Atlas of Variant Effects Alliance

Our @varianteffect.bsky.social annual reports summarize, celebrate and showcase our collective work.
Read the latest 🔖 zenodo.org/records/1833...
View them all 📖 www.varianteffect.org/annual-repor... #AnnualReport #GlobalAlliance
#FunctionalGenomics #Consortium

Today at 9am Pacific | 12pm Eastern! www.varianteffect.org/seminar-seri...
#CRISPR #FunctionalGenomics #ScienceSeminar

A recent preprint introduces MaveMD, a clinical interface for MaveDB that integrates MAVE data with ClinVar and ClinGen to support variant classification and reduce VUS uncertainty.

Uncover the science behind it:  www.medrxiv.org/content/10.1...

brotmanbaty.org/news/ave-all... @brotmanbaty.bsky.social

Momentum and connections is exactly right!
Excited to see the impact highlighted in the 2025 Annual Report. 👏🏼

Two #CRISPR talks on Feb3!
1️⃣ Stephan Riesenberg (Group Leader, Max Planck Leipzig): CRISPR-mediated generation of genetic variants for functional analysis.
2️⃣ Yuriy Baglaenko @baglaenkolab.bsky.social: Causal variants with CRISPR editing in primary human cells www.varianteffect.org/seminar-seri...

We’re happy to share our 2025 Annual Report!
A year of "momentum and connections"!
➡️ zenodo.org/records/1833...
#AnnualReport #GlobalAlliance #FunctionalGenomics #VariantEffect #Community

Coming up! with Yuriy Baglaenko @baglaenkolab.bsky.social and Stephan Riesenberg @mpi-eva-leipzig.bsky.social
Details ℹ️ ➡️ www.varianteffect.org/seminar-seri...

The recording is now available www.youtube.com/watch?v=domr...

Join us tomorrow! with @mehurles.bsky.social @sangerinstitute.bsky.social and @maitreya.bsky.social @uwgenome.bsky.social
Info and Link to join:
www.varianteffect.org/seminar-seri...

We post here on BlueSky, but be sure to also follow us on LinkedIn! www.linkedin.com/company/atla...

🧬 New VESS talk alert! "Understanding GPCRs with massive mutagenesis" with Taylor Mighell @crg.eu @sangerinstitute.bsky.social @embo.org @cam.ac.uk
Watch the Dec 2 seminar now on YouTube
#VariantEffects #GPCR #FunctionalGenomics
🎥 www.youtube.com/watch?v=lSFt...

We have a special event coming up in early January.
Learn more and Save the Date!
ℹ️ www.varianteffect.org/event/firesi...

Happening now!
Zoom link here: www.varianteffect.org/seminar-seri...

Update for today's seminar: Presentation with @taylor-mighell.bsky.social (postdoc w/ @benlehner.bsky.social) on "Understanding GPCRs with massive mutagenesis"
(Thea will present with us at a later date)
Find the Zoom link on our website: www.varianteffect.org/seminar-seri...

Tomorrow!
www.varianteffect.org/seminar-seri...

Did you know that we have a Variant Effects Seminar Series playlist on YouTube? Tune in to watch previously recorded talks at your leisure 📺☕ www.youtube.com/playlist?lis... #FunctionalGenomics #Seminar

Be sure to submit your abstract by December 1st! #VariantEffect26 #abstract #final #deadline
Please note that there will be no extensions ⌛
ℹ️ www.mss2026.org

MSS26 - Abstract submission This form will enable you to submit an abstract for consideration for presentation at the 2026 Mutational Scanning Symposium & Workshop (MSS26). MSS26 will be held at the Aikenhead Centre for Medical ...

The FINAL Deadline to submit your #VariantEffect26
#abstract is ⏰🗓️🔜 December 1st, 2025!
ℹ️ www.mss2026.org
📝 docs.google.com/forms/d/e/1F...

Also! We'd love your help in promoting this event in the #Australia #Australasia region! Topics and programming will be of interest to the #FunctionalGenomics #Genomics #Clinical #Research #Community ℹ️https://www.mss2026.org

#VariantEffect26 will be in Melbourne Australia! 🐨
Note that there will be a computational modeling and a clinical variant interpretation workshop!!
Discounted tickets available for participants from LMICs.
More info and to register www.mss2026.org

If you are planning to attend the Mutational Scanning Symposium (and companion workshops!) we recommend that you register as soon as possible to secure your spot!
ℹ️ www.mss2026.org
Keynotes! @mehurles.bsky.social @maitreya.bsky.social
#VariantEffect26 #Symposium #Workshop #RegisterNow

🧬 #SponsorshipOpportunity #VariantEffect26
For more info reach out directly to @muffley.bsky.social
or inquire here 📧 www.mss2026.org
We'd love to have your support!

The image is a promotional graphic for a "Fireside Chat" event organized by the Variant Effects Seminar Series and the AVE Alliance. The background is light gray, and the text is in dark gray and green. At the top, there is a stylized image of a fireplace with flames. Below, bold text reads "Fireside Chat," with an invitation to join on January 6th, 2026, featuring Dr. Maitreya Dunham and Dr. Matthew Hurles discussing MAVEs in clinical space and model organism systems. The date and time are highlighted in dark and light green ovals: "01.06.26" and "9:00AM (Pacific)." To the right, the Atlas of Variant Effects logo is displayed featuring stylized DNA strands formed by interwoven lines. At the bottom, there are two photos: on the left is Dr. Maitreya Dunham, with the text "Maitreya Dunham, University of Washington," and on the right is Dr. Matthew Hurles, with the text "Matthew Hurles, Wellcome Sanger Institute."

Join us for a special @varianteffect.bsky.social Fireside Chat on Jan 6th, 2026 (9-10am Pacific) w/ @maitreya.bsky.social (@uwgenome.bsky.social) & @mehurles.bsky.social (@sangerinstitute.bsky.social)

Visit www.varianteffect.org/event/firesi...
for more info and to add this event to your calendar

Coming up!
Rewriting Cancer’s Script:
Insights from Saturation Genome Editing
🗓️ 25 November 2025 4 PM CET | 7 AM PST
@twistbioscience.com #Webinar
with @davidjadams.bsky.social @sangerinstitute.bsky.social
Register for this free webinar here:
tinyurl.com/RewritingCan...

If you are planning to attend the Mutational Scanning Symposium next year in Melbourne, we recommend that you register as soon as possible to secure your spot!
🗓️ March 25-27, 2026
➡️ Register now
📝 Submit your abstract
🇦🇺 Apply for your Visa
🛫 Book your flight
ℹ️ ➡️ www.mss2026.org
#VariantEffect26

🎙️ Next up Dec 2 in VESS!

Thea Schulze (Lindorff-Larsen Lab): Predicting mutated protein abundance @tkschulze.bsky.social

Taylor Mighell (Lehner Lab): Massive mutagenesis to understand GPCRs @taylor-mighell.bsky.social

🔗 More info at varianteffect.org/seminar-series
@varianteffect.bsky.social

2026 Mutational Scanning Symposium & Workshop will be here before you know it! Register now to secure your spot and get a ticket 🎟️ for the conference dinner at Melbourne Museum! 🦕 tinyurl.com/MSS26Registr... #VariantEffect26 #Dinosaurs #RegisterNow

🗓️Abstract Deadline Extended
to December 1st, 2025!
#VariantEffect26
ℹ️https://www.mss2026.org

Coming up next week!
Free! No registration required!
ℹ️ www.varianteffect.org/seminar-seri...