@shounakgupta.bsky.social
S100
#PathSky 64M, upper chest wall skin lesion. There was some discussion of whether this strikingly “packeted”, strongly S100 protein-positive lesion might be a traumatic neuroma.
20.03.2025 15:26 — 👍 10 🔁 6 💬 1 📌 0
Beta-catenin
#PathSky 37M with a colonic mass. PMH significant only for a thin melanoma of the arm. Long sweeping fascicles of myofibroblasts, thin-walled vessels, perivascular edema, nuclear beta-catenin. “Desmoid- next case.” So why share it here?
21.03.2025 19:23 — 👍 18 🔁 5 💬 2 📌 0
#PathSky 12F with an intra-articular middle finger mass.
14.03.2025 19:05 — 👍 19 🔁 10 💬 1 📌 0
TTF1
#PathSky 84M with lung nodule, signed out as “adenocarcinoma, favor pulmonary origin”. There is supposed to be a bit of TTF1 expression, but it is subtle to say the least.
18.03.2025 18:40 — 👍 15 🔁 8 💬 1 📌 1
#PathSky Older adult with a large, prolapsing esophageal mass. An excellent example of a “giant fibrovascular polyp” of the esophagus. Except that essentially 100% of these turn out to be well-differentiated ( or less often dedifferentiated) liposarcomas.
pubmed.ncbi.nlm.nih.gov/28984298/
Forgot the BRAF photo.
23.01.2025 18:00 — 👍 3 🔁 1 💬 0 📌 0I give up!!!
14.01.2025 01:38 — 👍 0 🔁 0 💬 1 📌 0
Fun EM finding: crystalline proto-renin granules in a renin producing cell of the juxta glomerular apparatus. Important not to confuse this with some sort of pathologic crystal. #renalpath #nephsky #pathsky
07.01.2025 17:08 — 👍 13 🔁 4 💬 0 📌 0
It is nicely positive for SMA, caldesmon and desmin (not shown). But- it is also positive for both MyoD1 and myogenin. NGS found SRF::NCOA2. Leiomyomatous spindle cell RMS. The NCOA2 fused ones usually have a good prognosis. C. Dehner, now at IU, wrote a nice paper pubmed.ncbi.nlm.nih.gov/37422156/
06.01.2025 20:30 — 👍 7 🔁 2 💬 1 📌 0
Just learned about bluesky! For a first post, here is an image of ductal type prostate cancer. Diagnostic criteria can be controversial but common features are columnar cells and papillary structures. Typically considered grade 4. #GUpath
12.12.2024 16:24 — 👍 11 🔁 5 💬 2 📌 0
#slidearchiveseries SMARCB1 deficient renal medullary carcinoma
#gupath #pathsky #pathoutpic
🩸 young pts with sickle cell trait
🔬 cribriform, reticular, nested growth
🎨 PAX8, broad spectrum CKs, CEA, p53
⚠️ OCT3/4 ➕ (50%), pitfall with GCT
🔑 SMARCB1 / INI1 inactivation
PRKAR1A
#PathSky 34M with a jet-black mass next to the seminal vesicle. Melanoma? A very occasional psammoma body was present, and expression of PRKAR1A was completely lost. Malignant melanotic nerve sheath tumor (previously “melanotic schwannoma”) in an unusual location.
04.12.2024 16:57 — 👍 27 🔁 6 💬 1 📌 1
Keratin
SMARCB1
#PathSky Hand mass, 32M. Bland spindle cell tumor with collagen trapping- just an FH, right? Also some less bland epithelioid areas. This is a predominantly spindled epithelioid sarcoma- “modulation” from epithelioid to spindled cells is an under appreciated morphological hallmark. See Comment.
22.11.2024 14:48 — 👍 27 🔁 9 💬 4 📌 2I give up!
26.11.2024 01:43 — 👍 1 🔁 0 💬 0 📌 0
Here is a snapshot of ongoing work to assess HRD status using a clinically validated CGP assay that was presented at AMP
25.11.2024 15:47 — 👍 0 🔁 0 💬 0 📌 0
CD31
ERG
#PathSky. As long as I’m sitting here in Sunday doing a frozen….
73F, arm. Foamy cell angiosarcoma- a very difficult, very rare subtype.
pubmed.ncbi.nlm.nih.gov/20175826/
I am happy to present the results of ongoing work focused on optimizing MSI assessment using smaller targeted NGS panels that was recently presented at AMP
25.11.2024 15:45 — 👍 1 🔁 0 💬 0 📌 0
A stunning image for #FoxOfTheDay shared by @Fox.Family._ on Instagram.
21.11.2024 10:24 — 👍 39150 🔁 1793 💬 240 📌 107
S100
OCT2
#PathSky
Scalp mass, 33M. Just a nice example of soft tissue Rosai-Dorfman disease. I think this low power “pale->pink->blue” look is a good low power clue. In addition to S100 protein, Karen Rech’s group here at Mayo have shown OCT2 to be valuable in this dx. pubmed.ncbi.nlm.nih.gov/33177341/
Nice case!
21.11.2024 02:48 — 👍 1 🔁 0 💬 0 📌 0
