Carlo Palacios

Finally published
🆕🔥DOTS RCT
Among participants with complicated S aureus bacteremia who achieved blood culture clearance, dalbavancin was not superior to standard therapy for achieving a more desirable outcome at day 70 #idsky
jamanetwork.com/journals/jam...

Let’s give it up for some fungal talks! #WTC2025

Weekly Screening of Circulating Mucorales DNA and early treatment in Severely Burned Patients Improves Survival: Real-Life Bi-center Experience in France Early serum Mucorales DNA detection in severely burned patients enables faster diagnosis of invasive wound mucormycosis, reducing 100-day mortality, partic

Weekly Screening of Circulating Mucorales DNA and early
treatment in Severely Burned Patients Improves Survival:
Real-Life Bi-center Experience in France

Emmanuale Faure... Alexandre Alanio and @sarah-delliere.bsky.social 

#IDSky #MedMycoSky #IDDx

academic.oup.com/cid/advance-...

🔥Finally published🔥
IDSA Guidelines on the Treatment and Management of Complicated Urinary Tract Infections (cUTI)
#idsky
www.idsociety.org/practice-gui...

In the latest video in our partnership with @glaucomflecken.bsky.social, the BALANCE trial comparing 7 days of antibiotic treatment with 14 days of treatment in patients with bloodstream infection is explained. Access the article for free: nej.md/DrG19

Suggested strategies for treatment of resistant/refractory CMV disease for transplant recipients

doi.org/10.1016/j.ij...

#IDSky

Our latest episode collabs with @txidfellows.bsky.social to discuss donor call - are you prepared?! Listen to @rebeccakumar.bsky.social @courtharrismd.bsky.social @chelseagorsline.bsky.social share their approach as they answer a few pages.

Then check out: pubmed.ncbi.nlm.nih.gov/37937964/

#idsky

@steventong.bsky.social presents the results of the PSSA domain of the SNAP 🫰 trial - the worlds largest trial of staph aureus bacteremia - at #ESCMID2025

fluclox resulted in higher mortality and more AKI compared to penicillin for PSSA

#SNAP PSSA silo results #escmidglobal
Should we be using Benzylpenicillin all the time? Looks superior and has less AKI

The most anticipated RCT in ID
🔥SNAP RCT🔥The largest RCT 2 date in SA bactermia
N:1341
Cefazolin Vs ASPs ((flu)cloxacillin) for MSSA bacteremia
Cefazolin is non-inferior (90d mortality)& less AKI than ASPs
A practice-changer RCT that must change the guidelines
#ESCMIDGlobal #IDSky

Graphical abstract

Plant-Based Diets & Climate Change, A Perspective for Infectious Disease Providers

“This review advocates for the adoption of plant-based diets as a dual strategy to combat climate change & improve health outcomes, particularly in the context of infectious diseases”
academic.oup.com/ofid/advance...

【Trauma related fungal infection】

With tremendous support from #MayoClinicINFD #OrthoID faculty, I delivered the Grand Round today!

@msgerc.bsky.social @pascalisid.bsky.social

“How bad can it be to have an anti-vaccine zealot leading our health agencies?” 🤦🏻‍♂️🤦🏻‍♂️🤦🏻‍♂️

Reaffirming the JAMA Network Commitment to the Health of Patients and the Public In the first month of the new administration responsible for leading the US, the executive branch has issued a flurry of orders, including ones associated with the dismissal or resignation of tens of ...

Reaffirming the JAMA Network Commitment to the Health of Patients and the Public

jamanetwork.com/journals/jam...

Notes from the Field: Seroprevalence of Highly ... This report describes evidence of recent highly pathogenic avian influenza infection among three veterinary practitioners.

3 (of 150) bovine vets had serologic evidence of H5N1 despite: 1) no known exposure to infected animals; 2) no respiratory symptoms.

Clearly there is a broad spectrum of clinical disease, and not all H5N1 is "highly pathogenic".
(p.s. good to have mmwr back!) www.cdc.gov/mmwr/volumes...

Reports from the field indicate that despite claims from the administration that funding for PEPFAR and USAID's healthcare initiatives has been restored, this is not accurate. Please contact your representatives today. ⚕️💉🏥https://idsociety.quorum.us/campaign/109393/

There is testing for specific infections we send to the cdc. For example sequencing malaria parasites to determine species and things like leishmania test amongst others. With the gag order our cdc colleagues can run testing but can't report results.

Very important to see local/state papers covering this. Here is the story from the Pittsburgh Post-Gazette to add to the Alabama story www.post-gazette.com/business/hea...

The United States by virtue of a bipartisan commitment to biomedical research created one of the most vibrant, productive research ecosytems in the world. People came from all over to study here, do research here. It was a monumental accomplishment by both parties. 1/

"The professors are the enemy"

- Chairman Mao Zedong

<Checks notes>

Ooops, scratch that,

it was JD Vance

Um, guys...

NIH indirect costs were just capped at 15%

Until now, they've been ~50-70%

ie for every $1 from NIH funding, the university gets another $0.50-0.70 to keep on the💡

Will devastate Universities & Med Centers

h/t @surtlab.bsky.social @prasad.bsky.social

Rubio claims that @USAID lifesaving assistance for health and humanitarian needs will continue. But his team just communicated that the entire agency will be imminently reduced from 14,000 to 294 people. Just 12 in Africa.

