Joseph Schacherer

Registration is open for the inaugural GRC conference in the Function of Evolving Systems. Aug 9-14, 2026, Waterville Valley. Truly stellar speaker lineup. Student/postdoc fellowships are available! Please come join us! www.grc.org/function-of-... @joybergelson.bsky.social

New lab preprint - Common and rare variant studies for the same trait identify different genes and here Diederik Laman Trip developed a protein network AI enconding to investigate if traits studied by different approaches converge on the same molecular pathways
www.biorxiv.org/content/10.6...

Discovery of additional ancient genome duplications in yeasts Whole-genome duplication (WGD) has had profound macroevolutionary impacts on diverse lineages,1,2 preceding adaptive radiations in vertebrates,3,4,5 t…

Excited to announce our latest publication in reporting evidence for three (3!) new whole genome duplications (WGDs) in yeasts. Scientists have often wondered why WGD is so rare in fungi, it turns out we may just not have been looking hard enough! 🧪 🍄 🧬
www.sciencedirect.com/science/arti...

Directors

Expressions of interest: Director at MPI EvolBio (f/m/d) — We invite expressions of interest from distinguished scientists in evolutionary biology with a bold, long-term research vision that complements our Institute. More information: www.evolbio.mpg.de/3856225/Dire...

From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes - Nature A newly compiled atlas of species-wide structural variants and gene-based and graph pangenomes derived from highly complete assemblies of genomes from 1,086 natural isolates enable integrative genome-...

✨ Latest exciting story of the group in @nature.com. Here, we go beyond SNPs and built a species-wide atlas of genetic variants in yeast. With >1,000 near T2T genomes, we show how large genomic variations affect trait diversity.
www.nature.com/articles/s41...

📣 #EMBOEvoEco returns in 2026 to uncover the mechanistic foundations of ecological and evolutionary change!

Keynote lectures will spotlight the ecology and evolution of symbiosis.

Submit your abstract for the EMBO Workshop: https://s.embl.org/eae26-01-bl!

Abstract submission for #Yeast26 is now open! 🍞🍺

Browse abstract submission topics online and start preparing your abstract today.

Topics include disease models & aging, evolution & population genetics, gene regulation, genomics & systems biology, and more!

Learn more: buff.ly/qotaLne

Flier for conference with list of name of speakers and discussion leaders, Title for conference "Evolutionary Perspectives of Metabolic, Cellular and Genomic Diversity in Fungi", 50th Anniversary Conference Chairs: Bridget Barker & Elaine Bignell. held June 20-21 GRS, June 21-26, GRC. URL https://www.grc.org/cellular-and-molecular-fungal-biology-conference/2026/ and list of speakers names.

2026 is the 50th anniversary of the Cellular and Molecular Fungal Biology GRC. It will be June 21-26, 2026. Consider attending this is a great meeting if you work in the fungal biology field at genetic / genomic / molecular scale. www.grc.org/cellular-and... 🍄🧬🖥️

article from @gillesfischer.bsky.social echoing
www.pnas.org/doi/10.1073/...

Last work of the lab showing that Repeated losses of self-fertility shaped heterozygosity and polyploidy in yeast evolution | PNAS www.pnas.org/doi/10.1073/...

First paper of the year for the HaploTeam, showing how domestication repeatedly reshapes sexual–asexual life cycle trade-offs in yeast, and revealing convergent evolution. Huge kudos to the team, brilliantly led by Jing Hou!
www.pnas.org/doi/10.1073/...

Yeast Genetics Meeting abstract submission and registration sites are open! Abstract submission and registration for the 2026 Yeast Genetics Meeting are now open! Present at this premier meeting for students, postdoctoral scholars, research staff, principal investigators, and...

#Yeast #Genetics Meeting abstract submission and registration sites are open! Abstracts due March 5!

community.alliancegenome.org/t/yeast-gene...

📢 Open PhD position

Phasing polyploid genomes to decipher their phenotypic & adaptive potential

📍 IGBMC - Strasbourg
⏰ Start: Spring
🔍 Profile: MSc in bioinformatics, Python/Bash, R, sequencing data experience a plus.
📩 Application: see below

Haploteam christmas dinner 🎄 to celebrate an intense and demanding year, but one punctuated by great successes. What a fantastic team! Thanks to everyone!

