George Finney

Tam, Cyster et al. identify GPR34 as a splenic cDC1 receptor that is required for efferocytosis and for the cross-presentation of apoptotic cell–associated antigen to CD8 T cells. rupress.org/jem/article/...

#InnateImmunity #inflammation
@hhmi.org

TCR signaling via NFATc1 constrains IL-15-induced bystander activation of human memory CD8+ T cells Memory CD8+ T cells can undergo TCR-dependent or -independent activation. Here, Lee et al. show that IL-15-induced bystander activation of human memory CD8+ T cells is suppressed by concurrent TCR signaling through NFATc1-AP-1 interactions. Furthermore, they validate a bystander activation gene set induced by IL-15 and decreased upon TCR stimulation.

Online now: TCR signaling via NFATc1 constrains IL-15-induced bystander activation of human memory CD8+ T cells

Tissue-resident memory T cells that express TCF1 or ID3 exhibit stem-like properties and regulate memory heterogeneity and recall @sciimmunology.bsky.social @thedohertyinst.bsky.social
www.science.org/doi/10.1126/...

Cartoon images of three different costumes. A grant proposal due tomorrow. Reviewer number p is greater than 0.1, your imposter syndrome made flesh, the unfinished manuscript, unaccounted for variable

Halloween costumes to scare scientists (by @twisteddoodles.bsky.social) 🧪

Generating functionally stable and antigen-specific Treg cells from effector T cells for cell therapy of inflammatory diseases Antigen-specific and functionally stable Treg cells can be generated in vitro from effector/memory T cells for cell therapy of inflammatory diseases.

Kyoto University scientists converted ordinary T cells into stable regulatory T cells that can suppress autoimmune disease in mice.

This approach may enable personalized, targeted cell therapy for inflammatory diseases.

www.science.org/doi/10.1126/...

Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.

Want to get a tough sample, like lung, looking like this? Read more!

www.biorxiv.org/content/10.1...

Epigenetic regulation of T cell exhaustion in cancer - Nature Reviews Cancer Transcriptional and epigenetic mechanisms governing T cell exhaustion substantially impact immunotherapy effectiveness. In this Review, Kang et al. outline epigenetic regulatory programmes that i...

Review @natrevcancer.nature.com @stjuderesearch.bsky.social
Epigenetic regulation of T cell exhaustion in cancer
www.nature.com/articles/s41...

I'm incredibly honoured to be presenting my research on CD8 TRM in liver fibrosis within the ‘Immune interactions in tissues’ session at @britsocimm.bsky.social Congress 2025!

Added to this, I’m also excited to be selected to share this work as part of the Bright Sparks Postdoc session 🥳

Yang, Farber and colleagues @columbiamed.bsky.social show how lung tissue resident memory T cells optimize protection through IL-10 production which regulates #macrophage-mediated #inflammation in the lungs. rupress.org/jem/article/...

#InnateImmunity #MucosalImmunology

mRNA initiation and termination are spatially coordinated Transcriptional initiation and termination decisions drive messenger RNA (mRNA) isoform diversity but the relationship between them remains poorly understood. By systematically profiling joint usage o...

Thrilled to share our work on transcription initiation and termination being spatially coordinated out today in Science! www.science.org/doi/10.1126/...

More coming on what this means but this was one of those stories that took almost a decade to come together but was well worth the time. Also check out a companion piece on @biorxiv by Patrick Brennan!

Too right! #TeamStroma

Our iconic immune cell badges are back for #BSI25, and you get to choose the next design! 🎨🧫

Vote now and help decide which badge will join the line-up in Liverpool 👇

Cast your vote here🔗: https://bit.ly/46DtHzy

Pre-division TCF1 drop determines long-term CD8 T cell fates @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...

