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Stephen McLaughlin

@lmbbiophysics.bsky.social

Biophysics@MRC Laboratory Molecular Biology, Cambridge All opinions are my own

399 Followers  |  539 Following  |  10 Posts  |  Joined: 30.10.2023  |  2.1022

Latest posts by lmbbiophysics.bsky.social on Bluesky

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Research Group Leader in Chemical/Synthetic Biology at MRC Laboratory of Molecular Biology Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...

We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry ( www.jobs.ac.uk/job/DNW809/r... ) at the MRC Laboratory of Molecular Biology (LMB).

14.07.2025 12:09 β€” πŸ‘ 25    πŸ” 33    πŸ’¬ 0    πŸ“Œ 4
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Postdoctoral Fellow - Costa Lab Salary for this Role: From Β£45,500 with benefits, subject to skills and experience. Job Title: Postdoctoral Fellow - Costa Lab Reports to: Alessandro Costa Closing Date: 03/Aug/2025 23.59 GMT Job Desc...

Less than two weeks left to apply!

Postdoc positions in my lab to study

1. initiation of DNA replication.

2. chromatin replication/epigenetic inheritance.

Great for biochemists, biophysicists & structural biologists.

Deadline 3 August 2025.

crick.wd3.myworkdayjobs.com/External/job...

21.07.2025 14:57 β€” πŸ‘ 24    πŸ” 31    πŸ’¬ 0    πŸ“Œ 0
AstraZeneca, MRC Laboratory of Molecular Biology, Imperial College London, MRC Laboratory of Medical Sciences
Next Generation Biophysics Symposium 2025
Wednesday 3rd September 2025
Hybrid Symposium (Zoom & MRC LMB, Cambridge)
Keynote Speaker: Professor Cees Dekker
Registration open

AstraZeneca, MRC Laboratory of Molecular Biology, Imperial College London, MRC Laboratory of Medical Sciences Next Generation Biophysics Symposium 2025 Wednesday 3rd September 2025 Hybrid Symposium (Zoom & MRC LMB, Cambridge) Keynote Speaker: Professor Cees Dekker Registration open

Want to hear from experts about how new and emerging technologies can be harnessed to answer complex biological questions?
Don’t mis the 2025 Next Generation Biophysics Symposium on Wednesday 3rd September!
Find out more details and register here: www3.mrc-lmb.cam.ac.uk/sites/nextgen/

15.07.2025 11:22 β€” πŸ‘ 5    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0

Highly collaborative efforts that involved 6 lab members and the labs of @yiliangding.bsky.social and @rdaslab.bsky.social. We uncovered a telomerase dimer and its potential role in telomere maintenance.

11.07.2025 10:22 β€” πŸ‘ 59    πŸ” 17    πŸ’¬ 1    πŸ“Œ 0
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Great opportunity for a Research Support Officer to join @cellbiol-mrclmb.bsky.social, supporting @deriverylab.bsky.social in their studies of the molecular mechanisms behind receptor sorting in endosomes.
More info: www.nature.com/naturecareer...
Apply by 10 JUL
#ScienceJobs

23.06.2025 15:11 β€” πŸ‘ 17    πŸ” 9    πŸ’¬ 0    πŸ“Œ 0
A picture of 3 rows of people on steps at the MRC LMB. From left to right - top row: Akaash, Vic, Lara - Middle row: Kerrie, Manu, Paddy - bottom row: Meg  and Julie

A picture of 3 rows of people on steps at the MRC LMB. From left to right - top row: Akaash, Vic, Lara - Middle row: Kerrie, Manu, Paddy - bottom row: Meg and Julie

🚨 JOB ALERT 🚨
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired πŸ§«πŸ”¬
Apply now πŸ‘‰ www.nature.com/naturecareer...

#STEMCareers #ResearchJobs

23.06.2025 13:00 β€” πŸ‘ 47    πŸ” 32    πŸ’¬ 1    πŸ“Œ 5
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Excited for our program of speakers at Next Generation Biophysics 2025. Come join us as registration is now open either in person or online:
www3.mrc-lmb.cam.ac.uk/sites/nextge...

20.06.2025 13:34 β€” πŸ‘ 6    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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Measurements of molecular size and shape on a chip Size and shape are critical discriminators between molecular species and states. We describe a microchip-based high-throughput imaging approach offering rapid and precise determination of molecular pr...

