Deutsche Gesellschaft für Neurogastroenterologie & Motilität

The balance of fiber and protein intake has been largely overlooked

This timely review in @natrevgastrohep.nature.com updates factors that influence human digestion and absorption of protein in the small intestine and protein fermentation in the colon:

https://tinyurl.com/4ebkb6js

⏳ One month to go until #GMFH2026!

Join us in Porto, March 14–15, to explore the latest advances in diet & microbiome modulation in clinical practice.
👉 Register now and secure your spot
https://www.gutmicrobiotaforhealth.com/porto-2026-fourteenth-edition/registration/

😊 We welcome you to the next Immune Alliance Seminar on Feb 18, 2026, 9 am (in Germany) / 5 pm (in Japan), via zoom. You are cordially invited to attend. Registration is free. Register via: dgfi.org/immune-allia...

@zielinskilab.bsky.social @efis-immunology.bsky.social @iuis-online.bsky.social

Laboratoriummanager TARGID zoekt een enthousiaste laboratoriumtechnoloog.

We're hiring! 🧪
TARGID @ KU Leuven is looking for a Laboratory Manager to coordinate and support cutting-edge research on gastrointestinal diseases.
📍Leuven | ⏰ Apply by Nov 4, 2025
🔗 kuleuven.be/personeel/jobsite/jobs/60566238
#KULeuven #Hiring #Research

😱 The Belgian Week of #gastroenterology is currently rocking Antwerp!
🔬 listened to great #science
🫂 met new and old friends
🗣 one keynote from the lab on #ENS progenitor cells and aging

Thanks for hosting, Werend Boesmans!
#neurogastro

🧠 Study examines implications of shame for patient-reported outcomes in bowel disorders of gut-brain interaction
🔗 https://ow.ly/ojnb50Y7HTo

APC is recruiting a Postdoc to work with @lilykeane.bsky.social at UCC on a project focusing on how early-life microbiome perturbations shape brainstem microglial development during the neonatal period.
#microbiome #glioma #cancer #jobfairy #researchjobs #ucc
Full Details: bit.ly/4tlQjxO

⏰Final Call!! Three days left to apply for #LBBB2026
Don't miss out on your opportunity to attend the best early career meeting in the #neurogastroenterology field.
www.lbbb2026.com/apply
@dgnm.bsky.social @gastronauts.bsky.social

In Tübingen ging es dann 2017 im brandneuen @neuromadlab.bsky.social mit Nils Kroemer ganz tief in die Materie. Thematisch drehte sich alles um die Darm-Hirn-Achse und wie die metabolischen Signale, die der Vagusnerv weiterleitet, den Körper im Gleichgewicht halten.

Looking back on 2025, inspired by the Year in Reviews starting on p112.

Our February ISSUE is live! Year in Review 2025, gut virome, gut-brain axis, liver-brain axis, cancer registries in Africa, and much more!

www.nature.com/nrgastro/vol...

⏩#GLP1 #Serotonin, the body’s multitasking maestro #DGBIs💡 🎯A blueprint for developing #orally active small-molecule secretagogues capable of activating the body’s own incretin sensors & gut-brain axis👏 📢The advent of GLP-1–based therapies has reshaped modern metabolic medicine, providing unprecedented efficacy in treating diabetes and obesity. Yet, these advances rely heavily on injectable hormone mimetics #semaglutide #tirzepatide 🎯Transform EC and L cells into tunable therapeutic switches—enabling mechanism-based, physiological treatments for diabetes, obesity, and disorders of gut–brain communication‼️ 🎯Through #neuropod synapses, EECs transmit real-time information about nutrient composition to the brain—forming a crucial component of #interoception, the body’s sense of internal state 🎯A detailed map of human enteroendocrine cell function & receptor signaling—laying the foundation for oral therapies that stimulate endogenous hormone secretion🌟 ⏩Description and functional validation of human enteroendocrine cell sensors @ScienceMagazine👏 👉 https://www.science.org/doi/10.1126/science.adl1460

Dive deep into our latest #GastroDigest @aga-gastro.bsky.social 🆕🔥
🚨Turning #GutSensors into Therapeutic Switches: A #Sensorome Roadmap for Metabolic & Gut–Brain🧠Interaction Disorders‼️ @amergastroassn.bsky.social 🙌
Prof. Kara Margolis🙏😇
👉 www.gastrojournal.org/article/S001...
#DGBI #GLP1 #Serotonin

A neurobiotic sense curbs feeding: a new frontier in gut–brain communication Nature Reviews Gastroenterology & Hepatology, Published online: 02 October 2025; doi:10.1038/s41575-025-01126-zIn a new study by Liu and colleagues, researchers demonstrated a novel neuroepithelial circuit in colonic neuropod cells through which a molecular pattern from resident microorganisms was relayed to the brain — a ‘neurobiotic sense’ by which the host adjusted its feeding behaviour by monitoring a gut microbial pattern.

ICYMI: New online! A neurobiotic sense curbs feeding: a new frontier in gut–brain communication

➡️ This #narrativereview provides an overview of functional dysphagia and details our unique multidisciplinary approach to these patients from the perspective of GI, speech-language pathologists, and GI psychologists at the USF Swallowing Center
🔗 https://ow.ly/uaVv50Y8rKU

KEY POINTS • Enterochromaffin (EC) cells release signaling molecules which can activate nearby sensory nerves.Whether this occurs via a conventional synapse for-mation is unknown. • EC cells rarely make contact with sensory nerves inthe upper gut but this frequency increases in the distal colon. • Neurite-like protrusiton on EC cells, named by some as “neuropods” are not a preferential site of contact with nerve fibres.

