@sun-in-winter12.bsky.social
https://linktr.ee/christycollins123
These updates are so hopeful!!
29.08.2025 17:06 — 👍 0 🔁 0 💬 0 📌 0La Jolla researchers screened 56 small molecules and found a new class that binds ETF1, a host protein, to disrupt viral ribosomal frameshifting.
These compounds blocked SARS-CoV-2, HIV, and other viruses without harming cells.
www.biorxiv.org/content/10.1...
Thanks for sharing! (I was gonna put it on here too but hadn’t had a chance yet- appreciate your spreading the word! 🙂)
25.08.2025 22:21 — 👍 1 🔁 0 💬 1 📌 0Thx for highlighting @sun-in-winter12.bsky.social
25.08.2025 19:48 — 👍 8 🔁 2 💬 2 📌 0Happy to! Thanks so much for everything you and your colleagues are doing! 🙏
25.08.2025 20:13 — 👍 1 🔁 0 💬 0 📌 0Wow... seems like pretty strong evidence for SARS-CoV-2 persistence in pediatric Long COVID....
25.08.2025 02:06 — 👍 5 🔁 1 💬 0 📌 0
UPDATE: I also created a Substack in case you want to read this post in long-form!
Check it out here: 👇
longcovidbegone.substack.com/p/high-anti-...
Moving forward @polybiorf.bsky.social will support @petterbrodin.bsky.social @casanovalab.bsky.social and colleagues in studying the genetic and hormonal links to these restrained t-cell responses
Grateful for their support in this crisis 🙏
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polybio.org/projects/gen...
We know there is likely more than one root cause of LC, and some people don’t make antibodies at all.
However I think it’s AMAZING that a phenotype of viral persistence has been clearly defined 🎉
We’ve moved past asking whether the virus is still present, to proving WHY
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Screenshot from the paper. Highlighted text says: "All in all, our results suggest that a persistent viral reservoir is likely contributing to Long COVID pathology and ongoing efforts (NCT05823896) to remove such persisting viruses with prolonged antiviral therapies are important and hold clinical promise for delivering a much-needed cure to the community of Long COVID sufferers worldwide."
Of course, the #1 thing to take away from this is that the authors are now hypothesizing about a cure.
That’s right, they wrote the word CURE ✨
Specifically, antivirals (+presumably other strategies) to remove the persistent virus that our t-cells could not.
/15
Basically, we may have evolved this restrained t-cell response for a reason.
The authors say it may be a way for women's bodies to conserve energy for reproduction, and children's bodies for growth.
Now, this trait that was helpful to us in the past is now harming us
14/
Senior author @petterbrodin.bsky.social explains that the answer may lie in our genetics, as well as the fact that the immune system operates differently at different stages of life.
13/
They started to ask the question:
Why does Long Covid more often affect people we'd expect to have STRONGER immune systems?
Why do children and women of child-bearing age disproportionately develop LC, compared to those at high risk of severe acute disease?
12/
Why does this happen?
When the researchers took steps to select the patients who were the sickest, following a mild infection, their patient population came out to a 87% female.
With an average age of 48.
11/
It also tracks with these findings from
UCSF LIINC & @gladstoneinst.bsky.social
Not only did this team find higher anti-spike IgG antibodies, but they also noted a breakdown in coordination between the T- and the B- cells
gladstone.org/news/patient...
10/
The authors note that higher IgG responses to the virus were also found in this study from @putrinolab.bsky.social, @virusesimmunity.bsky.social and many others!
www.nature.com/articles/s41...
9/
Screenshot of my SARS-CoV-2 spike antibody result showing a level of 9,825.00 U/mL
Personally, I totally believe this is what happened to me.
According to the authors, antibody responses normally wane in 6 months, in people who fully recover.
Meanwhile my anti-spike antibodies were just under 10K, 10 months following my acute infection
8/
Our T-cells fail to fully fight off the virus in the initial stage, allowing it to establish reservoirs.
Our B-cells then try to pick up the slack by producing tons of antibodies, but can't seem to fully clear it.
So we end up with viral persistence + high antibodies
7/
For some reason, this process seems to be “restrained” in LC patients.
The team found the higher the level of anti-spike antibodies, the lower the person's rate of CD8+ clonal expansion.
Essentially, the two responses are inversely correlated, when they're supposed to match
6/
Why would this occur?
Normally when the immune system encounters a pathogen, the CD8+ T cells clone themselves to rapidly increase in number.
www.akadeum.com/blog/t-cell-...
5/
So they looked to see what else was wrong.
They found that compared to people who fully recovered, #pwLC tended to have much higher anti-spike antibodies.
In some people, the level of antibodies actually went UP over time, instead of down.
4/
The researchers set out to discover what made these patients different.
They looked for signs of viral persistence, such as spike protein in the blood.
The problem was that different tests gave different results, and didn't always correspond with how the patients felt.
3/
In this study, researchers recruited out of LC clinics in Sweden and Belgium.
They purposely chose patients with the most severe symptoms following a mild infection. The goal was to zero in on the root cause of LC, as opposed to organ damage from severe infection.
2/
Hey everyone, ICYMI I wanted to highlight this groundbreaking #LongCOVID preprint.
Personally, I've found there may be a lot of truth to this idea:
**High anti-spike antibodies that don’t wane 6 months after infection may be a sign of viral persistence**
1/
👇
www.medrxiv.org/content/10.1...
I feel frustrated and ashamed.
Donations are very slow and do not meet our daily needs.😴😰
I call on your humanity to support me and donate to me.🫂🙏
Please follow me, quote, retweet and comment 😔💔
I need you.I love you all Help me by donating🙏😭
gofund.me/421bd4ca
Glutathione and Coq10 help me immensely in the short term. I’m thinking of adding NAD+ injections as well.
Long term, I think we need to clear the persistent virus…
#PwLC reading this… have you benefited from any treatments that would activate NK cells?
Someone mentioned peptides- that’s a really promising area that I’ve been meaning to post about.
Anything else you’ve tried? 11/
And of course, huge, huge thanks to @polybiorf.bsky.social
for supporting this research. Can’t begin put into words how grateful I am, and what it means to actually be feeling hopeful at this point in my LC journey!
This research is just truly incredible.
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bsky.app/profile/poly...
You can watch Dr. Tim Henrich explain their NK cell research, and the rationale for the Anktiva trial, at the 2024 @polybiorf.bsky.social
Fall Symposium: 9/
youtu.be/nzwH556GsuU?...