🗞️ New preprint from the lab, led by our postdoc Ana Garoña (not on here) in collab with @andreagiometto.bsky.social: “Experimental evolution of cellular miniaturization reveals a mechanism for cell size evolution”, aka: “honey, we shrank the yeasts!” 🎥
www.biorxiv.org/content/10.6...

Don't wait to book your stay at Fungal 2026!
The reservation site for Asilomar Hotel and Conference Grounds is open until January 13, 2026, but spots are filling up fast #Fungal26
genetics-gsa.org/fungal-2026/...

🧬 Join us at #Yeast26 - Yeast Genetics Meeting!
📍 Asilomar, Pacific Grove, CA
📅 June 13–17, 2026
📝 Abstracts & registration open Jan 5 | Abstracts due March 5
🔗 genetics-gsa.org/yeast-2026/
@genetics-gsa.bsky.social

Population-scale chemical response revealed by a barcoded yeast collection Natural genetic variation shapes how microbial populations adapt to environmental and chemical challenges, but scalable approaches to map genotype-phenotype relationships across diverse genetic backgr...

🚨 New preprint! 🚨@haploteam
We built a barcoded collection of 520 natural S. cerevisiae isolates and screened 600+ natural compounds. Six functional response clusters and 100+ GWAS associations reveal how natural variation shapes chemical sensitivity.
🔗 Read the preprint: doi.org/10.64898/202...

🚨 PhD opportunity in Strasbourg! 🚨
We’re looking for a motivated PhD student to join the @haploteam within the IMCBio program (PhD-2026-17).
🔗 imcbio-phdprogram.unistra.fr

Please spread the word or contact me if you’re interested!

Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast The budding yeast, Saccharomyces cerevisiae, is the workhorse of the brewing industry. Brewers have domesticated a vast array of different strains with traits that complement the beers they wish to br...

Fun new preprint from the lab, headed up by two incredible undergraduate researchers: Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast. www.biorxiv.org/content/10.1...

The discovery and patterns of the underlying long-standing mild-effect mutator alleles in S. cerevisiae populations Most mutations are neutral or deleterious, and mutator alleles that increase the mutation rate of an organism are considered rare and short-lived. Here, we report a genomic signature consistent with t...

New preprint with @pyjiang.bsky.social and @kelleyharris.bsky.social! The discovery and patterns of the underlying long-standing mild-effect mutator alleles in S. cerevisiae populations www.biorxiv.org/content/10.1...

Dynamics of genome evolution in the era of pangenome analysis Long-read sequencing and telomere-to-telomere (T2T) assemblies have enabled the generation of pangenomes that capture genetic diversity beyond single reference genomes. This review highlights how T2T ...

Thrilled to share our latest review! T2T assemblies are reshaping how we study genomic diversity. Pangenomes unlock structural variants, gene presence-absence, and genotype-phenotype relationship, across humans, plants, animals, and fungi.
www.cell.com/cell-genomic...

Congrats!

2026 #Yeast #Genetics Meeting is 13–17 June 2026 in Pacific Grove CA. Conference website has invited speakers, abstract submission topics, preliminary schedule, etc. Bookmark the site as additional updates will be published as they become available. #YEAST26

genetics-gsa.org/yeast-2026/

Congrats!

Yeast genomes show how large genomic variations affect trait diversity Structural variants have a disproportionately large effect on traits such as growth and gene expression.

Research briefings in @nature.com about our latest story on large genomic variations and trait diversity!
www.nature.com/articles/d41...

Had a great visit to @cicbiogune.bsky.social. Impressive science and a welcoming atmosphere!

From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes - Nature A newly compiled atlas of species-wide structural variants and gene-based and graph pangenomes derived from highly complete assemblies of genomes from 1,086 natural isolates enable integrative genome-scale studies of Saccharomyces cerevisiae.

Nature research paper: From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes

go.nature.com/4nVsl9z

Very excited to see the final version of our kingdom-scale fungal genome defense manuscript out in @plosbiology.org !

This work has been a major project of @tbadet.bsky.social during his time in our lab.

We hope to stimulate much more exciting work on fungal TEs.

journals.plos.org/plosbiology/...

From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes Nature - A newly compiled atlas of species-wide structural variants and gene-based and graph pangenomes derived from highly complete assemblies of genomes from 1,086 natural isolates enable...

Incredible new paper from @schacherer.bsky.social et al rdcu.be/eLcTH