James Reading

Pre-Cancer Immunology The Pre-Cancer Immunology Lab (James Reading Lab) is mapping pre-invasive T cell dynamics during carcinogenesis to detect and intercept cancer development.

🚨 PhD Position available in our lab 🚨 exploring the power of blood immune multi-omics to detect lung cancer years prior to clinical diagnosis in a unique cohort of >10,000 CT screened individuals.
✅ Wet & dry lab
✅ September 2025 enrolment
✅ UK tuition fees only

www.ucl.ac.uk/medical-scie...

🚨 Final day to send in your application to join @giampazolias.bsky.social & the Cancer Immunosurveillance group @cruk-mi.bsky.social.

Don’t miss this great opportunity!
@mcrcnews.bsky.social

Clonal driver neoantigen loss under EGFR TKI and immune selection pressures - Nature We show the evolution of a case of EGFR mutant lung cancer treated with a combination of erlotinib, osimertinib, radiotherapy and a personalized neopeptide vaccine targeting somatic mutations, including EGFR exon 19 deletion.

Nature research paper: Clonal driver neoantigen loss under EGFR TKI and immune selection pressures

https://go.nature.com/4k6SCQD

Interested in investigating the principles that regulate the establishment of tumour environments that promote or inhibit the anti-tumour function of the immune system? Our group is currently recruiting a postdoctoral fellow.
Learn more about our research 👇
www.cruk.manchester.ac.uk/research-gro...

#hiring #postdoc
We are looking for a postdoc to work on anti-tumor gamma delta T cells in breast cancer metastasis mouse models. Apply here:
www.gla.ac.uk/explore/jobs...

Analysis of multi-condition single-cell data with latent embedding multivariate regression - Nature Genetics Latent embedding multivariate regression models multi-condition single-cell RNA-seq using a continuous latent space, enabling data integration, per-cell gene expression prediction and clustering-free ...

How to do differential expression with scRNAseq data? State of the art is "pseudo-bulk" analysis with RNA-seq methods like edgeR or DESeq2, where "cell type" is encoded as discrete categories. Biologically, discrete categories are not always the most appropriate concept.(1/3)
doi.org/10.1038/s415...

Interesting work, it's becoming clear that @santiagozelenay.bsky.social's 2015 work on the COX-PGE axis' role in tumor immune evasion is robust (and also that we really need to focus on type I IFN in anti-tumor immunity).
#Immunology #Immunotherapy #Immunosky

A very rare position for an immunology professorship at Cambridge. Something to think about!

www.jobs.cam.ac.uk/job/49381/

Crystal structure of the human LAG-3–HLA-DR1–peptide complex The structural basis of how the immune checkpoint molecule LAG-3 binds peptide HLA-II is resolved.

This week in #Science #Immunology: Jan Petersen, Jamie Rossjohn, & colleagues have solved the #CrystalStructure of human #LAG3 – #HLADR1 – #peptide complex, a major target of #ImmuneCheckpoint #therapy!

What a sensational line up!

tcrBLOSUM: an amino acid substitution matrix for sensitive alignment of distant epitope-specific TCRs Abstract. Deciphering the specificity of T-cell receptor (TCR) repertoires is crucial for monitoring adaptive immune responses and developing targeted immu

🚀 Advancing T-cell receptor (TCR) research! We developed tcrBLOSUM, a specialized substitution matrix for sensitive alignment of distant epitope-specific TCRs. Find out how our findings expand TCR analysis: doi.org/10.1093/bib/... #Bioinformatics #Immunology #AIRR with @pmeysman.bsky.social

Every exemplar, case and occurrence needn't be a vignette

Wonderful work @barralab.bsky.social on the role of NKT cells in gut epithelial cell homeostasis. Huge congrats to Patricia, the team and @martalebrusant.bsky.social a rising unconventional T cell superstar that we are lucky to have slaying it in our lab!

IFN-γ-dependent regulation of intestinal epithelial homeostasis by NKT cells The crosstalk between immune and epithelial cells is vital to maintain intestinal homeostasis. Lebrusant-Fernandez et al. identify NKT cells in the small intestine as key regulators of epithelial biol...

Our first 🦋 post! Very happy to share our latest paper just out in Cell Reports, exploring the crosstalk between immune and epithelial cells in the gut. Check it out!
@vivianlilab.bsky.social @kingscollegelondon.bsky.social

www.cell.com/cell-reports...

Totally agree. The immune system is an excellent biosensor and recorder of past experiences. UPenn Immune Health www.med.upenn.edu/immunehealth/ together with our Colton Autoimmunity Consortium www.coltonconsortium.org is profiling Immune Health of 1000's of subjects. Many ways to work towards a GIO