Riccardo Capecchi

New article to read! Myasthenia gravis following the initiation of statin therapy.

➡️ Statin initiation may be associated with increased risk of new-onset MG during the first 6–12 months.

🔗 doi.org/10.1111/joim.70072

#MyastheniaGravis #MG #statins

The paradox of immune systems conservation between prokaryotes and eukaryotes - Nature Reviews Microbiology The widespread prokaryotic immune systems, in particular restriction–modification, CRISPR–Cas and defensive toxin–antitoxin systems, are absent in eukaryotes, whereas relatively rare ones, such as Arg...

The immune systems paradox

Some widespread prokaryotic immune systems are absent in eukaryotes, whereas relatively rare ones became central to eukaryotic innate immunity

@audeber.bsky.social & E. Koonin hypothesize the answer is #HGT

shareable link: rdcu.be/e2EmD

www.nature.com/articles/s41...

Expansion Microscopy Has Transformed How We See the Cellular World | Quanta Magazine How physically magnifying objects using a key ingredient in diapers has opened an unprecedented view of the microbial world.

Expansion microscopy may be the hi-res hero that many biologists have been craving.

On the balance of knowledge - Nature Reviews Immunology Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems.

"There are several possible reasons for this unsettling state of affairs" www.nature.com/articles/s41...

The actual US government should be stopped. I mean, all of this isn't sufficient for an impeachment?

Human autoantibodies against type I interferons in severe viral disease Type I interferons (IFN-Is) are critical antiviral cytokines that restrict viral replication and limit viral disease. A remarkable recent discovery is…

A very nice review on type I IFN autoantibodies:
www.sciencedirect.com/science/arti...

The IL17REL gene encodes a decoy receptor of IL-17 family cytokines to control gut inflammation - Nature Immunology Qian and colleagues show that IL-17REL functions as a decoy receptor to suppress the effects of IL-17 family cytokines and reduce intestinal inflammation.

The IL17REL gene encodes a decoy receptor of IL-17 family cytokines to control gut inflammation

Qi Li et al. 🧪

www.nature.com/articles/s41...

A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance | PNAS Pancreatic ductal adenocarcinoma (PDAC) has one of the lowest cancer survival rates. Recent studies using RAS inhibitors have opened the door to mo...

Pancreatic cancer is the third deadliest cancer. Treatment often fail due to resistance.

A new study in PNAS led by Mariano Barbacid tackles this with a triple combination therapy that induces robust tumor regression and prevents the onset of tumor resistance in mice.

#SciSky #MedSky #Oncology

I'm so sorry for your loss. And also, for this f*ckin authocratic crazy regime in USA. Remember what happened in Italy with blackshirts

Alex Pretti was a colleague at the VA. We hired him to recruit for our trial. He became an ICU nurse- I lover working with him. He was a good kind person who lived to help and these fuckers executed him.

White. Hot. Rage.

Increased prevalence of #autoantibodies neutralizing IFNλ2/3 in young individuals with #CysticFibrosis. New report from Kevin Groen, Emanuela Bruscia, Marc Emmenegger, Benjamin Hale @benhale.bsky.social and colleagues: rupress.org/jhi/article/...

#Autoimmunity #Infections

Not sure this counts as a timeline cleanse but check out the weird little cars I made

It's AI colonialism

Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity @cellcellpress.bsky.social @thexavierlab.bsky.social @broadinstitute.org
www.cell.com/cell/fulltex...

Exclusive: US gets first $500 million Venezuelan oil deal, holding some proceeds in Qatar The details shared with Semafor mark an initial milestone in the administration’s plan following the ouster of Nicolás Maduro.

The main bank account holding revenue from the Venezuelan oil sales is located in Qatar.

“There is no basis in law for a president to set up an offshore account that he controls so that he can sell assets seized by the American military,” Sen. Elizabeth Warren.

www.semafor.com/article/01/1...

It's me

www.nature.com/articles/s41...

📖 CD19 CAR-T cells for treatment-refractory autoimmune diseases: the phase 1/2 CASTLE basket trial

“CASTLE suggests the feasibility, safety and efficacy of Zorpo-cel in three different autoimmune diseases and paves the way for conducting a pivotal study.”
#SLE #CART

🧬 New in @cellpress.bsky.social 🧵
1/ With @casanovalab.bsky.social , we propose a rethinking of monogenic disorders of immunity:
👉 common variants can matter — a lot.

Chinese Immune Multi-Omics Atlas Human peripheral blood exhibits molecular and cellular heterogeneity across populations, yet the underlying mechanisms remain unclear. We present the Chinese Immune Multi-Omics Atlas (CIMA), character...

www.science.org/doi/10.1126/...

Very interesting paper

DHS Warns Any Action By Americans Will Be Treated As Domestic Terrorism

DHS Warns Any Action By Americans Will Be Treated As Domestic Terrorism https://theonion.com/dhs-warns-any-action-by-americans-will-be-treated-as-domestic-terrorism/

Students’ complicated relationship with AI: ‘Avoiding using it probably put me at a bit of a disadvantage’ As students get stuck into the academic year, there are strong feelings about whether artificial intelligence should play a role in their education

Students get it:

> She also argues that the use of AI can mean that “people aren’t critically thinking” any more. She feels that students who use GenAI consistently “can’t see another viewpoint”.

www.irishtimes.com/life-style/p...

A researcher works at a laboratory bench using instruments and samples during experiments related to developing stem cell‑based immune therapies.

Big breakthrough for living drugs.

UBC researchers have discovered how to grow “helper” immune cells from stem cells—paving the way for more effective and accessible off-the-shelf immune therapies. Learn more: news.ubc.ca/2026/01/stem...

We knows very well what they are: en.wikipedia.org/wiki/Blacksh...

Probably I'll never ask a teaspoon to Bryan Johnson , EVER again

Plot twist: the mysterious new account was generated by an AI, the same AI used to plan the Venezuela blitz.

i feel like i see a lot of "mysterious new account makes big bet on insider information" news stories and not enough people-being-arrested-for-that news stories

YouTube video by BBC News Huntington's disease successfully treated for first time | BBC News

OMG 😭

Huntington's is an inherited disease that's like Alzheimers + Parkinson's all in one. NOW: "once the gene therapy has been delivered into the brain... [it] injects a piece of DNA to reprogram the neuron to become a factory for its own cure."

LIFE SAVING!

www.youtube.com/watch?v=bhEx...

Adenophages are an atypical macrophage population in exocrine glands sustained by ILC2-derived GM-CSF - Nature Immunology Here the authors identify adenophages, a previously unknown macrophage population present in exocrine glands in mice and humans. These cells are dependent on ILC2-derived GM-CSF and support glandular ...

This collab started when I met Fredi at the 2023 #EMDS meeting. Since then it’s been wonderful working with her, @selmatuzlak.bsky.social & Burkhard to explore these GM-CSF dependent #macrophages in #glands. Delighted to see this published in @natimmunol.nature.com 🥳

www.nature.com/articles/s41...

Medici introvabili, disertati i concorsi per il Pronto soccorso Il 17% dei posti resta vacante, ma la percentuale sale al 47% per i reparti di medicina d’urgenza e al 60% per anatomia patologica. In aumento anche chi va via…

#disastrosanità
Medici introvabili, disertati i concorsi per il Pronto soccorso
Il 17% dei posti resta vacante, ma la percentuale sale al 47% per i reparti di medicina d’urgenza e al 60% per anatomia patologica. In aumento anche chi va via dall’Italia: dal 2020 oltre 5 mila professionisti

@blepiro.bsky.social