Nice review article by Szczepanski, Westerhoff and Schechter on this rare entity (pubmed.ncbi.nlm.nih.gov/39743931/)
06.05.2025 03:35 — 👍 0 🔁 0 💬 0 📌 0
The spindled morphology and plexiform architecture can sometimes cause these tumors to be mistaken for (SDH-deficient) GIST. Unlike GIST, these tumors are negative for CD117 and DOG1.
06.05.2025 03:30 — 👍 0 🔁 0 💬 1 📌 0
Special thanks to my U of Michigan colleagues for allowing me to share this case!
13.04.2025 01:40 — 👍 0 🔁 0 💬 0 📌 0
Some nice papers (Fritchie and colleagues/ Chung and colleagues) further elaborating on this entity(ies)….
pubmed.ncbi.nlm.nih.gov/33097826/
pubmed.ncbi.nlm.nih.gov/33300192/
13.04.2025 01:39 — 👍 0 🔁 0 💬 1 📌 0
Fibromyxoid soft tissue tumors/fibroblastic lipoblastomas with a PLAG1 gene fusion often contain foci of myxoid stroma in the background of a more fibrous appearance. In addition to PLAG1 staining, these tumors usually show expression of desmin and CD34.
13.04.2025 01:38 — 👍 0 🔁 0 💬 1 📌 0
I would highly recommend this course for anyone (regardless of level of expertise) looking for a comprehensive/case-based experience with bone and soft tissue. Dr. Fritchie and colleagues at Cleveland Clinic are excellent teachers.
www.clevelandclinicmeded.com/live/courses...
31.03.2025 21:57 — 👍 1 🔁 0 💬 1 📌 0
Nice article on ALK-positive histiocytosis of the breast: pubmed.ncbi.nlm.nih.gov/32826530/
31.03.2025 21:54 — 👍 0 🔁 0 💬 0 📌 0
The liberal use of ALK and histiocytic markers, with follow-up and molecular testing, can help ensure proper identification. These tumors, including the case presented here, often exhibit a KIF5B::ALK gene fusion.
31.03.2025 21:54 — 👍 1 🔁 0 💬 1 📌 0
Interestingly, the cells in this case also showed staining for OCT2, which has historically been associated with other histiocytic-type proliferations, such as Rosai-Dorfman disease, some Langerhans cell histiocytosis, and juvenile xanthogranulomas.
31.03.2025 21:53 — 👍 0 🔁 0 💬 1 📌 0
Unlike IMT, the tumor cells of interest are negative for SMA and positive for PU.1. The cells exhibit more wrinkled and irregular nuclei, which can help suggest histiocytic differentiation.
31.03.2025 21:53 — 👍 0 🔁 0 💬 1 📌 0
Nice article by Dermawan and colleagues on CD34-negative solitary fibrous tumors:
pubmed.ncbi.nlm.nih.gov/34152108/
16.03.2025 18:13 — 👍 0 🔁 0 💬 0 📌 0
Nice article by Dermawan and colleagues on CD34-negative solitary fibrous tumors:
pubmed.ncbi.nlm.nih.gov/34152108/
16.03.2025 18:13 — 👍 0 🔁 0 💬 0 📌 0
Nice article by Sciallis, Chen and Folpe describing this entity. pubmed.ncbi.nlm.nih.gov/22982900/
16.03.2025 18:10 — 👍 0 🔁 0 💬 0 📌 0
Nice article on variable morphologies in desmoid fibromatosis.
pubmed.ncbi.nlm.nih.gov/27124915/
08.02.2025 23:39 — 👍 0 🔁 0 💬 0 📌 0
Of note, familiarity with your lab’s beta catenin stain is important as this stain can have variable sensitivity/specificity for desmoid fibromatosis (this case was negative for nuclear staining). Sequencing for CTNNB1 can be helpful when the staining pattern is suspect.
08.02.2025 23:38 — 👍 0 🔁 0 💬 1 📌 0
While desmoid tumors are often deep seated, these can rarely present as more superficial/subcutaneous lesions. Areas of a more fascicular spindle cell arrangement or “perivascular edema” can help alert the pathologist to pursue additional studies.
08.02.2025 23:37 — 👍 0 🔁 0 💬 1 📌 0
Desmoid tumor with haphazard spindle cell arrangement.
Desmoid tumor with haphazard spindle cell arrangement.
Focal areas of more fascicular like architecture in desmoid tumor.
Focal vessel with perivascular edema.
Desmoid fibromatosis can sometimes exhibit histologic features which overlap with nodular fasciitis, including focal areas of a more haphazard spindle cell arrangement. #BSTpath, #UMichPath, #BSTpathGoBlue
08.02.2025 23:36 — 👍 4 🔁 0 💬 1 📌 0
I like my wife and family, bikes, music, dogs, baking bread and soft tissue tumors. Only the last here though.
Genitourinary pathologist, Cleveland Clinic. Interested in education, publishing (Editor: Int J Surg Pathol), diagnosis of urologic tumors.
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