Andreas Walther

Let’s get the show on the road. Best way to start the day. #roma

I made it to Cambridge 😀. Looking forward to meeting some ECRs and speaking later today at the Engineering Biology Forum.

Duck 🦆 - chestnuts 🌰 - carrot 🥕- blueberrry 🫐 #chemistswhocook

Saturday 🧑‍🍳. Cod loin, cauliflower coconut purée, cilantro/lime oil and some barberries.. #chemistswhocook #silkysmoothpuree

a black and white photo of a train on the tracks ALT: a black and white photo of a train on the tracks

Looking very much forward to speaking at the Institute for Molecules and Materials in Nijmegen tmrw. Deutsche Bahn is playing all tricks to prevent me from reaching it.

ATP‐Powered Signaling Between Artificial and Living Cells We introduce an ATP-powered artificial cell platform capable of selectively and transiently releasing DNA signals to facilitate communication between artificial and living cells. By engineering these...

Congratulations to Soumya and Charu for making the first ATP-fueled homeostatic cytokine delivery system for communication between artificial and living cells. Now in Angewandte Chemie @angewandtechemie.bsky.social #syntheticcell #noneqsys #DNAnanoscience
onlinelibrary.wiley.com/doi/10.1002/...

Growing functional artificial cytoskeletons in the viscoelastic confinement of DNA synthetic cells - Nature Chemical Engineering Engineering structurally and functionally complex synthetic cells remains a key challenge. Here DNA condensate synthetic cells combine phase separation and DNA nanostructures to reveal how switchable ...

Fresh in @natchemeng.nature.com Growing artificial cytoskeleton in the viscoelastic confinement of DNA Artificial Cells. Brilliant work bey Weixiang! #Syntheticcell #systemschemistry
www.nature.com/articles/s44...

Join us at our EngBio Forum on 10 Nov to hear from Andreas Walther @waltherlab.bsky.social
on creating programmable materials and DNA-based synthetic cells that can process information, adapt,and communicate.
Don't miss it! Sign up 🫱 buytickets.at/engineeringb...

#SyntheticCells #LifeLikeSystems

Computational investigation of the sequence context of arginine/glycine-rich motifs in the human proteome - BMC Genomics Arginine-glycine (RG)-rich motifs are among the most prevalent RNA-binding elements within intrinsically disordered regions (IDRs) of proteins and play crucial roles in RNA metabolism, gene regulation, and the formation of membraneless organelles via liquid phase separation (LLPS). Despite their biological relevance and implication in neurological disorders and cancer, the sequence features and context dependencies that define functional RG motifs remain poorly characterized owing to their disordered nature and sequence variability. In this study, we present a computational framework to dissect the sequence and structural context of RG motifs across the human proteome. By contrasting a functionally defined positive dataset—enriched for RNA-binding and phase-separating proteins—with a negative dataset of RG motif proteins lacking these annotations, we identified distinct compositional and contextual signatures. RG motifs in the functionally defined positive dataset show increased enrichment of phenylalanine, tyrosine, aspartic acid, and asparagine, both within and around the motif, as well as nonrandom spatial relationships with structured RNA-binding domains. Notably, phenylalanine and tyrosine exhibit divergent positional and functional profiles, suggesting distinct mechanistic roles. Our analysis highlights the potential of sequence-based approaches to uncover functional determinants in disordered protein regions and further advances our understanding of the properties of RG motifs, offering a transferable framework for the study of other low-complexity motifs.

🖥️ New Publication Alert
Congratulations to Eric Schumbera, @dormannlab.bsky.social, @waltherlab.bsky.social & @miguelandrade66.bsky.social on their recent publication in BMC Genomics
#RGmotifs #IDRs #LLPS #HumanProteome #ComputationalMotifAnalysis
bmcgenomics.biomedcentral.com/articles/10....

Headshots of speakers Andreas Walther and Claudia Contini next to text that reads "Engineering Biology Forum. Synthetic Cells. Mon 10 Nov. 5pm to 8pm. St Catharine's College, Cambridge".

We're extremely excited to welcome Prof Andreas Walther @waltherlab.bsky.social and Dr Claudia Contini @continiclau.bsky.social for our next Forum

We'll be exploring #SyntheticCells #LifeLikeSystems and #EngineeringBiology from the bottom-up

Don't miss it, register now! 👉 bit.ly/engbio-forum-nov25

Global perspectives on the critical role of diversity, equity, and inclusion in science Diversity, equity, and inclusion (DEI) are fundamental to advancing scientific innovation and addressing complex societal challenges. This Voices piece gathers insights from eight researchers around t...

