Laramie Duncan

Interested in attending Harriet de Wit's Festschrift?*

When: Friday, June 27th, 2025
Where: The University of Chicago
Program: hbpl.uchicago.edu/new-page-2

Talks from @mayoonthebrain.bsky.social @svmahler.bsky.social and many of Harriet's other former trainees!

* no, Harriet is not retiring.

Thanks @ertrunnell.bsky.social

This is exactly what we say: cortical, subcortical, excitatory, and inhibitory are woefully broad terms. We found that prior studies didn’t describe all of the detail that they could have. We provide much greater detail here (though not in the stylized abstract, per journal preference)

We actually looked at developmental atlases too. The results suggest some very interesting distinctions between child and adult disorders… not published yet because we need better powered datasets for some of the analyses

Really intriguingly, these schizophrenia-associated eccentric MSNs were primarily found in the amygdala.

Exactly what Jeremy said! These cells were not known until more marker genes were available. The canonical D1/D2 is not sufficient. They were only discovered (despite being clearly distinct from D1 and D2 MSNs) with single cell / single nucleus approaches.

Thanks, Jeremy and we totally agree. Even more broadly, we observed the eccentric MSN-like neuronal associations for all (well powered) psychiatric disorders examined to date.