James Manton

A great opportunity to come to Glasgow for an interdisciplinary PhD, benefitting from enhanced support and stipend, and a diverse cohort of students alongside you for an inclusive, team experience for your PhD! Please share widely, and spread the word with your undergraduate students.

4Pi-SIMFLUX: 4Pi single-molecule localization microscopy with structured illumination - Nature Methods 4Pi-SIMFLUX is a single-molecule localization microscopy approach that achieves a near-isotropic resolution below 10 nm in whole mammalian cells.

We are happy to share our latest work, 4Pi-SIMFLUX, which combines structured illumination with interferometric detection to achieve near-isotropic 3D localization precision of 2–3 nm and resolve sub-10 nm structural features across whole mammalian cells.
www.nature.com/articles/s41...
rdcu.be/eQVxt

StayRose: A photostable StayGold derivative redshifted by genetic code expansion Photobleaching of fluorescent proteins often limits the acquisition of high-quality images in microscopy. StayGold, a novel dimeric GFP recently monomerized through sequence engineering, addresses thi...

Our new paper is published in the Journal of Chemical Biology! 🏮 We share StayRose, a red version of StayGold 🏮 StayRose has an unnatural amino acid-based chromophore, and has the same immense photobleach-resistance as StayGold 💡

Join the LMB's PhD programme! Applications now open for October 2026 Deadline 2nd December 2025

Want to join the LMB as a PhD student in October 2026?
You’ve got two weeks left to apply!
Visit our website for more details: www2.mrc-lmb.cam.ac.uk/students/int...
Applications close on 2nd December 2025.

An Asgard archaeon with internal membrane compartments

Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!

www.biorxiv.org/content/10.1...

Lots of exciting PhD projects on offer at the LMB, including in our group 😊

We are delighted to announce the Strathclyde Optical Microscopy Course 2026 (SOMC26), taking place in Glasgow from 21st July – 30th July 2026!

Please find more details at shorturl.at/xmUiZ and apply at shorturl.at/MxTlI. Deadline 16 January 2026.

Thanks! Great that it worked for you!

We've now discovered some neat cell culture dishes that feature a 50 micron thick film of a proprietary polymer with refractive index even closer to water than FEP. They work just as well as our homemade FEP assembly and are available in multiwell plate format too!

www.sarstedt.com/en/products/...

A new, nerdy paper. We figured out (some) of the rules underlying cell-permeability of probes and designed ligands that light up, grab, and move proteins around. Awesome @hhmijanelia.bsky.social x @uwmadison.bsky.social x @stjuderesearch.bsky.social collaboration! www.pnas.org/doi/10.1073/...

Chris Russo and Anastasiia Gusach have developed a new method to prepare #cryoEM samples that avoids protein damage during freezing

Read more: www2.mrc-lmb.cam.ac.uk/a-new-method...

#LMBResearch

Structure of riboflavine

Periodic reminder that the fluorescent compound in mammalian cell culture media, such as DMEM, is riboflavin (not phenol red)

📣 Two week left to apply! 👇

Apply in the link below or, if you have specific questions, reach out!

We present multi-immersion Oblique Plane microscope (miOPM), a light-sheet platform that can be adapted to a wide range of applications, from sensitive live cell imaging to imaging organs and cleared tissues.
www.biorxiv.org/content/10.1...

Male CNS Connectome A team of researchers has unveiled the complete connectome of a male fruit fly central nervous system —a seamless map of all the neurons in the brain and nerve cord of a single male fruit fly and the ...

Exciting news for #drosophila #connectomics and #neuroscience enthusiasts: the Drosophila male central nervous system connectome is now live for exploration. Find out more at the landing page hosted by our Janelia FlyEM collaborators www.janelia.org/project-team....

Excellent opportunity for an enthusiastic #postdoc to join Kate McDole in @cellbiol-mrclmb.bsky.social, using interdisciplinary approaches to investigate tissue formation during early organogenesis in mouse embryos.
More info: www.nature.com/naturecareer...
Closes 20 OCT
#ScienceJobs #PostdocJobs

LMB PhD studentship available in the Baum lab to use informatics to infer cell structure from genomic data in collaboration with the brilliant Tom Williams. If you write to me and I don’t reply - try again - the spam filter is hungry…

📣📣We're seeking a postdoc to join us at the @mrclmb.bsky.social to investigate neuroimmune interactomes in tumour & viral immunity.
If you find fascinating & want to learn about #neuroscience & #immunology, tracing neurons, molecular biology & #flowcytometry, apply!
🧠🫁👀🩸🔬
mrc.tal.net/vx/mobile-0/...

Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging

www.biozentrum.unibas.ch/open-positio...

#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging

Bioimage Analysis Specialist | King's College London

BioImage analysis friends - King's are recruiting for a full-time, permanent facility position! Come and work with fun microscopes and fun people (and me!) - please share! www.kcl.ac.uk/jobs/126345-...

Latest imaging data from our completely re-designed ExA-SPIM system.

Expansion-assisted imaging (3X expansion, 0.3 NA) enables brain-wide imaging with high-contrast and <400 nm effective resolution.

We were also concerned by that, so I thought we could use a cleared tissue lens and use Kramers–Kronig clearing to tune n to be just right.

Yeah, that doesn't seem to work... The gel shrinks quite a lot. I have a few more tricks to try before we give up, but you might also want to play with it.

If you want to go further, then @adamkglaser.bsky.social is the person to talk to!

bsky.app/profile/adam...

@miguelcmestre.bsky.social is at the GEF25 with a poster on how we use them if you want a chat. He might also be able to give people a sneak-peek into the high-expansion-factor sectionable gel chemistries he's now working on to increase the effective working distance further still.

We're big fans of the Zeiss 40x/1.0 with 2.5 mm WD (www.micro-shop.zeiss.com/en/us/shop/o...) and the Nikon 60x/1.0 with 2.8 mm WD (www.microscope.healthcare.nikon.com/en_EU/produc...). Both work great on our inverted microscopes when using an FEP coverslip (www.biorxiv.org/content/10.1...).

Live stream of the talks at #GEF25! Experience the best of ExM first hand! Tomorrow 9 am it is me btw. Monday 9 am Ed Boyden himself!

We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM.

Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩
#RNA #cryoEM

The Molecular Brain Mapping group at the MRC-LMB is hiring! 🌈🧠

I'm looking for people who are excited about revealing the many molecular layers of the "hidden connectome" with expansion microscopy, in a highly intersectional environment exploring ideas in meta-science.

mrc.tal.net/vx/mobile-0/...

The Molecular Brain Mapping group at the MRC-LMB is hiring! 🌈🧠

I'm looking for people who are excited about developing multimodal analysis and visualization tools to capture the "hidden connectome," in a highly intersectional environment exploring ideas in meta-science.

mrc.tal.net/vx/mobile-0/...

Join the LMB's PhD programme! Applications now open for October 2026 Deadline 2nd December 2025

Calling all prospective PhD students! Why not consider the LMB for your PhD?
Applications are now open!
www2.mrc-lmb.cam.ac.uk/students/int...
General deadline: 2nd DEC
US Gates Scholarship deadline: 15th OCT