolic (CKM) Syndrome,” published in JASN @sophieclaudel.bsky.social @asnpublications.bsky.social
has been selected for the “Best of ASN Journals at KidneyWeek 2025. journals.lww.com/jasn/fulltex...
Update
Link changed (will not change again)
So if you liked/pinned the old feed, please do it again!
bsky.app/profile/did:...
#NephSky
Wide variety of morphologies in this case of crystalline light chain proximal tubulopathy: mottle lysosomes, crystals, and fibrils. #renalpath #nephsky #pathsky
06.08.2025 21:32 — 👍 9 🔁 6 💬 0 📌 0
Multiple diagnoses not uncommon in kidney biopsies. This case showed nodular diabetic nephropathy, a mostly chronic ANCA associated GN, and to top it off some interstitial ALECT2 amyloidosis. #renalpath #nephsky #pathsky
11.09.2025 17:21 — 👍 11 🔁 5 💬 2 📌 0
Case report: De novo C3 Glomerulonephritis in a Kidney Transplant Recipient Associated with an Unreported CFH Variant
#openaccess
#C3GN
ICYMI: New content online: Mechanisms of diabetic kidney disease and established and emerging treatments
13.09.2025 12:31 — 👍 4 🔁 2 💬 0 📌 0
Lupus nephritis case with prominent podocyte cytoplasmic vacuolization on LM with myelin figures revealed by EM. Probably HCQ effect but given its prominence genetic etiologies should be excluded (e.g., Fabry, LMX1B). #renalpath #pathsky #nephsky
08.09.2025 23:06 — 👍 12 🔁 6 💬 1 📌 0
Still using the Dallas Criteria to diagnose myocarditis? This article examines the utility of the new Seaport myocarditis criteria at autopsy: www.sciencedirect.com/science/arti...
#cardiosky #pathsky #medsky
Last day for early registration of the 6th International Renal Pathology Conference @ Antigua, Guatemala!
👉 renalpathsoc.org/6thIRPC
Deadline for abstract submission is October 25, 2025
On behalf of the 6thIRPC Organizing Committee,
#renalpath #pathsky #nephsky
The Renal Pathology Society warmly invites nephropathologists and non-pathologists involved in the interpretation of kidney biopsies to participate in a global survey.
More info. below 👇
renalpathsoc.org/RPS-Internat...
@glomcon.org @theisn.org #renalpath #pathsky #nephsky
#pathsky
18.08.2025 05:25 — 👍 5 🔁 1 💬 0 📌 0
