Daniel Utzschneider

TGFβ-driven, HOBIT-dependent tissue-residency programs promote tumor-infiltration of CD8 T cells, but disruption of TGFβ in these tumor-infiltrating cells enhances tumor control @natimmunol.nature.com www.nature.com/articles/s41...
www.nature.com/articles/s41...

Congrats @yannick-alexandre.bsky.social and team. Great study

We're looking for an experienced lab manager to join our wonderful team investigating fundamental T cell biology 🤓
careers.pageuppeople.com/513/cw/en/jo...

Congrats Jan!

Great meeting to (be) lock(ed) in!

We are recruiting a group leader in laboratory research at Peter Mac Cancer Centre in
Melbourne, Australia 🔬🦘💥

Work in a cutting edge research environment in a vibrant world city!

We value research excellence, creativity and diversity.

Join us!

careers.petermac.org/job/MELBOURN...

Trump 2.0: an assault on science anywhere is an assault on science everywhere US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.

Inexplicably, US administration has launched an unprecedented assault on science, on research institutions & on vital international organizations & initiatives.

An assault on science anywhere is an assault on science everywhere; the global community must unite
🧪
www.nature.com/articles/d41...

Check out our new paper!

Congrats @niclag.bsky.social @pzareie.bsky.social and team! 🎉

In the media over the weekend, groundbreaking research from Peter Mac & The Doherty has uncovered a new way to enhance the immune system’s ability to fight cancer.

Work at Peter Mac led by @JohnstoneRicky and Dane Newman. More via @australian or here: www.petermac.org/about-us/new...

Thanks Steve!

Very excited about this collaborative study between @petermaccc.bsky.social @danielutzschneider.bsky.social and Kallies lab

ID3 defines stem-like T cells with high developmental potential that sustain T cell responses to chronic infection and cancer
www.science.org/doi/10.1126/...
@sciimmunology.bsky.social

Very happy to share our new work!

Not sure I would be able to focus on the pub😂

Thank you to all the collaborators, including @rauschlisa.bsky.social, @ajithvasanthan.bsky.social, @bendinglab.bsky.social and everyone @thedohertyinst.bsky.social & @petermaccc.bsky.social

How could this work?

IL-1 cytokines expand ID3+ stem-like T cells in vitro, boosting their ability to sustain T cell responses in chronic infections & cancer.

This could pave the way for next-gen T cell therapies with enhanced longevity & efficacy. Exciting possibilities ahead!

ID3+ T cells in acute settings show unique stem-like features, including the ability to sustain long-term immunity and exclusively form #Tpex cells in chronic infection & cancer.

Could this improve durability in T cell therapies? We think so! 🧬

#Tpex cells are key to sustaining T cell responses to chronic infection & cancer. Can we learn from #Tpex cells, and harness stem-like T cells in acute infection to improve chronic immune responses?

Yes! T cells identified in acute LCMV expressing ID3 and LY108 shape durable therapies

Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression ID3 defines stem-like T cells with high developmental potential that sustain T cell responses to chronic infection and cancer.

Excited for our lab's FIRST paper #ScienceImmunology! 🎉

Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social

Huge thanks to reviewers & @claireolingy.bsky.social 🙌

#Tpex #onthescoreboard

www.science.org/doi/full/10....

Really enjoyed writing this News & Views for @natimmunol.bsky.social on @tcellogic.bsky.social & teams recent @science.org paper - the first one 😉

Really beautiful work!!!

www.nature.com/articles/s41...

A photo of coastline called the great Ocean road in Victoria Australia. The water is blue and torquise. The waves crash on to rocky alcove and sandy beach. The conference is hosted at one of the local towns.

🐳 Join us in sunny Lorne, Australia next month, 19-21 Feb, for the @theviin.bsky.social Infection and Immunity Conference. 🪼 Absolutely great line-up this year! In person (sea-side🐚) and virtual registration options available too. Don't miss out- www.lorneinfectionimmunity.org/registration

Share your #cancer #immunology research w/ #CSCancerImmunity2025 organizers Ignacio Melero, Ira Mellman, Fabiola Rivas @cp-immunity.bsky.social
& Montse Rojo de la Vega @cp-cancercell.bsky.social . hubs.li/Q033hK4y0

Special thanks to my PhD mentor Rafi, my co-first author, Rajesh Valanparambil, and all the rest of our co-authors.

Image above shows CD8 T cells asking a crystal ball to predict infection outcome. Credit: ChatGPT4

Also see our companion paper from Dietmar Zehn's lab: tinyurl.com/yck3mdup

Two studies published in @nature.com today showing that Tpex-like cells develop independent from acute or chronic infection

#Tpex

www.nature.com/articles/s41...

please include 😀

We’ve jumped on board fully here on 🦋
A starter pack of those working on our favourite cell … the T cell 🥰🙈🥰

If you want an add let us know

go.bsky.app/8B5P25c

I made a starter pack for those of us interested in or working on T cells. Let me know if you would like to be added or know somebody that should be added.

Looking forward to scientific discussions and updates on our favorite immune cell type!

Congrats @nanaborsa.bsky.social
Amazing news!!!