Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy - Nature
Decreased brain coenzyme Q10 levels cause encephalopathy and are associated with neurodegeneration; supplementation with 4-HMA or 4-HB restores coenzyme Q10 synthesis in mice and humans with HPDL vari...
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We've used CoQ10 headgroup intermediates to treat mouse models of a mitochondrial disease and improve the neurological symptoms of a patient with this disease.
Grateful for funding from @damonrunyon.org , Pershing Square Foundation, @americancancersoc.bsky.social, NIH!
09.07.2025 17:32 — 👍 9 🔁 5 💬 0 📌 1
Specialist centre for clinical care & research in mitochondrial diseases, The National Hospital for Neurology. Co-leads Profs @RobPitceathly.bsky.social & Mike Hanna
ucl.ac.uk/centre-for-neuromuscular-diseases/patient-services/london-mitochondrial-centre
Research cluster working with @MRCHarwell.bsky.social as part of @MRCMouseNetwork.bsky.social studying mitochondria using #MouseModels
nmgn.mrc.ukri.org
MitoCAMB brings together a team of clinical researchers focused on mitochondrial and neurodegenerative disease translational research.
mitocamb.medschl.cam.ac.uk
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I still like small data but I'm not opposed to big data. We study #metabolism, #genetics, #pediatric inborn errors & cancer.
Assistant Professor at the Van Andel Institute. Alum of: Rutter Lab, UT Austin, Carleton College. Love mitochondria, my girls, running, good food & good friends.
Biomedical researcher studying mitochondrial disorders. PhD from Anu Suomalainen lab, Helsinki. Postdoc at Prokisch lab, Munich.
Multi-institutional collaborative mission to solve the toughest problems in the cerebellum @texaschildrens @bcmhouston
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senior editor at Nature for cellular & mitochondrial metabolism, metabolic physiology, cardiology, vascular biology, clinical science. All views my own.
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Neuroscientist and glial aficionado at NYU Grossman School of Medicine/NYU Langone Health in NYC. Posts in my individual/personal capacity.
My lab is full of awesome people doing amazing stuff - check them out: www.liddelowlab.com
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The MRC Laboratory of Molecular Biology aims to understand biological processes at the molecular level to help tackle human health problems and disease.
Whitehead Institute is a world-renowned, non-profit scientific institution dedicated to improving human health through basic biomedical research.
A lab at the MRC LMB, Cambridge. Interested in dynein, microtubules, cytoskeleton, electron microscopy and much more.
Joint Head of Structural Studies at @mrclmb.bsky.social. Develops & uses #cryoEM to study amyloids in neurodegeneration. #tau, #alphasynuclein, #opensoftware, #RELION. All opinions my own.
HHMI’s Janelia Research Campus in Ashburn, Virginia, is innovating research practices and technologies to solve biology’s deepest mysteries. https://www.janelia.org/
Howard Hughes Medical Institute (HHMI) believes in the power of individuals to advance science through research and science education, making discoveries that benefit humanity.
Scripps Research Professor. HHMI Investigator. Nobel Prize Physiology or Medicine 2021. Opinions my own.
Associate Professor studying cellular metabolism, iron, cancer research. 🏳️🌈Father of two possematolab.org
Group Leader, Cell Biology of Infection Lab @thecrick; Nephrologist @Royal Free Hospital. Own views etc.
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