Andrew Pines

1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social

AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements...

doi.org/10.1038/s415...

Alert!!!!

“An Action Networks Model for Pain”

We propose a new model for chronic pain — and highlight two functionally connected cortical networks that could revolutionize how we treat it.

👉 thread below 🧵

osf.io/preprints/ps...

Coordinate Network Mapping of Focal Brain Volume Differences in ADHD Reveals Common Patterns That Lack Specificity: A Systematic Review Objective Attention-deficit/hyperactivity disorder (ADHD) has been associated with decreased regional brain volume, yet no consistent localization has emerged across studies. This discrepancy has be...

Thrilled our ADHD network mapping work is now out in Annals of the Child Neurology Society, and honored to be featured on the cover!
🔗 Full article: onlinelibrary.wiley.com/doi/full/10....

@childneurosoc.bsky.social @bostonchildrens.bsky.social @simonwarfield.bsky.social @braincircuits.bsky.social

Out now in Brain

A distinct pattern of brain damage intensifies political involvement, regardless of whether you're liberal, conservative, Democrat, or Republican.

With coauthors S.Balters,S. Cohen-Zimerman,G.Zamboni,J.Grafman

academic.oup.com/brain/advanc...

@braincircuits.bsky.social

Mixed Bag #22: Nils Wendel on Learning Psychopharmacology A book, a concept, a person, an article, and a surprise item

Mixed Bag #22: Nils Wendel on Learning Psychopharmacology

Wendel explores the topic using a book, a concept, a person, an article, and a surprise item

www.psychiatrymargins.com/p/mixed-bag-...

MR guided focused ultrasound surgery is an effective and uprising treatment option for Essential tremor. But where is the optimal site to sonicate? Which spots to avoid due to side-effects?

@science.org @braincircuits.bsky.social @netstim.org

– a thread🧵!

www.science.org/doi/10.1126/...

‘Old’ brainstem structure evolved beyond basic motor control The human red nucleus may also help coordinate action, reward and motivated behavior, a new study suggests.

The brainstem’s red nucleus is an evolutionarily old structure that emerged as animals began to use limbs for walking, but its function in humans reaches beyond motor control, a new study suggests.

By @sydneywyatt.bsky.social

#neuroskyence

www.thetransmitter.org/brain-imagin...

Rightfully so!

When modeling volumes of tissue activated in subthalamic DBS for clinical outcomes, does it matter whether we process data in native or template space? Julianna Pijar and Clemens Neudorfer say No in the Brain Stimulation Journal:
doi.org/10.1016/j.br...

🧠💊New preprint differentiating antipsychotic medication vs. illness effects on cortical thickness in people w/ psychosis.

Finding: People receiving placebo show prominent cortical thinning over 1st year of illness, whereas those receiving antipsychotics do not. 1/3

www.medrxiv.org/content/10.1...

We’re hiring a clinical research coordinator to lead a neuroimaging study on brain changes across pregnancy and perinatal depression.

wd1.myworkdaysite.com/en-US/recrui...

Please RT.

It was a great honor to talk with the founding editor of Brain Stimulation, Dr. Harold Sackeim!
Beyond the past, present and future of ECT, we covered the entire field of neuromodulation.

Priceless insights from a key leader in the field!

Tune in here 👇

stimulatingbrains.org/71-harold-sa...

Really interesting thread and super cool work!

We had a truly inspiring and insightful conversation with Dr. Rees Cosgrove, Director of Epilepsy and Functional Neurosurgery at @brighamandwomens.bsky.social & Professor of Neurosurgery @harvardmed.bsky.social

Rediscovering the lost art of brain lesions…!

stimulatingbrains.org/70-rees-cosg...

A postdoc in my lab contacted a fellow scientist to get some advice and was told that, because he's currently working on the topic, he "can't give away all his secrets." I find this extremely lame, and yet I keep encountering it. Science is not a zero-sum game!!

This was a hard one to click the ‘like’ button on. You will be missed!

