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CowperKettle

@artyom-yekat.bsky.social

Freelance translator, now a food delivery cyclist in Yekaterinburg, Russia. Born in 1978.

82 Followers  |  99 Following  |  371 Posts  |  Joined: 22.11.2024  |  1.7962

Latest posts by artyom-yekat.bsky.social on Bluesky

Daniel Kokotajlo on how superintelligent AIs could build a self-replicating robot economy in months
YouTube video by 80,000 Hours Daniel Kokotajlo on how superintelligent AIs could build a self-replicating robot economy in months

www.youtube.com/watch?v=CGMY...

20.10.2025 19:56 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Sam Harris on AI, Identity Politics & Free Speech
YouTube video by Josh Szeps Sam Harris on AI, Identity Politics & Free Speech

www.youtube.com/watch?v=I6Ou...

08.10.2025 22:40 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Plasma Glutathione Concentrations Are Associated with Leukocyte and Neutrophils' Counts in Clozapine-Treated Patients - PubMed Clozapine's potential hematological toxicity, particularly its effect on white blood cell counts, is well documented and routinely monitored in clinical practice. In this study, a significant associat...

A newly-published study I’ve just come across via a tweet by one of the authors:

# Plasma Glutathione Concentrations Are Associated with Leukocyte and Neutrophils’ Counts in Clozapine-Treated Patients (Martinez-Rodriguez et al.,2025) pubmed.ncbi.nlm.nih.gov/41011215/

08.10.2025 07:10 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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🫣

05.03.2025 13:55 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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AGO1 in neural progenitor cells orchestrates brain development and sociability via LIN28A-REELIN axis AGO1, an essential RNA binding protein (RBP) in RNA interference, is associated with autism spectrum disorder (ASD). However, the precise functions of AGO1 in brain development and related disorders r...

AGO1 in neural progenitor cells orchestrates brain development and sociability via LIN28A-REELIN axis #autism #reelin #ASD www.biorxiv.org/content/10.1...

08.10.2025 05:11 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Jane Goodall, Eminent Primatologist Who Chronicled the Lives of Chimps, Dies at 91

Dr. Jane Goodall, 1934-2025

An exceptional scientist, and a singular woman in science

#WomeninScience πŸ’

www.nytimes.com/2025/10/01/o...

01.10.2025 19:23 β€” πŸ‘ 77    πŸ” 17    πŸ’¬ 2    πŸ“Œ 0
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A molecule repairs brain mitochondria and reverses anxiety in rats A study led by EPFL shows that Urolithin A, a natural compound, can abolish high anxiety in rats by repairing mitochondrial function in their brain cells, specifically in the nucleus accumbens. The fi...

Here EPFL press release: actu.epfl.ch/news/a-molec...

07.10.2025 08:43 β€” πŸ‘ 7    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
Redirecting

Very happy to share our new paper in Biological Psychiatry, showing that Urolithin A reverses high anxiety by repairing mitochondrial function in the nucleus accumbens.

Big kudos to first co-authors David Mallet & Doğukan Ülgen, our amazing team, and collaborators!

πŸ”— Paper: doi.org/10.1016/j.bi...

07.10.2025 08:43 β€” πŸ‘ 74    πŸ” 14    πŸ’¬ 4    πŸ“Œ 1
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Mitochondrial control of ciliary gene expression and structure in striatal neurons Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sens...

New lab paper! We reveal a novel mitochondria–cilia interaction in neurons & #mitochondrial control of #ciliary molecular pathways & structure

Kudos to Dogukan Ulgen & Ale Chioino
πŸ™ O Zanoletti, A Quintana, E Sanz
@epfl-brainmind.bsky.social @jphysiol.bsky.social
Read doi.org/10.1113/JP28...

19.02.2025 07:53 β€” πŸ‘ 53    πŸ” 13    πŸ’¬ 2    πŸ“Œ 1

I'm sitting in a stupor and doing nothing. Had psychiatry existed, I would have run to the psychiatrist right away, because in November, a 6th year will start in a dysfunctional state, with no relationships, no proper work. Affect and ruminations.

04.09.2025 03:22 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Beachtown Exile - "Puzata Khata" (Official Music Video)
YouTube video by Beachtown Exile Beachtown Exile - "Puzata Khata" (Official Music Video)

www.youtube.com/watch?v=hxmA...

09.08.2025 12:34 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

During work, I see people holding hands, walking with their kids, and even hugging - and I feel like a steel hook is thrust into my abdomen and is being turned there. I feel like I'm in hell, and this feeling lingers, and ruminations start, and they don't stop.

08.08.2025 16:38 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
The Causes of Autism
YouTube video by UC San Diego Autism Center of Excellence The Causes of Autism

The public wants answers on WHAT ARE THE CAUSES OF #AUTISM. This lecture takes a deep dive on genes, environment and #vaccines and how it works. Video quality is poor in the beginning, but don't skip the first 5 slides or the segment at 20:00-25:00 www.youtube.com/watch?v=Jiy9...

19.03.2025 00:36 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

As we have learned, genes have dose-dependent effects on psychiatric traits. DOSAGE, it turns out, is a key element that helps unravel mechanisms of gene β†’ pathway β†’ cell type β†’ brain region β†’ diagnosis. Here we developed a framework to characterize cellular processes that mediate genetic effects.

