Toth B.

A plodding little podocopida ostracod (seed shrimp), making light work of the sticky Phaeocystis globosa.
🦑 #plankton

Now you put her in charge of a squad of crossbow dwarves and have her train 24/7 with her crossbow as her weapon

GPUs are expensive but still cheaper than actors and artists

B-2 ✈️

A nicely round COS cell with its reticulated ER in yellow, blobby mitochondria in blue gathered at the center, and gray actin highlighting the contour of the cell

Branching out of the cytoskeleton: ER staining is tricky but when it works it's 🔥. COS cell labeled for mitochondria (blue), ER (yellow) and actin (gray) 🧪

the link is broken! I think it should read "https://www.microscopie.nl/" right?

3D image of cardiomyocytes with high-throughput expansion microscopy

High-throughput expansion microscopy takes shape.
https://elifesciences.org/articles/96025?utm_source=bluesky&utm_medium=social&utm_campaign=organic

Sexually dimorphic dopaminergic circuits determine sex preference Sociosexual preference is critical for reproduction and survival. However, neural mechanisms encoding social decisions on sex preference remain unclear. In this study, we show that both male and femal...

Receiving one or two doses of HPV vaccines prior to age 17, especially for those initiating before age 15, has comparable effectiveness against high-grade cervical lesions with those who received three doses. #Lancet

Open Access
www.science.org/doi/10.1126/...

Collage of the 24 Development cover images in 2024

📢Vote for the 2024 Development cover image of the year

@dev-journal.bsky.social featured 24 cover images in 2024. Now is the chance to pick your favourite!

Browse through the images and vote by 13 Jan:
https://thenode.biologists.com/vote-for-the-2024-development-cover-image-of-the-year/

#DevBio

Transcription

Credit: SmartBiology

Types of Headache

Source: #medics_AbuSaif #Healthline

Microscopy photo showing radial glia, neurons and macrophages in the neocortex

Electric fence or radial glia? These cells🟡 are present only during 🧠development in the neocortex and guide immature neurons 🟣to their final position! Microglia/macrophages in 🔵. It was supposed to be a #FluorescenceFriday, now a #SynapticSunday, maybe #MicroscopyMonday, depending where you are! 🤓

Remember my programmer friends, that your work has value.

Remember to write programs now and then, not for your boss, or your company, but solely for your own benefit.

You have the ability to craft faithful servants that will perform useful tasks until their silicon brains literally fall apart.

A dividing budding yeast cell in steel, bronze, and silver, with apatite gemstones for the chromosomes. The sculpture rests in my hand, a physical cutaway view with many cellular structures visible.

Closeup of the sculpture, centered on the spindle pole body, a tiny structure looking like a stack of pancakes from the side, embedded in the long curved nuclear membrane, tethering the spindle (a splayed bundle of silver branches each terminating in a jewel chromosome). The spindle structure is polished silver, lodged in the polished bronze of the membranes and surrounded by bronze endoplasmic reticulum, mitochondria, and other structures.

A favorite commission this year, a dividing cell with an extra detail. Colleagues of a retiring researcher commissioned me to add the specific structure she worked on—the spindle pole body—to the sculpture. Here it is close up, in sterling silver embedded in the bronze nuclear membrane. 🔬#SciArt

Breathing polluted air increases the risk of osteoporosis. #Science

Open Access
www.science.org/doi/epdf/10....

Rube Goldberg machine pill

SPLICER: a highly efficient base editing toolbox that enables in vivo therapeutic exon skipping - Nature Communications Exon skipping technologies remain hindered by aberrant splicing and low efficacy. Here, Miskalis et.al. developed SPLICER, a Cas9 base editor toolbox which enhances overall exon skipping efficiency an...

Gene editing tool reduces Alzheimer’s plaque precursor

"The application in live mice shows the improved efficiency of the tool, called SPLICER, over the current standard in gene editing technology, as well as the potential for application in other diseases."

www.nature.com/articles/s41...

TLDR: Academics from low-income backgrounds are more like to push the needle on science, but less likely to receive credit for doing so. 🥴

#econsky #academicsky

A snapshot of the scene in virtual reality. An avatar in the tailored trousers and long tailed jacket from around the 1840s stands between a stone fireplace with a crackling fire, and a large window with heavy drapes.

This morning, I saw #AChristmasCarolVR, which was a live production of the Dickens classic in VR! Social VR experiences (for me) have the excitement of computer games in the 1980s: the technology is accessible enough to reach a wide audience, and the limitations are a driver for a ton of innovation

Microplastics (driving is the major source) in the air may be leading to cancers and infertility.

Open access
pubs.acs.org/doi/10.1021/...

Tau (cyan) and tubulin (fire) are shown in a primary hippocampal neuron (or two).

For #FluorescenceFriday, tau (cyan) is shown along with microtubules in primary hippocampal neurons 🔬 #neuroscience #microscopy

🔬My first try on #FluorescenceFriday
Nice detail of a tissue-cleared kidney from neonatal mice.
-GFP is expressed in podocytes and pericytes.
-CD31 antibody highlights the branched blood vessels and glomeruli in red

Wonderful new work by @drewberry.bsky.social Beautifully animated and wonderful sound design #sciart

YouTube video by WEHImovies DNA Break Repair by Homologous Recombination (2024) Drew Berry wehi.tv

Delighted to publish my new molecular animation:

DNA Break Repair by Homologous Recombination

youtu.be/Xe-83tBcxhs

If you're at #ASCB2024 and want to learn more about my research on learning in single cells, please come to my talk "Probing the molecular substrates of memory in the single cell Stentor coeruleus" at 5:35 pm today!

This odd fish has 30 times as much DNA as humans—a new record for animals Lacking key genes that control selfish bits of DNA, the South American lungfish’s genome just grew and grew

A species of lungfish found in South America has claimed the title of the animal with the biggest genome sequenced so far.

Learn more: scim.ag/4gEQU6n

Setting up conference posters can be quite painful

What a coincidence that this old post should present itself to me now, when I'm bringing antifreeze proteins (and their beta-helical brethren) to Tuesday's #cellbio2024 art show! Come sproing for yourself!

beatascienceart.com/artshow2024/

PP1-Phactr1 Holophosphatase bound to it's substrate... (purple:active site, yellow and green:amphipathic pocket and hydrophobic pocket guiding substrate specificity).

PP1-Phactr1 holophosphatase bound to its substrate iRsP53.
#blender #sciart #molecularnodes