What’s next? We’re now exploring how time influences the determination of the point of departure (POD)—a cornerstone of accurate, human-focused risk assessment.

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Key insights:
👉 Time matters: The choice of observation time points directly shapes our ability to detect and characterize chemical effects.
👉 Technology matters: Cell painting and transcriptomic reveal distinct biological spaces, offering complementary insights into chemical responses over time.

A standout finding from Vanille’s work: the critical role of timing and technology in detecting chemical-induced effects in cell-based assays.

📣 I am thrilled to share our latest paper, born from Vanille LEJAL ‘s PhD research together with Olivier Taboureau which leverages public human cell line datasets in a contribution to practically reduce reliance on animal testing and make chemical risk assessment more human-relevant.