Without an understanding of immune tolerance, organ transplantation will not be possible. Also, their discoveries opened avenues for cancer and auto immune disease therapies.
Congratulations to these year's awardees of the nobel prize in physiology or medicine.
bit.ly/4mC0Gc5

Congratulations to Fred Ramsdell, Mary Brunkow and Shimon Sakaguchi - the 2025 Winners of the Nobel Prize in Physiology or Medicine. #Treg_cells #Foxp3 #Immune_regulation

Review @natrevimmunol.nature.com
Regulators of CD8+ T cell exhaustion
www.nature.com/articles/s41...

Review @natrevgastrohep.nature.com
@ucl.ac.uk @pallettlab.bsky.social @brownromeo.bsky.social
Tissue-resident memory CD8+ T cells: master deciphers of the hepatic environment
www.nature.com/articles/s41...

🎉 Hot off the press! Our new review on liver resident CD8+ T cells is here - exploring the dual nature of these cells either as protective "Jekyll" 😇 or pathogenic "Hyde” 😈

Dive in to see how the liver microenvironment shapes TRM immunity, pathology & therapeutic potential!

Nuclear polarization to the immune synapse facilitates an early transcriptional burst Cytotoxic T lymphocyte target recognition triggers rapid nuclear polarization to the immune synapse and an early transcriptional burst of cytokines.

Now in #Science #Immunology: @griffithslab.bsky.social report that when #CD8 #TCells encounter their targets, #nucleus localizes to the #ImmuneSynapse (IS) & facilitates delivery of newly synthesized cytokines to the IS. They find nuclear polarization represents key step in #CTL -mediated killing!

A liver-infiltrating CD4+ Tfh1 cell response predicts HCV control, hepatitis, and seroconversion during acute infection @jclinical-invest.bsky.social @nationwidekids.bsky.social
www.jci.org/articles/vie...

Exhausted-like effector CD8 T cells mediate immune-stromal interactions at mucosal Chronic Graft-versus-Host Disease onset @biorxivpreprint.bsky.social @nidcr.bsky.social #NCI www.biorxiv.org/content/10.1...

CD103 facilitates the interaction of naive CD8+ T cells with E-cadherin-expressing dendritic cells that in turn provide cytokine-mediated cues to promote their differentiation into memory-phenotype effector T cells @cp-immunity.bsky.social
www.cell.com/immunity/ful...

T-cell immunity against influenza virus does not require Th1 or Th17 master regulator transcription factors www.mucosalimmunology.org/article/S193...

In @jem.org, Arase, Murakami, Takeda et al. identify RUNX2 and BHLHE40 as key factors driving tissue-resident memory T cells (TRM) characteristic of #Crohns disease. Blocking these transcription factors mitigated the cytotoxic TRM phenotype in human disease samples. rupress.org/jem/article/...

CXCR6 promotes dermal CD8+ T cell survival and transition to long-term tissue residence @jimmunol.bsky.social @thelundlab.bsky.social
academic.oup.com/jimmunol/adv...

A Human Single-cell Atlas Identifies OLR1+ Scar-associated Macrophages as a Therapeutic Target for Chronic Liver Disease Chronic liver disease (CLD) is a major global healthcare problem. Irrespective of cause, chronic damage to the liver results in fibrosis, which is associated with adverse clinical outcomes. Immune cel...

Fantastic to see this out 👏

ScRNAseq data from 77 patients as an atlas for all to use. Used to identify a new subpopulation of pro-inflammatory scar-associated macrophages which promote fibrosis from our friends in the Ramachandran lab. 🧪 #liversky #immunosky

www.biorxiv.org/content/10.1...

Single-cell atlas of human liver and blood immune cells across fatty liver disease stages reveals distinct signatures linked to liver dysfunction and fibrogenesis @natimmunol.nature.com
www.nature.com/articles/s41...

The diversity of CD8+ T cell dysfunction in cancer and viral infection - Nature Reviews Immunology Beyond exhaustion, CD8+ T cells can adopt various dysfunctional states, including tolerant, anergic, senescent, ignorant and dying states, that compromise their ability to eradicate viruses or tumours...

Absolutely brilliant review #Freshoffthepress

www.nature.com/articles/s41...

#CD8Tcelldysfunction