Grace Choung, MD 박영이

Lecithin-cholesterol acyltransferase deficiency with the finding of “zebra bodies”: A diagnostic challenge in the context of suspected Fabry disease Lecithin-cholesterol acyltransferase (LCAT) deficiency is a rare autosomal recessive disorder resulting from mutations in the LCAT gene, which leads t…

Lecithin-cholesterol acyltransferase deficiency with the finding of “zebra bodies”: A diagnostic challenge in the context of suspected Fabry disease
#nephsky #nephrology
www.sciencedirect.com/science/arti...

C3 Glomerulopathy Diagnosis, Current Treatments, and Emerging Therapies ca. 2026 from @kidneymed.bsky.social @jzrenalpath.bsky.social @drraymondhsu.bsky.social @saynanorouzi.bsky.social
#Nephpearls

👉 www.sciencedirect.com/science/arti...

Increased Smoothened signaling promotes kidney fibrosis through inhibiting autophagy in fibroblasts

doi.org/10.1016/j.kint.2026.01.028

#OpenAccess #MedSky #NephSky #renalfibrosis #kidneyfibrosis

Image Quiz! A patient underwent renal transplantation 3 weeks earlier, subsequently developed oliguria, and was found to have circulating donor specific antibodies. Kidney biopsy was performed, and immunofluorescence for C4d is shown. What does the image demonstrate?

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Framework for APOL1-Mediated Kidney Disease Classification Black Americans have increased risk of chronic kidney disease (CKD) compared to individuals without African ancestry. Variants designated G1 and G2 in the apolipoprotein L1 protein encoded by the APOL...

Framework for APOL1-Mediated Kidney Disease Classification - Kidney International Reports www.kireports.org/article/S246...

Allograft biopsy for AKI after belatacept conversion. Yikes! Acute cellular rejection grade III with necrotizing arteritis. #renalpath #pathsky #nephsky

Tubular cell-specific platelet-derived growth factor-B drives formation of fibrogenic niches in kidney fibrosis Kidney fibrosis is the underlying pathological process of chronic kidney disease, a major global medical challenge. In most diseases, fibrosis-initiating injury affects epithelial cells. However, the ...

Tubular cell-specific platelet-derived growth factor-B drives formation of fibrogenic niches in kidney fibrosis - Kidney International www.kidney-international.org/article/S008...

This #ASNKidney360 study evaluated the concordance of pre-biopsy clinical diagnosis with post-biopsy final diagnosis among patients with clinical AKI. Read the article here: kidney.pub/KID1151 Steve Coca

Cumulative Incidence of CKD progression by family history. Numbers less than 11 individuals are suppressed if data are from the USRDS.

Family History of Kidney Failure, APOL-1 Risk Variants, Social Determinants of Health, and Risk of CKD Progression: Findings From the CRIC Study

bit.ly/3NtxtEn

Glomerular basement membrane structural integrity dictates trans-tissue deposition of laminin in the kidney Basement membranes (BMs) are specialized extracellular matrices (ECMs) essential for tissue structure and function. In non-vertebrates, ECM components…

Glomerular basement membrane (GBM) structural integrity dictates trans-tissu... www.sciencedirect.com/science/arti... Really proud of this Cell Reports paper showing that the potentially pathogenic laminin alpha2 in the Alport GBM comes not from glomerular cells, but from the bloodstream.

Histopathological Spectrum of #Acute #Kidney #Injury After #Wasp Sting #Envenomation

https://doi.org/10.1016/j.ekir.2025.11.006

#KIRResearchLetter

Some large KW nodules in this case of diabetic nephropathy. Unfortunately a common occurrence in my biopsy practice. #renalpath #pathsky #nephsky

📖 This weekend don't miss our @kireports.bsky.social #ISNFridaySelection: KIR - Alport Syndrome is a partial tubulointerstitial disease of the kidney www.kireports.org/ar...

The diversity of transplant glomerulitis and its relationship to alloantibody While transplant glomerulitis often signifies antibody-mediated rejection (AMR), the pathophysiology of C4dptc and donor specific antibodies (DSA) negative cases is unclear.

The diversity of transplant glomerulitis and its relationship to alloantibody - Kidney International Reports www.kireports.org/article/S246...

Another chronic glomerulopathy case. EM stage IV of IV resorbed deposits in a pt with PLA2R+ Membranous nephropathy with persistent proteinuria. #renalpath #pathsky #nephsky

Serial Ultrastructural/Proteomic Observations in Light- and Heavy-Chain Deposition Disease Monoclonal gammopathy of renal significance (MGRS) encompasses kidney diseases caused by nephrotoxic monoclonal immunoglobulins produced by small B-cell or plasma cell clones.1 Light- and heavy-chain ...

Serial Ultrastructural/Proteomic Observations in Light- and Heavy-Chain Deposition Disease - Kidney International Reports www.kireports.org/article/S246...

Figure 1 Hematoxylin andeosin–stainedrenal biopsy(original magnification ×40) of the patient showingtubulointerstitial nephritis, characterized by a mononuclear inflammatory infiltrate with clusters ofmacrophages containing round intracytoplasmic structures (highlighted by the black circle). The Grocott-stained specimen (see Supplementary Figure S1) revealed intracytoplasmic round structures consistent with Histoplasma capsulatum yeasts. These histologic features supported the diagnosis of interstitial nephritis by Histoplasma spp. (see Supplementary Figure S1 for the differential diagnosis discussion).

