Aditya Singh Rajput

Can pressure gradients persist over long timescales in animal cells? We induced intracellular pressure gradients and examined the resulting flows in single cells. We reveal surprisingly long lasting pressure gradients.

More here: elifesciences.org/reviewed-pre...

Rapid Divergence of Visual Systems and Signaling Traits to Contrasting Light Regimes During Early Speciation of African Crater Lake Cichlid Fish Abstract. Sensory adaptation is widely hypothesized to drive ecological speciation, yet empirical evidence from natural populations undergoing early stage

Very proud of this extremely collaborative piece: academic.oup.com/mbe/article/...
Here, we show that divergence in visual systems - in response to differences in the light environment - leads to rapid divergence in sexually selected colour traits. Work brilliantly led by Madeleine Carruthers. 🐟👀🎨

📣Our project, “Mechanometabolic Control of Vertebrate Limb Elongation,” has been funded by Wellcome!
Over the next 8 years, we’ll collaborate with @manningresearch.bsky.social and Nathalie Agar’s group to understand the mechanics of ECM-rich mesenchymal tissues! Funded positions available!🎉

The final version of our review on biological filaments is out in Philtrans A (w/@jcammann.bsky.social Hannah Laeverenz-Schlogelhofer & Marco Mazza) - we have 417 references!
Enjoy :)

doi.org/10.1098/rsta...
(see also other articles in this special issue on biological fluid dynamics) #biophysics

@natalieadye.bsky.social @mbisg.bsky.social opened the session discussing the importance of 3D imaging to understand how tissues grow in the correct direction – Full 3D imaging of Drosophila wing disc revealed new dynamics, pouches and folds in the apical surface. #MBIMPG2025

Out now in Seminars in Cell & Dev Biol!

doi.org/10.1016/j.se...

With thanks to co-authors @callumbucklow.bsky.social and @bertaverd.bsky.social

EvoChromo: Evolutionary approaches to research in chromatin Chromatin is the complex of DNA, RNA and protein that is found making up the chromosomes in eukaryotic cells. Chromatin is essential for proper genome function and is involved in chromosome segregati…

Please re-post:

Interested in chromatin and its evolution? Good news! There's still time to join us in beautiful Catalonia (9-12 Dec) to discuss eukaryotic, bacterial, archaeal, and viral chromatin and how it all hangs together meetings.embo.org/event/24-evo...

Abstract deadline: 30 September

Flies evolved a shock-absorber tissue used during embryonic development The role of tissue that forms between the head and trunk of a fly embryo has been unclear. It turns out that it absorbs forces when nearby cells move and divide.

The papers have been improved by reviewers @amartinezarias.bsky.social, @thibautbrunet.bsky.social & Cassandra Extavour. Thibaut synthesized the work beautifully in the #News_and_Views. None of that can happen without The Editor: @endofthepier.bsky.social (11/12)

www.nature.com/articles/d41...

Super excited that our group will be supported by an ERC Starting Grant!

In project "InfoFate" we will study how cells use information in dynamical, neighborhood & mechanical signals to make decisions.

We'll have PhD and Postdoc positions available, please get in touch if interested!

Are you a biologist with a research interest in embryogenesis or synthetic biology?
Join our upcoming residential scientific meeting in Brighton on 20-21 October on the topic of generative biology: royalsociety.org/science-even...

🧵Why do early embryonic cell cycles speed up with temperature almost like simple chemical reactions, but not quite? 🌡️

Across frogs, fish, worms, and flies we found a shared scaling law, and uncovered why deviations from Arrhenius behavior emerge.

👉 doi.org/10.1038/s41467-025-62918-0

Congratulations, Lendert! Fantastic stuff.

How did life get multicellular? Five simple organisms could have the answer Nature - Single-celled species that often stick together in colonies have researchers rethinking the origin of animals.

For some three billion years, unicellular organisms ruled Earth. Then, around one billion years ago, a new chapter of life began

go.nature.com/4lPmznS

Lee, L. W., Lee, G. H., Su, I. H., Lu, C. H., Lin, K. H., Wen, F. L., & Tang, M. J. (2025). Mechanobiological mechanism of cyclic stretch-induced cell columnarization. Cell reports, 44(5), 115662. #EpithelialMechanics
buff.ly/j67xoTn

Spatiotemporal WNT and BMP gradients orchestrate regional enteroendocrine cell diversity along the Drosophila midgut https://www.biorxiv.org/content/10.1101/2025.08.27.672561v1

We are excited to announce our new #partnership with the Mechanobiology Institute (MBI) in Singapore! 🇸🇬

This collaboration will combine MBI’s expertise on molecular, cell, and tissue mechanobiology with our research on spatiotemporal organization of living matter to understand how organisms form 🔬

🤔 How do protrusion & polarity interactions govern the collision behavior of migrating cells?

