Baptiste Lacoste

You know exactly what to do 💪🏻🫡

The best Sunday of the year 🤩 #peaceful #fall

A privilege to chair symposium ‘Vascular function and cognitive health across the lifespan’ symposium today at @ecnp.eu
Thanks to speakers @vcoelhosantoslab.bsky.social Amanda Kiliaan, @mariangelesmoro.bsky.social and @blacoste.bsky.social for their fantastic presentations.
#ECNP2025

Yes I am here lol 😇

Soluble guanylyl cyclase, the NO receptor, drives vasorelaxation via endothelial S-nitrosation | PNAS We previously demonstrated that the NO-stimulated soluble guanylyl cyclase (GC1), which produces cGMP, also has the ability to transfer S-nitrosoth...

An important advance in vascular biology!! #endothelium #vascular

Thanks again Yao Yao for the kind invite to USF! Super fun visit, I learned a lot from you and your colleagues 🙏🙏

Volumetric Analysis of the Blood–Brain Barrier After Ischemic Stroke by Electron Tomography in Mice Objective Transmission electron microscopy (TEM) enables ultrastructural investigation of both organic and nonorganic samples. However, conventional TEM is limited by the acquisition of two-dimensio...

Interested in assessing #BBB integrity at high resolution in 3D by electron tomography without spending $$$$$ on cryo-EM? I think we can help with this detailed method 😇 #cerebrovascular #microscopy #EM

Good question but that remains to be tested 😇

Very proud to have Bernard’s team in our Program!

Acetaminophen, not acedow-manophin

I would prefer “may not be” or “do not seem to be” 😇

Freedom of speech on X, not on Jimmy Kimmel

Very cool new paper from @caglaeroglu.bsky.social's lab showing the mitochondria dynamics regulate astroglial morphogenesis! doi.org/10.1083/jcb.... #Astrocytes #Development

FOXQ1 Regulates Brain Endothelial Mitochondrial Function by Orchestrating Calcium Signaling and Cristae Morphology FOXQ1 emerges as a master transcriptional regulator of brain endothelial metabolism, orchestrating mitochondrial function through dual control of calcium signaling and cristae organization. This stud...

New work establishing a key role for FOXQ1 in the regulation of brain endothelial metabolism. #Cerebrovascular

CXCR3-CXCL11 signaling restricts angiogenesis and promotes pericyte recruitment Endothelial cell (EC)-pericyte interactions are known to remodel in response to hemodynamic forces, yet there is a lack of mechanistic understanding of the signaling pathways that underlie these event...

#Pericyte #Endothelium #Angiogenesis

Reviewing vascular influences on neuronal migration, cortical development, and neurodevelopmental disorders: focus on autism, ADHD and schizophrenia - Molecular Psychiatry Molecular Psychiatry - Reviewing vascular influences on neuronal migration, cortical development, and neurodevelopmental disorders: focus on autism, ADHD and schizophrenia

The type of stuff I like (not biased at all...) #Cerebrovascular #autism #Development

Cerebrovascular p16INK4A expression induces cerebral small vessel disease-related phenotypes - Acta Neuropathologica Communications Cerebral small vessel disease (cSVD) is the most common cause of vascular cognitive impairment and dementia (VCID) and highly associated with Alzheimer’s disease pathogenesis. There is an urgent need ...

#cerebrovascular #SmallVesselDisease

I hope he gets what he deserves

Génial!

Inhibition of proprotein convertase SKI-1 prevents blood vessel alteration after stroke - Nature Cardiovascular Research Shabanzadeh et al. identify and validate a pathway whereby RGMa cleavage by SKI-1 modifies gene expression related to blood–brain barrier (BBB) integrity after stroke. SKI-1 inhibition restores BBB in...

New paper by Philippe Monnier's team: Inhibition of proprotein convertase SKI-1 prevents blood vessel alteration after stroke @natureportfolio.nature.com #Stroke #BBB #cerebrovascular

Patience

Absolutely fascinating science and interactions with families here at the 2025 Synchrony Symposium on #autism in Monterey! A wonderful gathering organized by the Brain Foundation. #TranslationalScience

Celebrating all things is a healthy philosophy!

Thrilled to be listed as invited speaker for @harvardmed.bsky.social's Neurobiology seminar series in December! Please come if you are around 😊. I'll share the whole neurovascular story about neurodevelopmental disorders #ASD #cerebrovascular #seminar

#development #metabolism 👇👇

Impaired capillary–venous drainage contributes to gliosis and demyelination in mouse white matter during aging - Nature Neuroscience How reduced blood flow plays a role in progressive white matter loss during aging and associated cognitive decline is unclear. Here the authors show that selective constriction and rarefaction of capi...

Another beautiful study by the lab of @andyshihlab.bsky.social published today in @natureportfolio.nature.com 👏🏻👏🏻👏🏻 #cerebrovascular #aging

Non-invasive characterization of pericyte dysfunction in mouse brain using functional ultrasound localization microscopy - Nature Biomedical Engineering An optimized pipeline for functional ultrasound localization microscopy is safely and non-invasively applied to detect and characterize early microvascular alterations with high spatial and temporal r...

Really cool stuff on #pericytes @natureportfolio.nature.com !

It’s been a long while since I posted an #astrophotography image, but from my vacation in France I have access to clear and deep skies! Below is the heart of M16, and its famous “Pillars of Creation”.🤩

Congrats on a new amazing story!

Brain endothelial gap junction coupling enables rapid vasodilation propagation during neurovascular coupling Vasodilatory signals are rapidly communicated across long distances by endothelial-endothelial gap junctions, enabling coordinated dilation of the arterial network during neurovascular coupling.

Very cool new paper by @thegulab.bsky.social published in Cell, showing that arterial endothelial coupling via gap junctions determines the speed and spread of vasodilation induced by neuronal activity ! #cerebrovascular #bloodflow #endothelium