Yuri Milaneschi

And now, a more comprehensive #openaccess edited volume 📚 on #Metabolic #Neuropsychiatry is available, capturing the collective work and reflections from the Ernst Strüngmann Forum.
link.springer.com/book/10.1007...

PNIRS 2026

📣 #PNIRS2026: Save the Date‼️

🗓️ June 22–25, 2026
📍 New Orleans, Louisiana 🇺🇸

✨ Whether your PsychoNeuroImmunology research emphasizes the P, N, or I — we look forward to seeing your work and connecting in The Big Easy!

📻 Stay tuned for more info re: call for abstracts. Please spread the word 🙏🏼

Energy Homeostasis in Depression Pathophysiology and Heterogeneity This study examines whether the genetic liability of metabolic, interoceptive, and motivational pathways involved in energy homeostasis regulation is associated with specific symptoms of major depress...

Our study in @JAMAPsych ja.ma/4lVx1eu Using 🧬 we found that disruptions in #energy pathways link to specific #MDD symptoms (⬆️ appetite & sleep). This suggests a #depression profile linked to #metabolic risk, opening doors to targeted treatments. #metabolicpsychiatry

Major depression and atherosclerotic disease: Linking shared genetics to pathways in blood, brain, heart, and atherosclerotic plaques Background The increased risk of atherosclerotic diseases (stroke, coronary artery disease [CAD]) observed in depression may stem from shared pathophysiology. We examined whether: 1) major depression ...

🚨 Preprint Alert 🚨
"Major depression and atherosclerotic disease: linking shared genetics to pathways in blood, brain, heart, and atherosclerotic plaques. " 🧠🫀🩸 The title says it all. Great collaboration with @swvanderlaan.bsky.social . 📄 Read it here: bit.ly/4eTM8T2

In May 2024, I joined an inspiring week at the Ernst Strüngmann Forum on #Metabolic #Neuropsychiatry.

Our first outcome is now in Nature Mental Health:
🧠 A Perspective on energy metabolism in psychiatric disorders
🔗 www.nature.com/articles/s44...

More to come in an upcoming volume—stay tuned!

Nice reminder of our #PNIRS2025 symposium. @eimearfoley.bsky.social, Naoise Mac Giollabhui, @dpmoriarity.bsky.social (in cross-Atlantic telepathic connection) and I will wait for you tomorrow morning!

Looking forward to this!

If you're attending #PNIRS2025 be sure to come to our session (Symposia 4) on Wednesday morning and say hello 👋

@ymilaneschi.bsky.social @dpmoriarity.bsky.social @uob-ieu.bsky.social

Looking forward to connecting with colleagues at #PNIRS2025 in Bordeaux 🇫🇷.
Don't miss our symposium "Dissecting Depression Heterogeneity along Immuno-Metabolic Pathways: Triangulating Evidence from Hierarchical-Phenotyping, Experimental and Genomic Methods"
Time & Outline of the symposium ⬇️

Great discussion. Already on the lookout for the best opportunity to cite Neher 1967!

Acylcarnitines metabolism in depression: association with diagnostic status, depression severity and symptom profile in the NESDA cohort Translational Psychiatry - Acylcarnitines metabolism in depression: association with diagnostic status, depression severity and symptom profile in the NESDA cohort

Our new study in Translational Psychiatry showed that acylcarnitines (involved in mitochondrial #energy production) were linked to the presence+severity of #depression. Bioenergetic pathways may open new avenues in psychiatry #MetabolicPsychiatry check the paper ➡️: rdcu.be/eaWoN

Understanding immuno-metabolic depression | Mental health platform Researchers from ImmunoMIND recently published a review of the research about a form of depression called immuno-metabolic depression.

🔬 What is Immuno-metabolic Depression?

"Recognizing immune-metabolic mechanisms could be a relevant treatment target for part of the depressed population opens the doors to personalised psychiatry.”

Read more: 🔗 https://buff.ly/3WRwYpK

#MentalHealthResearch #DepressionResearch

Countdown on for the annual @pnirs.bsky.social meeting in Bordeaux #PNIRS2025 . Very excited for our member sponsored symposium (June 11) with @eimearfoley.bsky.social and @dpmoriarity.bsky.social on #depression heterogeneity and #immunometabolic mechanisms See you in 🇫🇷

Looking forward! We will try to keep you awake

New collaboration published in @brainbehavimm.bsky.social Analyses leveraging #genetic data highlighted the potential role of #metabolic alterations (e.g., dyslipidemia, dysglycemia) as mechanisms connecting #childhood maltreatment with psychiatric + somatic #multimorbidity. doi.org/10.1016/j.bb...

what a masterpiece!

Titolo fantastico

Article screenshot of a genome-wide association study of major depression published in the journal Cell

1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @cellpress.bsky.social.

www.cell.com/cell/fulltex...

A thread 🧵:

Immuno-metabolic depression: from concept to implementation Major depressive disorder is a common, disabling mental disorder characterized by extensive etiological and phenotypic heterogeneity. This heterogenei…

"Immuno-metabolic #depression: from concept to implementation". Our new collaborative review is out in THE LANCET Regional Health - Europe. We reflected on the current standing of the immuno-metabolic depression concept and its potential value for clinical implementation bit.ly/4iAlVdL #openaccess

Thanks, this gives me the opportunity to acknowledge the amazing editorial work of @eimearfoley.bsky.social, thank you!

It was a pleasure to contribute to @thementalelf.bsky.social. In my piece, I discuss findings from a recent study by Spiller et al. (JAMA Psychiatry) on the heterogeneity of symptom presentation in mental disorder diagnoses.