Madhavi Krishnans lab with an absolutely amazing new measurement technique:
Measurements of molecular size and shape on a chip | Science www.science.org/doi/10.1126/...

09.05.2025 08:12 β€” πŸ‘ 37    πŸ” 10    πŸ’¬ 1    πŸ“Œ 1
Schematic illustrating the structural changes undergone by MukBEF SMC complex during DNA capture and ingestion.

Schematic illustrating the structural changes undergone by MukBEF SMC complex during DNA capture and ingestion.

How do SMC complexes capture DNA? πŸ§ͺ

Led by Frank BΓΌrmann, Jan LΓΆwe’s & Mark Dillingham’s groups have identified the directional loading mechanism the bacterial SMC complex MukBEF uses to capture & ingest DNA, & found a phage inhibitor to this pathway.

Read more: tinyurl.com/4s8nrrkk

#LMBResearch

31.03.2025 14:40 β€” πŸ‘ 62    πŸ” 32    πŸ’¬ 1    πŸ“Œ 1

Great opportunity in a fantastic lab

14.03.2025 15:49 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Structural mechanism of LINE-1 target-primed reverse transcription Long interspersed element-1 (LINE-1) retrotransposons are the only active autonomous transposable elements in humans. They propagate by reverse transcribing their mRNA into new genomic locations by a ...

Excited to share our latest work, led by the incredible @automnenine.bsky.social (now an Ass. Prof. at Princeton)! We uncover key insights into the retrotransposition mechanisms of LINE-1 ORF2p, the enzyme responsible for writing a significant portion of our genome.
www.science.org/doi/10.1126/...

06.03.2025 21:33 β€” πŸ‘ 112    πŸ” 38    πŸ’¬ 8    πŸ“Œ 3
Kelly Nguyen

Kelly Nguyen

Our latest β€˜Cell Scientist to Watch’ interview is with Kelly Nguyen @kellythd-nguyen.bsky.social @mrclmb.bsky.social. We learn about Kelly’s career, her advice on collaborative research and her passion for martial arts.
journals.biologists.com/jcs/article/...

10.02.2025 12:25 β€” πŸ‘ 37    πŸ” 9    πŸ’¬ 0    πŸ“Œ 1
Ingo Greger sat in front of a computer screen displaying an AMPA Receptor structure

Ingo Greger sat in front of a computer screen displaying an AMPA Receptor structure

Great position for a postdoc to join @igreger.bsky.social’s group in the LMB’s Neurobiology Division, using diverse methods to study synaptic AMPA glutamate receptors.
Read more about the job here: www.nature.com/naturecareer...
Apply by 20 FEB
#PostdocJobs #ScienceJobs

03.02.2025 09:48 β€” πŸ‘ 7    πŸ” 11    πŸ’¬ 0    πŸ“Œ 0
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Rising Talent Fellowship - MRC Laboratory of Molecular Biology RISING TALENT FELLOWSHIP The MRC Laboratory of Molecular Biology (LMB) is proud to launch the next application round of its three-year fully funded

The @mrclmb.bsky.social believes in the benefits of a diverse workforce, and is proud of its history in training next-gen scientists. Three-year postdoc fellowships are now available for those who self-identify as being from a (mixed) Black heritage background.
www2.mrc-lmb.cam.ac.uk/recruitment/...

29.01.2025 09:07 β€” πŸ‘ 25    πŸ” 16    πŸ’¬ 0    πŸ“Œ 0

We (Tim Coulson & Syma Khalid) are launching a new science podcast. We will discuss recently published work of world leading scientists in an accessible and non-technical style. Topics will include, AI, search for alien life, latest treatments for diseases, quantum computers, science of football.

26.01.2025 18:49 β€” πŸ‘ 31    πŸ” 12    πŸ’¬ 0    πŸ“Œ 4
Apply now!
LMB Rising Talent Fellowship
3-year postdoctoral fellowship for Black heritage scientists
Visit www.mrc-lmb.cam.ac.uk for more information

Apply now! LMB Rising Talent Fellowship 3-year postdoctoral fellowship for Black heritage scientists Visit www.mrc-lmb.cam.ac.uk for more information

The LMB Rising Talent Fellowship for Black heritage scientists is open for applicants!
With this 3 year postdoc position we want to enable scientists of Black heritage to learn & grow their experience.
To apply and for full details check here: www2.mrc-lmb.cam.ac.uk/recruitment/...β€―
Please share!