Probably the most insightful and most important paper on physiomarkers of subthalamic DBS in a long while. Bravo @julianneumann.bsky.social @tsbinns.com and team!!

Out at @natcomms.nature.com:
www.nature.com/articles/s41...

DLPFC Stimulation Suppresses High-Frequency Neural Activity in the Human sgACC Transcranial magnetic stimulation (TMS) to the dorsolateral prefrontal cortex (DLPFC) is hypothesized to relieve symptoms of depression by inhibiting activity in the subgenual anterior cingulate corte...

When we use TMS to treat depression, we think it alters neural activity in a deep brain structure known as the subgenual anterior cingulate (sgACC). But this is hard to test directly, until our preprint with @coreykeller.bsky.social, @neuro-engineer.bsky.social, Nick Trapp, and Aaron Boes (UIowa) 1/

A network correspondence toolbox for quantitative evaluation of novel neuroimaging results - Nature Communications Here, the authors present the Network Correspondence Toolbox, which enables researchers to examine and report spatial correspondence between their neuroimaging results and widely used brain atlases.

It's finally here! Use the Network Correspondence Toolbox to help contextualize your neuroimaging findings 🧠

Cool talk by Aaron Boes on clinical applications and cognitive prognosis from network neuroimaging @bostonchildrens.bsky.social @harvardmed.bsky.social

Started my morning with a super interesting literature search thanks to this prompt!
Were currently analyzing volumetric changes pre and post ECT in schizophrenia - will be really cool to compare seizures that cause psychosis to seizures that improve psychosis. Really admire your work, by the way

We think of white matter as the brain's highways—uniform conduits between cortices. But what if we study development along tracts? Turns out the journey matters as much as the cortical destination! We're thrilled to share “Two Axes of White Matter Development” www.biorxiv.org/content/10.1...
1/n

Proud to share the first of our two-part sequel papers on the #TUS-#DBS project! t.co/yrGRcdpjXn
We recorded local field potentials using #PerceptPc #DBS systems in #Parkinsons patients while applying transcranial ultrasound stimulation (#TUS) — aiming to better understand its effects & mechanisms.

Deep Brain Stimulation response circuits in Obsessive Compulsive Disorder In the field of deep brain stimulation (DBS), two major themes are currently making significant progress. First, the framework of connectomic DBS, in which circuits that are associated with improvemen...

Interested in an update on connectomic and adaptive deep brain stimulation for obsessive compulsive disorder?

Take a look at our summary of this exciting field and how things could be brought together out now in BPS:

www.biologicalpsychiatryjournal.com/article/S000...

A brief 🧵

We could not be more thrilled to welcome this amazing class to Brigham!

🧠 We are #hiring! Postdoc @stanfordmedicine.bsky.social: help us develop closed-loop EEG platforms to improve TMS treatment for depression! Coding and neuroscience / engineering backgrounds required. Join our team! precisionneuro.stanford.edu email: ckeller1@stanford.edu

NIH centralizes peer review to improve efficiency and strengthen integrity The proposed approach is expected to save more than $65 million annually.

Goodbye study sections: www.nih.gov/news-events/...

The Cohen Lab of Translational Neuroimaging is looking to hire a bioinformatics and research data scientist to help accelerate our research and develop new analysis tools! @bostonchildrens.bsky.social @braincircuits.bsky.social

Please consider applying or sharing!
jobs.brassring.com/TGnewUI/Sear...

Mapping Lesions That Cause Psychosis This case-control study analyzes published cases of lesion-induced psychosisTo assess whether lesions that cause secondary psychosis have functional connections to a common brain circuit

JAMA Psychiatry

Mapping Lesions That Cause Psychosis to a Human Brain Circuit and Proposed Stimulation Target

jamanetwork.com/journals/jam...

Awesome work by @barbarahollunder.bsky.social showing how 4 different diseases that can all be modulated at a tiny nuclei (STN) can be differentiated by white matter tracts (to be a little hipster: I’ve been a fan of this since it was a preprint)