@jamesdmanton.bsky.social
Applied physicist & microscopist/microscopologist
We present multi-immersion Oblique Plane microscope (miOPM), a light-sheet platform that can be adapted to a wide range of applications, from sensitive live cell imaging to imaging organs and cleared tissues.
www.biorxiv.org/content/10.1...
Exciting news for #drosophila #connectomics and #neuroscience enthusiasts: the Drosophila male central nervous system connectome is now live for exploration. Find out more at the landing page hosted by our Janelia FlyEM collaborators www.janelia.org/project-team....
05.10.2025 15:40 — 👍 127 🔁 64 💬 2 📌 8
Excellent opportunity for an enthusiastic #postdoc to join Kate McDole in @cellbiol-mrclmb.bsky.social, using interdisciplinary approaches to investigate tissue formation during early organogenesis in mouse embryos.
More info: www.nature.com/naturecareer...
Closes 20 OCT
#ScienceJobs #PostdocJobs
LMB PhD studentship available in the Baum lab to use informatics to infer cell structure from genomic data in collaboration with the brilliant Tom Williams. If you write to me and I don’t reply - try again - the spam filter is hungry…
02.10.2025 09:04 — 👍 17 🔁 19 💬 1 📌 2
📣📣We're seeking a postdoc to join us at the @mrclmb.bsky.social to investigate neuroimmune interactomes in tumour & viral immunity.
If you find fascinating & want to learn about #neuroscience & #immunology, tracing neurons, molecular biology & #flowcytometry, apply!
🧠🫁👀🩸🔬
mrc.tal.net/vx/mobile-0/...
Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging
www.biozentrum.unibas.ch/open-positio...
#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging
BioImage analysis friends - King's are recruiting for a full-time, permanent facility position! Come and work with fun microscopes and fun people (and me!) - please share! www.kcl.ac.uk/jobs/126345-...
29.09.2025 09:48 — 👍 60 🔁 80 💬 0 📌 0Latest imaging data from our completely re-designed ExA-SPIM system.
Expansion-assisted imaging (3X expansion, 0.3 NA) enables brain-wide imaging with high-contrast and <400 nm effective resolution.
We were also concerned by that, so I thought we could use a cleared tissue lens and use Kramers–Kronig clearing to tune n to be just right.
Yeah, that doesn't seem to work... The gel shrinks quite a lot. I have a few more tricks to try before we give up, but you might also want to play with it.
If you want to go further, then @adamkglaser.bsky.social is the person to talk to!
bsky.app/profile/adam...
@miguelcmestre.bsky.social is at the GEF25 with a poster on how we use them if you want a chat. He might also be able to give people a sneak-peek into the high-expansion-factor sectionable gel chemistries he's now working on to increase the effective working distance further still.
28.09.2025 15:43 — 👍 2 🔁 0 💬 1 📌 0We're big fans of the Zeiss 40x/1.0 with 2.5 mm WD (www.micro-shop.zeiss.com/en/us/shop/o...) and the Nikon 60x/1.0 with 2.8 mm WD (www.microscope.healthcare.nikon.com/en_EU/produc...). Both work great on our inverted microscopes when using an FEP coverslip (www.biorxiv.org/content/10.1...).
28.09.2025 15:43 — 👍 8 🔁 0 💬 1 📌 0Live stream of the talks at #GEF25! Experience the best of ExM first hand! Tomorrow 9 am it is me btw. Monday 9 am Ed Boyden himself!
27.09.2025 14:38 — 👍 7 🔁 1 💬 1 📌 0We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM.
Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩
#RNA #cryoEM
The Molecular Brain Mapping group at the MRC-LMB is hiring! 🌈🧠
I'm looking for people who are excited about revealing the many molecular layers of the "hidden connectome" with expansion microscopy, in a highly intersectional environment exploring ideas in meta-science.
mrc.tal.net/vx/mobile-0/...
The Molecular Brain Mapping group at the MRC-LMB is hiring! 🌈🧠
I'm looking for people who are excited about developing multimodal analysis and visualization tools to capture the "hidden connectome," in a highly intersectional environment exploring ideas in meta-science.
mrc.tal.net/vx/mobile-0/...
Join the LMB's PhD programme! Applications now open for October 2026 Deadline 2nd December 2025
Calling all prospective PhD students! Why not consider the LMB for your PhD?
Applications are now open!
www2.mrc-lmb.cam.ac.uk/students/int...
General deadline: 2nd DEC
US Gates Scholarship deadline: 15th OCT
@science.org🧬🔬Functional maps of a #genomic locus reveal confinement of an enhancer by its target #gene | Science www.science.org/doi/10.1126/...
22.09.2025 19:43 — 👍 39 🔁 9 💬 0 📌 0SCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N
17.09.2025 17:20 — 👍 60 🔁 26 💬 4 📌 4
Our new preprint is up! This is the main postdoc work of @wiesner-t.bsky.social focusing on exocytosis along the axon shaft and its regulation by the sub membrane actin-spectrin scaffold: www.biorxiv.org/content/10.1...
Read the thread below for a summary of our findings 🧵1/11
After seeing
@miguelcmestre.bsky.social @lancasterlab.bsky.social @jamesdmanton.bsky.social
's paper this week on deep and accessible ExM imaging with cerebral organoids, I think it's a good time to repost this Starter Pack of Expansion Microscopy people!
go.bsky.app/Qxks9WD
🚨Publication alert🚨
My first, first-author paper is now out in @natphoton.nature.com! Our paper describes an iterative spectral unmixing algorithm and eight-channel camera-based hardware we developed enabling unmixing of low SNR live-cell data at video rates. www.nature.com/articles/s41...
The final version of our multispectral microscopy manuscript is now online at Nature Photonics: www.nature.com/articles/s41...
The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.
Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...
15.09.2025 18:03 — 👍 160 🔁 67 💬 8 📌 7The cat is officially out of the bag!
The LMB is home to a unique community of outstanding connectomics scientists — I'm so excited about adding my own molecular and expansion microscopy expertise to the mix!
This is going to be the most exciting journey of my scientific career — more soon! 🌈🧠
We present a simple method to easily increase the imageable depth of an expansion microscopy gel on a typical inverted microscope ten-fold, using some carefully placed FEP film and a water dipping objective lens:
15.09.2025 08:42 — 👍 65 🔁 30 💬 2 📌 0
We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry ( www.jobs.ac.uk/job/DNW809/r... ) at the MRC Laboratory of Molecular Biology (LMB).
14.07.2025 12:09 — 👍 27 🔁 33 💬 1 📌 4
I'll soon be recruiting a postdoc fellow to join us @mrclmb.bsky.social to continue developing our programme to understand neuroimmune modulation🧠🔬🧬🩸🫁
If you're interested in joining us check also @erc.europa.eu MSCA actions, @wellcometrust.bsky.social & www2.mrc-lmb.cam.ac.uk/recruitment/...
DM'me
The only good use I've managed to find for generative AI is rewriting my paper abstracts in quatrain.
The Mind's Decay, A Fading Light
Niamh Burke (centre) receives the RMS Early Career Award from Lisa Maria Needham (left) and Michelle Peckham (right)
Massive congratulations to Niamh Burke @niamh-deburca.bsky.social on winning the 2025 @rmsearlycareer.bsky.social Early Career Award, with her talk on the enderscope community project, co-developing accessible imaging tools with the public. 😀🙌🔬👍
@bioimaginguk.bsky.social