23.01.2025 12:19 β€” πŸ‘ 18    πŸ” 35    πŸ’¬ 0    πŸ“Œ 2
John Sutherland

John Sutherland


Congratulations to John Sutherland, Group Leader in the LMB’s PNAC Division, who has received the Award in Early Earth and Life Sciences – Stanley Miller Medal from @nasonline.org for his work investigating the chemical origins of life on Earth.

www2.mrc-lmb.cam.ac.uk/john-sutherl...

#LMBNews

23.01.2025 16:05 β€” πŸ‘ 7    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Check it out, is finally out!!

16.01.2025 10:44 β€” πŸ‘ 12    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
Experience Postgrad Life Sciences | Enhancing diversity among life scientists of the future

‼️Deadline 16th January 2025‼️Applications are open for the 2025 Experience Postgrad Life Sciences programme. Paid 8-week summer internships aimed to enhance diversity among life scientists of the future!! @cambridgebiosci.bsky.social @corpuscambridge.bsky.social www.exppg.lifesci.cam.ac.uk

07.01.2025 06:50 β€” πŸ‘ 3    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0

I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute.

Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now!

3 postdoc positions advertised soon.

11.12.2024 13:53 β€” πŸ‘ 185    πŸ” 50    πŸ’¬ 17    πŸ“Œ 1

If you missed this year's Next Generation Biophysics Symposium 2024 follow the link below to catch up on the talks.

28.11.2024 09:36 β€” πŸ‘ 8    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0
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Our article "MCM double hexamer loading visualized with human proteins" published in Nature today! β„οΈπŸ”¬πŸ§¬πŸŽ‰πŸ₯³

Great collaboration with John Diffley's lab. Congratulations to Florian Weissmann, Julia Greiwe and all other authors!

rdcu.be/d1F7m

27.11.2024 17:24 β€” πŸ‘ 170    πŸ” 44    πŸ’¬ 10    πŸ“Œ 5
Cryo-Et image of a brain extracellular vesicle

Cryo-Et image of a brain extracellular vesicle

Benjamin Ryskeldi-Falcon’s @brfalcon.bsky.social group in the LMB’s Neurobiology Division, with Karen Duff's group at the UK DRI, have discovered that tau filaments are tethered to the membranes of extracellular vesicles in #Alzheimers

Read more: www2.mrc-lmb.cam.ac.uk/cryo-et-reve...
#LMBResearch

26.11.2024 15:54 β€” πŸ‘ 23    πŸ” 9    πŸ’¬ 0    πŸ“Œ 1

Paris?

25.11.2024 11:17 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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I am excited to share this animation of the budding yeast inner kinetochore. Created for David Barford's lab @mrclmb.bsky.social

This DNA-binding protein complex acts as an anchor for the spindles that pull chromosomes apart during mitosis.
www.science.org/doi/10.1126/...

#blender #animation #b3d

25.11.2024 10:29 β€” πŸ‘ 135    πŸ” 31    πŸ’¬ 7    πŸ“Œ 3
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Lots of exciting PhD projects, including from my lab on how to make tubular organs, either in Drosophila or human renal organoids in culture! Apply!

22.11.2024 14:15 β€” πŸ‘ 11    πŸ” 9    πŸ’¬ 0    πŸ“Œ 2

Yay, our institute is here now too!

22.11.2024 15:58 β€” πŸ‘ 20    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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@mjafreeman.bsky.social's BlueSky starter packs for 'mechanistic' biologists

Here’s my spreadsheet of starter packs (>80!) related to broadly β€˜mechanistic biology’ plus some intriguing extras

Complete with collective nouns

I’ve been tracking these but now can’t keep up

Hope it’s helpful

2/2

docs.google.com/spreadsheets...

19.11.2024 21:45 β€” πŸ‘ 207    πŸ” 124    πŸ’¬ 40    πŸ“Œ 16
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A cartoon for you

16.11.2024 11:46 β€” πŸ‘ 9    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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As my lab's first post on Bluesky. If you are a UK Structural Biologist please come to our one day meeting on Friday 6th December
Lots of talk slots to be selected from abstracts.
Deadline for abstracts is TOMORROW: Friday 15th Nov.
bit.ly/4fDEqfZ

14.11.2024 10:52 β€” πŸ‘ 83    πŸ” 33    πŸ’¬ 0    πŸ“Œ 0

@lmbbiophysics is following 20 prominent accounts