Single Cell Precision Inc.

Imperative that Tri-council (CDN tax dollars) support scientists in 🇨🇦that have spent decades dedicated 2 🇨🇦, 2 discovery, innovation, 2 mentoring next gen scientists & healthcare professionals. In a country where up to 85% of scientists R not successful at grant capture, 🕐 2 support your scientists🇨🇦.

Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair scRNA-seq has uncovered ontogenically distinct hepatic macrophage populations, but their functions remain unclear. Here, De Ponti et al. identify recruited LAMs and resident LAM-like KCs in multiple l...

🌨️☕👩🏻‍💻 Hepatic cells ! Thanks @federicodeponti.bsky.social for sharing your recent paper www.cell.com/immunity/ful...

Dr. Judy Garber @danafarber.bsky.social discussing outcomes from Olaparib BRCA+/ HER2-ve breast cancer (OlympiA study).
@sabcs.bsky.social #SABCS24

Thanks for sharing.

For Canada, science and the world, AI pioneer Geoffrey Hinton’s Nobel moment signals a pivotal shift For the first time, four Nobel laureates, including Canada’s Geoffrey Hinton, are being honoured for work directly related to artificial intelligence. If anyone still needed a sign that AI has arrived...

For the first time, four #NobelPrize laureates, including #Canada's Dr. Geoffrey Hinton, are being honoured for work directly related to artificial intelligence #AI.🤖🖥️👾
www.theglobeandmail.com/canada/scien...

Implementation and validation of single-cell genomics experiments in neuroscience - Nature Neuroscience Single-cell or single-nucleus RNA-sequencing experiments form a basis for biological insights about cell types and states, but they require orthogonal experiments to confirm the functional relevance o...

Authors present types of orthogonal and functional validation experiments to strengthen preliminary findings obtained using #scRNAseq & #snRNAseq transcriptomics, and details some of the challenges/limitations of these approaches.

www.nature.com/articles/s41...

High content of nuclei-free low-quality cells in reference single-cell atlases: a call for more stringent quality control using nuclear fraction - BMC Genomics The advent of droplet-based single-cell RNA-sequencing (scRNA-seq) has dramatically increased data throughput, enabling the release of a diverse array of tissue cell atlases to the public. However, we...

Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨
We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research!
Read more: bmcgenomics.biomedcentral.com/articles/10....
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Single-cell RNA sequencing illuminates the ontogeny, conservation and diversification of cartilaginous and bony fish lymphocytes - Nature Communications Both cartilaginous and bony fishes have adaptive immune cells, but the evolutionary features of these diverse cell populations remain understudied. Here the authors report single-cell RNA sequencing a...

Well this is interesting. #scRNAseq atlas of immune cells from cartilaginous (white-spotted bamboo shark)& bony (zebrafish&Chinese tongue sole)fishe. Cross-species comparisons show the same cell types across different species exhibit similar transcriptional profiles. 🤯
www.nature.com/articles/s41...

Epidemiology of Cancer AbstractBackground. Cancers are a large and heterogeneous group of malignant tumors that collectively accounted for approximately 600 000 US deaths in 2020

🌤️☕👩🏻‍💻Many #cancers can be caused in part by factors over which ppl & governments have control through choices they make. Top of list: tobacco,alcohol,obesity,diets,lack of physical activity&sun exposure. Contribute 2 your own prevention strategy. #CancerPrevention academic.oup.com/clinchem/art...

"Any sufficiently advanced technology is indistinguishable from magic." (Arthur C. Clarke)

What technology have you used lately that felt like magic to you?

Tumor biomarkers for diagnosis, prognosis and targeted therapy - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Tumor biomarkers for diagnosis, prognosis and targeted therapy

Can biomarker discovery for diagnosis, prognosis and therapy. www.nature.com/articles/s41...

Current challenges and best practices for cell-free long RNA biomarker discovery - Biomarker Research The analysis of biomarkers in biological fluids, also known as liquid biopsies, is seen with great potential to diagnose complex diseases such as cancer with a high sensitivity and minimal invasivenes...

Realistic review highlighting the challenges with biomarker discovery using cfDNA. biomarkerres.biomedcentral.com/articles/10....