Really happy to see our most recent Voices article, on the importance of DEI in science, published this week. Includes perspectives from 8 researchers from the USA, UK, China, and Bangladesh www.cell.com/cell-reports...

Soft Robotic Engines with Non‐Reciprocal Motion by Physical Intelligence Movement is vital, and it requires breaking symmetry. This study introduces a hydrogel engine that achieves non-reciprocal motion through kinetic asymmetry in repeated actuation cycles. This approach....

🚨Oli's soft robotic engines are now in #AdvancedMaterials.
A new paradigm for hydrogel actuators - non-reciprocal motion.
Kinetic asymmetry rocks
advanced.onlinelibrary.wiley.com/doi/full/10.... #softrobotics #ercfunded @erc.europa.eu #hydrogel #actuator #noneqsys #lifelike #physicalintelligence

Constructing synthetic nuclear architectures via transcriptional condensates in a DNA protonucleus - Nature Communications Nuclear biomolecular condensates are functional sub-compartments within the cell nucleus. Here, the authors develop a synthetic DNA protonucleus that enables RNA transcription and condensation into di...

🚨Miao's and Weixiang's work on RNA transcription in DNA based condensates as nucleus mimics is now out in @natcomms.nature.com www.nature.com/articles/s41...
#syncell #DNA #condensate #LLPS.
Great work to understand transcription and LLPS in #crowded #viscoelastic environments @sfb1551.bsky.social

What a surprise, we always think that chol-ssDNA stays on the outside of the membrane, but here we learn that this is not correct! Generic across many lipid compositions, for different DNAs. Everything flips! A defect-mediated process. #syncell #DNAnanoscience #RNA A great information highway!

DNA Flipping as Facile Mechanism for Transmembrane Signaling in Synthetic Cells Transmembrane signaling is essential for cellular communication, yet reconstituting such mechanisms in synthetic systems remains challenging. Here, we report a simple and robust DNA-based mechanism fo...

📄🚨 Great work by @Lorena now out in @jacs.acspublications.org "DNA Flipping as Facile Mechanism for Transmembrane Signaling in Synthetic Cells" We show that simple chol-ssDNA does not stay on the outside of GUV membranes but flips inside and can trigger reactions. pubs.acs.org/doi/10.1021/...

A few great days in Vienna at the #schroedinger Institut for a Workshop on #softmatter. Wonderful to meet old Friends from our EU ITN polyamphi from my PHD times. Check out the toilets in the Institute 🫨.

We have a new Dr Zixuan in Tampere !! Congratulations and thank you for the discussion.

We have a new Dr Zixuan in Tampere !! Congratulations and thank you for the discussion.

Heading out to Tampere for a PhD Defense with @arri-priimagi.bsky.social . Looking forward to some good discussions. 🇫🇮🇫🇮🇫🇮

Tomahawk vs chateaubriand. Chateaubriand wins. What a lovely dinner with friends. #chemistswhocook.

a penguin wearing a wizard hat sits at a desk with a computer and the words let chatgpt do it ALT: a penguin wearing a wizard hat sits at a desk with a computer and the words let chatgpt do it

I think #linkedin has entered a new age, where AI and LLM are sending it into self-amplifying cycles of praise and gratitude till explosion of data centers. 😆😆

ATP-Powered Signaling between Synthetic and Living Cells https://www.biorxiv.org/content/10.1101/2025.08.13.670118v1

Become my colleague!!! We are recruiting in a junior faculty level. Junior Professor for Theoretical Chemistry of Macromolecular and Supramolecular Systems
#simulations #theory #noneqsys #assistantprofessor #chemjob
Thank you for sharing this.

berufungsportal.uni-mainz.de/ausschreibun...

A new Tool has arrived in our lab: 2 Photon Lithography by #upnano. Now we can print across all scales. Funded through the @carlzeissstiftung.bsky.social putting it to work for neuroregeneration. #biomaterials #3Dprinting

Fantastic group excursion with the #team. Down the Rhine valley. Great weather, great team, great fun. And huge schnitzel in the evening. Absolutely loved the day.

Adjusting a pool with the very generic pH + and pH - chemicals. Putting my entire academic skillset to work!

@waltherlab.bsky.social taking us on a magical ride about adaptive soft matter. What a treat and fantastic talk at @uniulm.bsky.social!

Small tour in Ulm; looking froward to my @gdch.de lecture today. Most special hotel built in 1300. “The tilted hotel”

#chemistswhocook

Merisier cherries for the duck. - handpicked by myself - because you cannot buy them. So good.

ACDC PwrUp tour. It’s amazing to see the old giants in action.