16.07.2025 21:23 β€” πŸ‘ 30    πŸ” 8    πŸ’¬ 2    πŸ“Œ 3

The field of neuroscience views the goal of human genetics as "finding genes". This is an outdated view. In whole genome studies of rare variants, finding genes is the easy part. The more interesting and important goal is to map out the causal pathway from genes to brain function to cognitive traits

16.07.2025 14:47 β€” πŸ‘ 95    πŸ” 30    πŸ’¬ 2    πŸ“Œ 3
Anastasia Lykhosherstova - Π‘Ρ–Π³Ρ‚ΠΈ (official audio)
YouTube video by Anastasia Lykhosherstova Anastasia Lykhosherstova - Π‘Ρ–Π³Ρ‚ΠΈ (official audio)

youtu.be/v2pqWb1MC4A?...

15.07.2025 12:52 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Psychiatric medication is in dire need of innovation There can be no either/or in mental health β€” we must rigorously examine pharmaceutical and social solutions

Nice piece by the director of mental health at the Wellcome Trust on the need for innovation in brain-based therapies for psychiatric conditions.

www.ft.com/content/e9ec...

12.07.2025 08:35 β€” πŸ‘ 45    πŸ” 7    πŸ’¬ 1    πŸ“Œ 1
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Complex negative emotions induced by electrical stimulation of the human hypothalamus Stimulation of the ventromedial hypothalamic region in animals has been reported to cause attack behavior labeled as sham-rage without offering information about the internal affective state of the an...

(buried in a reply, but) This is mind-blowing & deserves a post. Scroll to "video" in this article to watch what happens when the human hypothalamus is stimulated: it's a combo of embarrassment/shame and intense body sensations emanating from the heart. WOW.

www.brainstimjrnl.com/article/S193...

13.07.2025 08:49 β€” πŸ‘ 103    πŸ” 24    πŸ’¬ 7    πŸ“Œ 5

Some good news! 😊

13.07.2025 15:29 β€” πŸ‘ 8    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

Every day the world presents you with the wrong battles, designed to waste your energy so you don't fight the right ones.

12.07.2025 23:20 β€” πŸ‘ 270    πŸ” 58    πŸ’¬ 6    πŸ“Œ 5

The oncologist told me that he does not think there might be a metastasis based on my intermittent mild pain in the nose. I wonder if there are good biomarkers of #HPV-associated #squamous cell #cancer of the nasal vestibule.

09.07.2025 09:30 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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РСпост ΠΌΠΎΠ΅ΠΉ Π·Π½Π°ΠΊΠΎΠΌΠΎΠΉ ΠΏΠΎ Π’Π²ΠΈΡ‚Ρ‚Π΅Ρ€Ρƒ
x.com/triki_tiki/s...

30.06.2025 09:22 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

I feel myself dead because I see people in the streets who are holding hands and even kissing. If I were alive, I would have lived with a woman at least for some time over the last 47 years. I cannot go to a psychiatrist because I'm in Russia, we don't have them.

29.06.2025 17:30 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Been taking folinic acid myself and been seeing much more stable energy levels so far, I’m not having a mid afternoon crash like I was. Promising results so far.

16.06.2025 09:11 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
Sometimes You Bomb Iran
YouTube video by Jesse Welles Sometimes You Bomb Iran

www.youtube.com/watch?v=Vcc3...

23.06.2025 01:44 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Lay summary: www.u-tokyo.ac.jp/focus/en/pre...

09.06.2025 08:36 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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Evidence in support of the "Brain from the inside out":

Response to movies is dominated by intrinsic brain dynamics. The dynamic itself is barely alternatered by the task of watching movies.

Human intracranial recordings from 5000 electrodes, now out in eLife.

elifesciences.org/reviewed-pre...

09.06.2025 22:53 β€” πŸ‘ 70    πŸ” 24    πŸ’¬ 2    πŸ“Œ 1
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Noninvasive reduction of neural rigidity alters autistic behaviors in humans - Nature Neuroscience Autism is associated with inflexibility of brain dynamics. Watanabe and Yamasue show that TMS over the right superior parietal lobule while the brain is β€˜stuck’ in a certain state reduces this rigidit...

Autism is associated with inflexibility of brain dynamics. Watanabe and Yamasue show that TMS over the right superior parietal lobule while the brain is β€˜stuck’ in a certain state reduces this rigidity and relieves various autistic traits.

@takamitsuw.bsky.social

www.nature.com/articles/s41...

13.06.2025 18:48 β€” πŸ‘ 50    πŸ” 26    πŸ’¬ 0    πŸ“Œ 3
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At the #ParkRun today. #Yekaterinburg, #Russia #running #jogging #sports

14.06.2025 05:47 β€” πŸ‘ 5    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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White matter disconnection in acquired criminality - Molecular Psychiatry Molecular Psychiatry - White matter disconnection in acquired criminality

Can a brain injury lead someone to commit a crime?

Brain imaging is increasingly introduced as evidence in criminal trials but it remains unclear which structural injuries play a causal role in criminal behavior. @braincircuits.bsky.social @foxmdphd.bsky.social
www.nature.com/articles/s41...

11.06.2025 16:37 β€” πŸ‘ 13    πŸ” 4    πŸ’¬ 2    πŸ“Œ 0

@artyom-yekat is following 20 prominent accounts