Stimulating Brains

We had a wonderful time talking to @rolstonjohn.bsky.social, the Director of Epilepsy Surgery at Brigham & Women's Hospital. We talk about RNS for epilepsy, DBS for coma, traveling waves in the brain, stem cell therapy, closed loop DBS & more! Tune in 👇

stimulatingbrains.org/72-john-rols...

🧠 ⚡️ Preprint alert ⚡️ 🧠

I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.

Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...

Massive, Herculanean work by @laurenahart.bsky.social and Garance Meyer to compile and integrate findings from DBS for epilepsy (20 targets!) including meta-analytical evidence for optimal stimulation sites for the two main targets (ANT & CM). Preprint out now 👇👇

We are actively looking for an administrative position to help lead the newly founded @netstim.org at the University of Cologne – please spread the word and/or let us know if you know somebody that could be interested!

lnkd.in/eEbnXByJ

Excited to be featured as one of the best neuroscience podcasts on millionpodcasts: www.millionpodcasts.com/neuroscience...

@foxmdphd.bsky.social's legendary anticorrelation paper has now been cited over 10.000 times and this was reason for a dedicated PNAS cake. Congratulations again, Mike, for this unbelievable pioneering effort that opened up the then novel field of resting-state fMRI!

@braincircuits.bsky.social

Hard to keep track about all the great things our labmembers have achieved recently:

Happening today! We have two amazing speakers, Nicole Provenza and Martijn Figee who will share their thoughts on engineering for Neuromodulation and circuit based DBS for OCD respectively.

Be sure to tune in on May 29th, 12 noon EST/6:00 PM CET

Register here: partners.zoom.us/webinar/regi...

Are we on the cusp of moving beyond the levodopa challenge test to predict the best candidates and response to DBS in Parkinson's disease? We’ve long relied on the levodopa challenge to decide who’s a good candidate for deep brain stimulation but what if that test is only part of the story?

Is there a shared brain circuit target for tremor that transcends diagnosis and DBS site? New work by @lukasgoede.bsky.social @andreashorn.org @braincircuits.bsky.social says YES

Can brain injury cause the loss of visual imagination?

We studied #aphantasia due to brain injury. Lesions were in many different regions but 100% were connected to the fusiform imagery node - a region active during visual mental imagery @braincircuits.bsky.social

www.medrxiv.org/content/10.1...

Curious in an update on networks involved in treating tremor using neuromodulation? New study from the lab spearheaded by the one and only @lukasgoede.bsky.social out now at nature comms - nice summary thread below 👇👇

Tremor is a common symptom across many neurological disorders.

But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?

We think: yes.

Our study is out now in @natcomms.nature.com:

🔗 www.nature.com/articles/s41...

🧵 A thread.

New research from @lukasgoede.bsky.social @andreashorn.org & colleagues provides a robust, cross-condition tremor network that may guide both invasive & noninvasive neuromodulation strategies for #Parkinsons & essential tremor
www.nature.com/articles/s41...

Is there a role for noninvasive "network" stimulation (multifocal tDCS) to evaluate candidates for deep brain stimulation?

@lukasgoede.bsky.social says yes – new study here:

onlinelibrary.wiley.com/doi/10.1002/...

A 🧵

@netstim.org @braincircuits.bsky.social @lead-dbs.org

Patient Selection in Deep Brain Stimulation: A Role for Transcranial Direct Current Stimulation to Enhance the Levodopa Challenge? Dopaminergic medication and deep brain stimulation (DBS) improve motor symptoms in Parkinson's disease (PD), but levodopa response alone may not predict DBS outcomes. We retrospectively analyzed 19 P...

Patient selection for Deep Brain Stimulation (DBS) is crucial.
Are there ways to improve it?

In our new study, we found hints that non-invasive brain stimulation might enhance the levodopa response
- and serve as an additional marker for DBS outcomes.

doi.org/10.1002/acn3...

A thread. 🧵

New insights on tremor therapeutic sweetspot and tract this time in FUS thalamotomy, congrats @andreashorn.org and team

First Fiber Filtering study using MRgFUS lesions (instead of DBS Stimulation Volumes)! 👇👇

MR guided focused ultrasound surgery is an effective and uprising treatment option for Essential tremor. But where is the optimal site to sonicate? Which spots to avoid due to side-effects?

@science.org @braincircuits.bsky.social @netstim.org

– a thread🧵!

www.science.org/doi/10.1126/...

Mark your calendar: May 29 🧠

@nicoleprovenza.bsky.social & @mfigee.bsky.social are joining Stimulating Brains this month!

Register now 👉 stimulatingbrains.org/talk-series/

When modeling volumes of tissue activated in subthalamic DBS for clinical outcomes, does it matter whether we process data in native or template space? Julianna Pijar and Clemens Neudorfer say No in the Brain Stimulation Journal:
doi.org/10.1016/j.br...

Thank you @ruoyu-rachel.bsky.social for producing the episode!

It was a great honor to talk with the founding editor of Brain Stimulation, Dr. Harold Sackeim!
Beyond the past, present and future of ECT, we covered the entire field of neuromodulation.

Priceless insights from a key leader in the field!

Tune in here 👇

stimulatingbrains.org/71-harold-sa...

Truly inspiring episode about a life lived in neurosurgery across 🇨🇦 and the 🇺🇸, from ventriculography- & frame-based procedures including ablative lesions in neuro & psych to intraoperative MRI all the way to carrying out over 600 lesions using MR guided focused ultrasound. Tune in below 👇👇

Join us on Thursday, 12 PM ET to hear more of Dr. Rees Cosgrove's thoughts on the evolution of functional neurosurgery! partners.zoom.us/webinar/regi...

We had a truly inspiring and insightful conversation with Dr. Rees Cosgrove, Director of Epilepsy and Functional Neurosurgery at @brighamandwomens.bsky.social & Professor of Neurosurgery @harvardmed.bsky.social

Rediscovering the lost art of brain lesions…!

stimulatingbrains.org/70-rees-cosg...

🧠 Big brains, big moves!
Join us 📆 April 24 for a Stimulating Brains sesh with Dr. Rees Cosgrove & @bassamalfatly.bsky.social ⚡️
We will dive into topics of mapping causal brain networks & the evolution of movement disorder surgery!
Where: partners.zoom.us/webinar/regi...
🕛 Thurs, 12 PM ET / 6 PM CET

Probably the most insightful and most important paper on physiomarkers of subthalamic DBS in a long while. Bravo @julianneumann.bsky.social @tsbinns.com and team!!

Out at @natcomms.nature.com:
www.nature.com/articles/s41...

Follow this interesting study led by @bahnebahners.bsky.social and @andreashorn.org using MEG‑LFP data to investigate cortico‑subthalamic coupling in Parkinson’s disease. The study showed that the optimal DBS response network defined by fMRI operates in the high‑beta band.
Happy to be part of it!

Research defined the optimal DBS response network in STN-DBS for Parkinson’s Disease in a spatial domain.

Other research defined physiomarkers for DBS response locally, in a temporal domain.

However, nobody has analyzed these two concepts simultaneously.

Enter @bahnebahners.bsky.social 👇👇