Check out our paper, just out in @prxlife.bsky.social
👉 journals.aps.org/prxlife/abst...

Great work by Tom Brandstätter, in collab. w/ Chase Broedersz & Joachim Rädler @cens-lmu.bsky.social

📣 Now out in @physreve.bsky.social‬ as editors' suggestion: our theory on the role of different myosin II isoforms during cell migration. For standard parameters, A and B segregate to the front and the back, respectively. Yet for other parameter values, also oscillations are possible.

Investigating morphogen and patterning dynamics with optogenetic control of morphogen production Morphogen gradients provide the patterning cues that instruct cell fate decisions during development. Here, we establish an optogenetic system for the…

Our latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh

🧵

www.sciencedirect.com/science/arti...

A cell's internal spin direction results from myosin chirality – insight into how left-right symmetry is broken in certain tissues & organs

📷 Takaki Yamamoto et al @riken-bdr.bsky.social
in @elife.bsky.social

➡️ bpod.org.uk/archive/2025... with Lux Fatimathas

🧬🔬🧪 🎉 Our team at @czbiohub is thrilled to share TWO companion papers out today in @NatureMethods!
📦 Ultrack — robust, scalable nD cell tracking
🌐 inTRACKtive — a beautiful, open-source web viewer for lineage exploration
Let’s dive in! 👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Very happy to see it out, another fun collaboration with the Sixt group at @istaresearch.bsky.social ! See Mehmet's thread for a summary of how different immune cells can "surf" on each other's self-generated gradients to drive efficient co-migration!

Brand-new conference on collective behaviour! Join us to foster a community to study how interactions among the constituents trigger fascinating collective phenomena: biofilms, fish schools, tissue self-organisation, bird swarms & many more!

Thanks to amazing speakers for helping us realise this!

illustration of a person peering through DNA helices at animal silhouettes

Kin selection has sparked debate for decades.

Now, a landmark study offers a generalised version of Hamilton’s rule, capturing the messy, nonlinear reality of evolution and cooperation.

Explained in our latest Insight Article: buff.ly/EKfPBhH
#EvoBio #Evolution

A switch to non-proliferative growth sustains Drosophila wing development during the early pupal stage Using precise tissue volume quantification, El Marzkioui, Gaugué, et al. show that wing primordia continue to grow during the early pupal stage, a phase of increased cell volume driven by insulin/IGF ...

Our new paper is out in @currentbiology.bsky.social! Using 3D reconstructions and volume measurements in Drosophila wing primordia, we show that growth can be uncoupled from cell proliferation and uncover a new time window for growth arrest.
With @leopoldlab.bsky.social
www.cell.com/current-biol...

The goal of a PhD is not to learn some facts or read a few papers or learn a bunch of techniques. The goal of a PhD is to learn independence, problem solving, how to finish things you start, resilience, & gain the ability to adapt & think creatively. Learning these things is hard.

Ice, Rock, and Beauty

'Ice, Rock, and Beauty', by David Brodie, provides readers with a comprehensive survey of our cosmic neighborhood, the Solar System, and allows readers to appreciate our growing place in the wider environment, on Earth and beyond. bit.ly/4lswGip #BookSky #SolarSystem

Contact Dynamics of Cytoadhering Plasmodium falciparum-Infected Erythrocytes in Flow The virulence of the human malaria parasite Plasmodium falciparum is linked to the altered mechanical and adhesive properties of infected erythrocytes, which adhere to the microvascular endothelium to...

Now out in ACS Infectious Diseases @pubs.acs.org: joint work from the Lanzer, Tanaka, Schwarz and Cavalcanti-Adam labs within #SFB1129 on the adhesion footprint of malaria-infected infected red blood cells. Read the open access paper here: pubs.acs.org/doi/10.1021/...

3D epithelial cell topology tunes signalling range to promote precise patterning https://www.biorxiv.org/content/10.1101/2025.08.08.668674v1