🆕 #Neuroepithelial landscape of #Enterochromaffin cells varies across #GI location‼️
✅EC cells rarely make contact with sensory nerves in upper gut but this frequency increases in distal colon👏
🎯 #Neuropods are not a preferential site of contact🔥
👉 onlinelibrary.wiley.com/doi/10.1111/...
#ANMS #ESNM

Intestinal macrophages modulate synucleinopathy along the gut–brain axis - Nature Muscularis macrophages, housekeepers of enteric nervous system integrity and intestinal homeostasis, modulate α-synuclein pathology and neurodegeneration in models of Parkinson’s disease, and understa...

Intestinal macrophages modulate synucleinopathy along the gut–brain axis www.nature.com/articles/s41...

📢Good news! If you need a little bit more time to apply for LBBB2026, we have you've got you covered!
New (and very final) deadline to apply is
🗓️9th Feb 2026
Don't leave it to the last minute and join us in Fusagasuga 🔗https://www.lbbb2026.com/apply

Die Woche neigt sich langsam dem Ende zu und ich möchte mit euch über etwas sprechen: das Bauchgefühl. Viele von euch kennen es wahrscheinlich, z. B. „Schmetterlinge im Bauch“, „Liebe geht durch den Magen“ oder „das Herz sinkt in die Hose“. Diese Phänome sind das Ergebnis der Darm-Hirn-Achse. 1/6

The gut-brain vagal axis governs mesolimbic dopamine dynamics and reward events Gut-brain vagal signals gate dopamine ensembles, reshaping reward and motivation beyond a brain-centric view.

"These findings challenge the traditional brain-centric view of reward processing, supporting a more integrated model in which vagus-mediated interoceptive signals intrinsically shape motivation and reinforcement."
Awesome work by @peppeganga.bsky.social & his team 👏
www.science.org/doi/10.1126/...

New APC paper in Nature Communications.

First author Tatiana Borodovich and colleagues examine how capsids drive large-scale DNA transfer in the gut. The study forms part of the research programme of Prof. Andrey Shkoporov's group at APC.
www.nature.com/articles/s41...
#Bacteriophage #Microbiome

https://www.lbbb2026.com/apply

📢REMINDER: The deadline to apply for LBBB2026 is Monday (2nd February)
📍The meeting takes place in Fusagasuga (Colombia) 31st October - 4th November
📬Apply Now to be part of a small meeting with big ideas
@dgnm.bsky.social

Parkinson’s may originate in the enteric nervous system, via muscularis macrophages containing misfolded α-synuclein that develop endolysosomal dysfunction & promote T cell expand/traffic to brain
www.nature.com/articles/s41... @nature.com @soyonhonglab.bsky.social @ucl.ac.uk @cmn-vib.bsky.social

The Impact of Cannabis Use in Gastroparesis: A Propensity-Matched Analysis of 41,374 Gastroparesis Patients
Kilani, et al.

📕 doi.org/10.14309/ajg.0000000000003479

Commensal fungus to the rescue of gut injury - Nature Microbiology A mouse commensal fungus, Kazachstania pintolopesii, secretes a protein, Ygp1, that promotes epithelial cell regeneration and healing in mouse models of intestinal injury, renewing the interest in pro...

Nice summary of a paper that revealed a healing role for a fungi that is part of the gut commensal microbiome 🧵🧪#MicroSky

Imidazole propionate: a novel driver of atherosclerosis and biomarker of subclinical disease A recent study reported that imidazole propionate made by gut bacteria contributes to atherosclerosis development, supporting its potential role as a biomarker of subclinical disease.

The gut microbiome offers new clues for better managing cardiovascular diseases

Findings in @nature.com show imidazole propionate made by gut bacteria contributes to atherosclerosis, supporting its potential role as a biomarker of subclinical disease:

A true highlight of my postdoc has been attending the LBBB meeting - the fact it’s just 30 other early career scientists makes it an incredible atmosphere to make connections and talk really in depth about science. Applications are due Feb 2nd, and I’d encourage you to apply if you’re eligible!

Targeting the gut's immune system could tackle early stages of Parkinson's New research reveals how Parkinson’s spreads from the gut to the brain, with the help of immune cells – offering a new potential therapeutic strategy – in a study in mice led by scientists at the UK D...

New research has revealed how Parkinson’s spreads from the gut to the brain, with the help of immune cells – offering a new potential therapeutic strategy – in a study in mice co-led by Dr @soyonhonglab.bsky.social & Dr Tim Bartels @ukdri.ac.uk @uclqsion.bsky.social @uclbrainscience.bsky.social

So great that this paper is finally out! Happy that I was able to contribute to this important study. Congratulations @seppedeschepper.bsky.social, @soyonhonglab.bsky.social, Tim Bartels and all co-authors!

New links between diet, gut microbiota and health
This plenary session at #GMFH2026 will explore how diet-driven microbiome changes translate into health outcomes, including cardiometabolic disease.

Secure your spot 👉https://www.gutmicrobiotaforhealth.com/porto-2026-fourteenth-edition/registration/

Pain-sensing neurons in the intestines play an important role in defending the body from threats.

New study led by the Artis Lab at @weillcornell.bsky.social shows TRPV1+ nociceptors in the gut activate tuft cells, leading to expulsion of parasites.

🔗 https://go.nature.com/4jTvO7k

Decreases in mucosally‐evoked tachykinin signaling pathways can explain age‐related reductions in murine colonic motility patterns The natural aging process can reduce lower bowel motility, leading to an increased incidence of chronic constipation. Aging reduces tachykinin signaling in the distal colon reducing colonic motility....

Also check out the other winners!

🔬 Best Basic Research Article
doi.org/10.1111/nmo....

🩺 Best Clinical Article
doi.org/10.1111/nmo....