Supplementary Figure S1. Grocott-stained specimen demonstrating intracytoplasmic round structures consistent with Histoplasma capsulatum yeasts (indicated by the red arrow). The differential diagnosis with other fungi (such as Cryptococcus, Candida, Blastomyces, and Paracoccidioides) and other intracellular pathogens (such as Toxoplasma, Leishmania, and Trypanosoma) was made based on the following histopathologic features: small size (2–5 μm), round shape, homogeneous intracellular distribution, silver positivity, absence of kinetoplasts, and negative mucicarmine staining—all of which supported the diagnosis of histoplasmosis.

Acute interstitial nephritis from ....histoplasma

www.kidney-international.org/article/S008...

@kidneyint.bsky.social

#NephSky #RenalPath

Fibrillin-1 is a novel ligand of the epidermal growth factor receptor promoting mesangial cell activation and glomerulosclerosis

doi.org/10.1016/j.kint.2026.01.018

#MedSky #NephSky #glomerulosclerosis

Recent bxs are so important for clinical trial enrolment. Bx in pt with hx of lupus nephritis (IV+V) with worsening proteinuria. Bx for trial enrollment. Chronic changes only, 0 activity, resorbed deposits by EM, min IF staining. #nephsky #renalpath #Pathsky

Bx in older F pt for subnephrotic proteinuria reveals numerous myelin figures in podocytes. Concern for Fabry + other genetic diseases. Subsequently learned the pt was on long term to Plaquenil. Genetics pending, but may all be HCQ tox. #renalpath #pathsky #nephsky

RPS Satellite meeting - Hybrid
Drug Therapies: Footprints on the Kidney
Sunday, March 22nd, 1 - 4 PM CT
In-person: registration available until March 16
Virtual: registration available until March 21
renalpathsoc.org/event-6567896
@uscap.org
#USCAP #renalpath #pathsky #nephsky #nephrology

Silica Nephrolithiasis From Commonly Used Over-the-Counter Vitamins and Supplements: A Case Report | Annals of Internal Medicine: Clinical Cases Silica and calcium carbonate are very rare constituents of renal calculi, historically associated with chronic ingestion of magnesium trisilicate. We present a case of silica and calcium carbonate fir...

supplements are mostly useless, and sometimes dangerous?

stones of silica?

www.acpjournals.org/doi/10.7326/...

what do you make of this @weddellite.bsky.social ? there is a similar @ajkd.bsky.social case report too pubmed.ncbi.nlm.nih.gov/19100669/

Outcomes in children and adults with antiglomerular basement membrane disease Anti-glomerular basement membrane (anti-GBM) disease is a rare, small-vessel vasculitis due to antibodies targeting the glomerular and alveolar capillaries, leading to rapidly progressive glomerulonep...

Outcomes in children and adults with antiglomerular basement membrane disease - Kidney International Reports www.kireports.org/article/S246...

Albumin/Keratin casts obstruct renal tubular and vascular lumens following kidney ischemia. We have recently reported that in ischemic acute kidney injury (AKI), red blood cell (RBC) trapping causes fluid extravasation from the congested capillary circulation and subsequent toxic injury to t...

Albumin/Keratin casts obstruct renal tubular and vascular lumens following kidney ischemia. - Kidney International Reports www.kireports.org/article/S246...

The Oxford Classification Should Remain the Gold Standard for Classification of IgA Nephropathy
journals.lww.com/kidney360/ci...

#renalpath #pathsky #nephsky #nephrology

Recurrence of C3 Glomerulopathy and Immune Complex–Mediated Membranoproliferative Glomerulonephritis After #Kidney #Transplantation: Challenges and Opportunities

https://doi.org/10.1016/j.ekir.2025.11.008

#C3Glomerulopathy #KIRReview

Seronegative Cryoglobulinemic Glomerulonephritis Coexisting With Primary Sjögren’s Syndrome and HBV Infection: A Diagnostic and Therapeutic Challenge Cryoglobulinemic glomerulonephritis (CryoGN) is most often caused by mixed cryoglobulinemia (MC), encompassing both type II and type III forms. CryoGN is commonly associated with HCV infection or prim...

Seronegative Cryoglobulinemic Glomerulonephritis Coexisting With Primary Sjögren’s Syndrome and HBV Infection: A Diagnostic and Therapeutic Challenge
#nephsky #nephrology
www.kidneymedicinejournal.org/article/S259...

Nephrocalcinosis secondary to a parathyroid adenoma

doi.org/10.1016/j.kint.2025.07.030

#NephSky #MedSky #AKI #kidneybiopsy #renalpath #kidneypath

Kidney biopsy day, real-time renal US-guided; adequacy verification, cortex obtained, glomeruli visualized. Come join us to learn more about this in the #KidneyBiopsyAcademy hands-in workshop at @kidneycon.bsky.social 2026

Case Series of Histopathological Findings in Chronic Kidney Disease: Insights From the Kidney Precision Medicine Project The Kidney Precision Medicine Project is obtaining kidney biopsies from people with chronic kidney disease (CKD) and acute kidney injury for comprehensive clinical, histopathological, and molecular ch...

Resurfacing the two latest #KPMP publications for you to read this week 📚

#CJASN #KidneyMedicine #CKD #Protein #Histopathology #Imaging #Research #NewScience

@asnpublications.bsky.social

www.kidneymedicinejournal.org/article/S259...

journals.lww.com/cjasn/abstra...