Frederik Haase

"... and may involve research on small molecules/radicals/ions and/or their clusters, materials, or biomolecular systems"
Does this cover all of chemistry or not?

Translational research is digging for gold. Basic research is learning where and what to dig. The more funding is diverted to translation, the more we deplete the research ecosystem, driving the supplies of "gold" - immediately translatable findings and innovations - to unsustainably low levels.

I need an AI to tell me which of the 36 GB of random paper PDF files in my download folder I can delete.

Disorder meets its match Designed protein pockets recognize intrinsically disordered protein regions

Designed protein pockets recognize intrinsically disordered protein regions @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.statnews.com/2025/07/17/n...

The best is when the reviewers are evenly divided between "this is impossible" and "this is trivial"

Sub-stoichiometric 2D covalent organic frameworks from tri- and tetratopic linkers - Nature Communications Using complementary linkers as building blocks in the design of 2D covalent organic frameworks (COFs) limits the formation of compositionally and structurally complex networks. Here, the authors demon...

For example this work resulted from trying to make 2D COFs that are not possible if you assume COFs have to be stoichiometric. The question of feasibility always includes assumptions about what the feasibility rules are.
www.nature.com/articles/s41...

But where do you draw the line? "Energetically unfeasible" "no plausible mechanism"

Why is feasibility even evaluated in grant applications. The best things happen when you try to do impossible things.

Rule #27 when traveling with the train: Check if the water is working before putting soap on your hands.

Looks a bit like disordered hyperuniformity

Coprecipitated Enzyme-Encapsulated Covalent Organic Frameworks for Biocatalysis http://dx.doi.org/10.1021/jacs.5c05496

Announcing a new category of Organic Syntheses article

Maybe it is related to this abomination.

Topological derivative strategy for large-pore three-dimensional covalent organic frameworks https://dx.doi.org/10.26434/chemrxiv-2025-t81dh?rft_dat=source%3Ddrss

What if complexity was already built in — just waiting to be released?
In our latest @science.org, we show how COFs can selectively excise organic macrocycles with precision.
A chemistry that reveals what’s already there. Clip-off Chemistry.
Link: www.science.org/doi/10.1126/...

Beautiful chemistry by the Maspoch group:

Excision of organic macrocycles from covalent organic frameworks Molecules are typically synthesized through stepwise processes involving chemical reactions between simple molecular precursors. Here, we report an advance in the synthesis of new organic molecules ba...

Also this week in @science.org Roberto Sánchez-Naya and collaborators in the Albalad, Yaghi, Imaz & Maspoch groups excise huge 2D rings out of COFs by cleaving well-placed olefinic linkers with ozone

chemsky 🧪

www.science.org/doi/10.1126/...

Very interesting. So no other organic solvents are used?

I would be interested in why it makes a gel. Are both linkers fully dissolved when you add them?

Fantastic news! I am thrilled to be now part from BEAM (beam.uni-halle.de) and to work with brilliant chemist from @unihalle.bsky.social on further developing ABPP probes for plant proteases!
I will be advertising a PhD student position soon!
Watch this space 🧪⚗️

I’m in Europe until the end the end of December! Let me know if you want to hear a talk. Current theme js Metal Organic Frameworks with new stuff—metal tuned immunity (some MOFs prevent antibody formation, some prevent TB) and featuring (not so) subtle political commentary!

Research Associate in Chemistry The Department of Chemistry at the University of Virginia (UVA) invites applications for a Postdoctoral Research Associate to work in the laboratory of Prof. Amrit Venkatesh. The postdoc will engage i...

Please RT. My lab is looking to hire a postdoc to develop applications of solid-state NMR in catalysis. The project will involve significant work on fast MAS & DNP NMR methods.

Apply here: uva.wd1.myworkdayjobs.com/UVAJobs/job/...

#NMRchat #chemsky

‘Perplexanes’ achieve mind-bending molecular topology Zirconium helps to weave entangled nanocarbon cages in high yields

Chemists have woven entangled nanocarbon structures that boast some of the most fiendishly complicated shapes. Dubbed “perplexanes,” they represent an entirely new topological class of molecules. cen.acs.org/synthesis/Pe... #chemsky 🧪

Unlocking Large-Area Free-Standing MOF-Glasses for Molecular Sieving Gas Separation Membranes https://dx.doi.org/10.26434/chemrxiv-2025-5nxmz?rft_dat=source%3Ddrss

Super interesting preprint by Alexander Knebel and coworkers:

(1/4)🚨 Ecstatic to share that Max’s work on #photoswitchable #metallo-supramolecular helicates, with #self-sorting, a #MolecularRatchet and #out-of-equilibrium structures, is now out in @angewandtechemie.bsky.social

👀 doi.org/10.1002/anie...
#ProudPI
#SupramolecularChemistry
#ChemSky
#WomenInSTEM

Super interesting preprint by Alexander Knebel and coworkers:

New preprint: We designed an amphiphilic COF linker to promote phase separation in pores. Turns out proving or disproving phase separation is pretty tricky. We used the solid state eqivalent of NOESY to prove the mixed phase in our system. chemrxiv.org/engage/chemr...

Evidence of Heteroepitaxy and Solid Solutions in Lattice Matched Ternary Covalent Organic Framework Systems Covalent organic frameworks (COFs) are crystalline, porous materials with the possibility for broad applications, but their structural diversity remains constrained by simple net topologies, limiting ...

Alena's and Juliane's paper is now out! By matching linker sizes we could show that disordered mixed ternary phases form, as well as molecularly defined heteroepitaxial interfaces between COFs. @jacs.acspublications.org‬

pubs.acs.org/doi/10.1021/...

A Thorough Characterization of the Tellurocyanate Anion [K@crypt-222][TeCN] was synthesized from KCN, Te, and crypt-222 in acetone. We discuss fundamental properties of [TeCN]−: Single crystal X-ray diffraction, nuclear magnetic resonance (13C, 15N, 125Te...

Excited to kick off this new account with great news: our latest work just appeared in Angewandte Chemie (onlinelibrary.wiley.com/doi/10.1002/...)! Huge thanks to our fantastic collaborators from the groups of Florian Weigend, Xulian Xie, and Xue-Bin Wang!