Francesco G. Barone, PhD's Avatar

Francesco G. Barone, PhD

@drbaronefg.bsky.social

Postdoc Youle Lab, @NIH @NINDS, USA. Former @WellcomeTrust PhD student @LivUni, UK. Interested in #Neurodegeneration #Mitophagy #Pexophagy #Drosophila. Views my own

29 Followers  |  65 Following  |  3 Posts  |  Joined: 06.02.2025  |  1.3059

Latest posts by drbaronefg.bsky.social on Bluesky


Paper alert! πŸš€very happy to have been involved in this collaboration @livuni-ismib.bsky.social where we developed pexophagy reporters for use in Drosophila research. Great work from @drbaronefg.bsky.social‬

royalsocietypublishing.org/doi/10.1098/rs

07.02.2025 18:27 β€” πŸ‘ 8    πŸ” 6    πŸ’¬ 1    πŸ“Œ 0

Visualize global & tissue-specific #Pexophagy in #Drosophila 🀠
Pexo-QC
Pexo-Keima
SKL signal for translocation to #Peroxisome matrix

@drbaronefg.bsky.social l #OpenBiology 2025
royalsocietypublishing.org/doi/10.1098/...

Read the excellent🧡from 1st auth Dr. Barone πŸ‘‡
bsky.app/profile/drba...

07.02.2025 12:53 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Grateful to the @liverpooluni.bsky.social & @livuni-ismib.bsky.social for providing a great research environment and support throughout this work. Thanks also to my collaborators for their insights and contributions. Supported by @wellcometrust.bsky.social -
@livuniresearch.bsky.social

06.02.2025 19:26 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

🧠 Why does this matter?
Peroxisomes regulate lipid metabolism & ROS detox, and their dysfunction is linked to neurodegeneration & Zellweger spectrum disorders.

Understanding in vivo pexophagy mechanisms provides new insights into organelle homeostasis & disease.

#Autophagy #Pexophagy #Drosophila

06.02.2025 19:26 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
Post image

πŸ“’ New Publication!
Excited to share my latest research in Open Biology! @royalsocietypublishing.org

We developed live Drosophila models to track whole organism and neuronal pexophagy - the selective autophagy of peroxisomes - in vivo.

πŸ“„ Full paper: royalsocietypublishing.org/doi/10.1098/...

πŸ§΅πŸ‘‡

06.02.2025 19:26 β€” πŸ‘ 8    πŸ” 2    πŸ’¬ 1    πŸ“Œ 2
Oxidative Stress Promotes Axonal Atrophy through Alterations in Microtubules and EB1 Function <p>Axons are crucial for transmitting neurochemical signals. As organisms age, the ability of neurons to maintain their axons declines; hence, aged axons are more susceptible to damage or dysfunction....

πŸš€ Hot off the press! Our team findings @livuni-ismib.bsky.social on brain ageing unveil a novel connection between oxidative stress, neuronal microtubules, and the cytoskeletal protein EB1 driving neuronal atrophy. πŸŽ‰ A huge thank you to the fantastic team!
www.aginganddisease.org/EN/10.14336/...

17.01.2025 09:47 β€” πŸ‘ 14    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0

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