Unfortunately and unsurprisingly, the administration continues to charge ahead, running roughshod over norms, laws, and the dignity of and most basic protections for the people most vulnerable to infections. Many of the changes are summarized here, up to date as of Feb 4. Who will speak up, or better still, ACT UP for these individuals? The National Science Foundation has reportedly shared with program officers a list of forbidden "DEI"-related words that will result in grants being flagged. These include routinely used terms like "female", "biased", "systemic", "inclusion" and "exclusion" along with other words that specifically target vulnerable populations. While few clinical researchers rely on NSF grants, it can be reasonably expected that similar censorship with grants from NIH, CDC, etc is inevitable. USAID funding remains frozen, and in fact there are reports of efforts underway to eliminate the entire agency. The effects have already been devastating for programs dedicated to controlling TB, malaria, and HIV, among others. Despite claims that these would be exempt, distribution of antiretrovirals remains frozen. The Senate Finance committee advanced RFK Jr for confirmation as HHS Secretary. Kennedy's disdain for evidence-based medicine is no secret. He is a conspiracy theorist who engages in dangerous race-based pseudoscience. The IDSA has fallen short of other professional societies (e.g. the American Public Health Association, which represents 25,000 public health professionals) in calling for the outright rejection of RFK Jr's nomination. The CDC and NIH remain muzzled, unable to communicate with interstate or international agencies or the public. They have been instructed to recall submitted or accepted manuscripts to scrub objectionable language. They remain barred from traveling until at least the end of April. How will these actions affect our ability to detect and respond to infectious disease outbreaks?

Meanwhile, our members are experiencing significant moral injury, and some have expressed levels of morale that rival the nadirs felt during the worst of COVID19. Every day it is a new insult, the cumulative effect being the disassembly of public health protections and further marginalization of the most vulnerable in society. Reticence to call attention to ourselves, potentially putting our work in the administration's cross hairs, is entirely understandable. After all, we don't want to imperil existing and ongoing advocacy efforts, including those related to bolstering the ID workforce. A sober analysis would concede that the likelihood of any potential actions moving the needle on any of these issues is low. I would argue, however, that standing up for what is right is the most important thing we can do to reinforce our commitment to social justice and to our members and the patients in our care. What we can do and how we can do it is up for debate; some bold ideas have already been presented in the IDea exchange forum and I welcome further input from colleagues. What is certain is that as rank-and-file individuals, our voices can easily be dismissed, but as a trusted, bipartisan professional organization that represents >13,000 infectious diseases experts, we cannot be ignored, and we must not allow ourselves to cower in silence. The reality is that things are going to get worse, and standing up to the assault on public health will only get more difficult as the administration becomes further emboldened and the actions set in motion gather steam. In the words of John Lewis, "If not us, then who? If not now, then when?"

I am deeply disappointed by the subdued response of the Infectious Diseases Society of America (@idsainfo.bsky.social) to the dismantling of public health structures, both in the US & globally

Here's what I wrote in the closed listserv (response: 🦗) in hopes of stimulating discussion here #IDSky

Time for another #GenEpiBioTrain online training!
This time we will look into R programming!

𝗪𝗵𝗲𝗻? 17-20 February - each day from 09:00-12:30
𝗪𝗵𝗲𝗿𝗲? Online!
𝗛𝗼𝘄 𝘁𝗼 𝗲𝗻𝗿𝗼𝗹? Click here: bit.ly/3WLc1wj

#Rprogramming #Rlanguage #Training #Preparedness #IDsky #EPIsky #

Need more information?
⬇️ ⬇️ ⬇️

Remember that Europe (@ebi.embl.org) has mirrored all these services and they will keep on running. They look and feel a bit different but do the same thing. I think @ewanbirney.bsky.social should be able to confirm.

www.europepmc.org
www.ebi.ac.uk/jdispatcher/...

📢 #PAHO Epidemiological Alert #YellowFever in the Americas Region (3 February 2025)//Alerta Epidemiológica #FiebreAmarilla en la Región de las Américas 🌎🦟

www.paho.org/en/documents...

The Times identified more than 30 frozen studies that had volunteers already in the care of researchers, including trials of: malaria treatment in children under age 5 in Mozambique treatment for cholera in Bangladesh a screen-and-treat method for cervical cancer in Malawi tuberculosis treatment for children and teenagers in Peru and South Africa nutritional support for children in Ethiopia early-childhood-development interventions in Cambodia ways to support pregnant and breastfeeding women to reduce malnutrition in Jordan an mRNA vaccine technology for H.I.V. in South Africa

Trials abandoned due to the stop-work order on USAID-funded research:

#idsky

I have no clue why a CDC page on an Ebola outbreak should comply with a president’s executive order

CDC Posts, Then Deletes, Data on Bird Flu Transmission Between Cats and People (Gift Article) The data, which appeared fleetingly online on Wednesday, confirmed transmission in two households. Scientists called on the agency to release the full report.

SCOOP: Cats that became infected with bird flu might have spread the virus to humans in the same household and vice versa, according to data that briefly appeared online in a report from the Centers for Disease Control and Prevention but then abruptly vanished.

www.nytimes.com/2025/02/06/h...