Haley Lab

📣Faculty Position Opening!

👩🏾‍🔬An exciting opportunity for an Assistant Professor position in aging research at @UMontreal

🗓️Application deadline 15 September

#FacultyJobs #CdnSci #Research #Aging

medicinoxy.com/assistant-pr...

Group Leader - Genome Biology Unit Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...

To all post-docs: The Genome Biology dept ‪@embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

last call!
submit your abstract by tonight to be selected for one of the many oral presentations at the leading European Transposon Meeting. We are very much looking forward to your contribution and attendance!

A novel, high-density CRISPR activation platform for mapping cancer dependencies and resistance pathways ex vivo and in vivo CRISPR activation (CRISPRa) enables precise, locus-specific upregulation of gene expression, offering potential for both ex vivo and in vivo applications. However, the lack of scalable, high-coverage ...

New preprint that we're super excited to share! With @ceo.onjcri.org.au and colleagues @wehi-research.bsky.social and @ONJCRI, along with teams @Genentech, we developed + demonstrate the use of Partita, a new suite of CRISPRa libraries for murine model systems.

www.biorxiv.org/content/10.1...

Systematic identification and characterization of eukaryotic and viral 2A peptide-bond-skipping sequences Rao et al. identified thousands of previously unknown 2A peptides across both viruses and eukaryotes using an HMMER analysis. The authors further identified a unique class of 2A peptides, class B, who...

Going deep on 2A peptides:

www.cell.com/cell-reports...

(Trying to pick between GSG:T2A, GSG:P2A, and furin site:GSG:T2A)

CRISPR researchers and startup entrepreneurs will share new building in UC Berkeley's Innovation Zone - Berkeley News A planned addition to the campus's Innovation Zone will expand lab space for the Innovative Genomics Institute and build out the largest innovation hub — Bakar Labs — at any U.S. university.

We’re thrilled to announce IGI–Bakar Labs. This new building will allow the IGI to continue expanding our impact in health and agricultural applications of #CRISPR, and will be shared with the Bakar Labs incubator for growing biotech companies. Learn more: news.berkeley.edu/2025/07/17/c...

Isoform-specific single-cell perturb-seq reveals distinct functions of alternative promoters in drug response https://www.biorxiv.org/content/10.1101/2025.07.14.664827v1

Excited to share our latest by my postdoc Ben KS: we use statistical physics & Bayesian inference to model genome-wide perturbation outcomes. Remarkably, perturbation responses are encoded in gene "chatter" even before the perturbation–a fundamental insight with broad implications
shorturl.at/2LHbw

Assistant Professor (Research), Gerald Bronfman Department of Oncology, Lady Davis Institute for Medical Research (C1-250514) Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...

Please RT! The oncology department & McGill is hiring an Assistant professor for a lab to be located at Lady Davis Institute (where I am!). McGill and the Lady Davis are fantastic places to do research and Montreal is great city to live in.

mcgill.wd3.myworkdayjobs.com/en-US/McGill...

Native, Spatiotemporal Profiling of the Global Human Regulome The regulome, comprising transcription factors, cofactors, chromatin remodelers, and other regulatory proteins, forms the core machinery by which cells interpret signals and execute gene expression pr...

Here we go, my first skeet-torial(?) on Bluesky for my first paper from @talusbio.bsky.social !

www.biorxiv.org/content/10.1...

This preprint describes our scalable, mass spec-based method for measuring which (and how many of them) proteins are interacting with DNA.

1/?

Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease - Nature Reviews Molecular Cell Biology Transposable elements (TEs) comprise nearly half of the human genome. This Review discusses transcriptional and post-transcriptional mechanisms that repress TE activity, how TEs escape this suppressio...

We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...

A CRISPR/Cas9 screen reveals proteins at the endosome-Golgi interface that modulate cellular anti-sense oligonucleotide activity - Nature Communications Antisense oligonucleotide (ASO) cellular activity requires endosomal escape. Here, the authors show that disrupting Golgi-endosome protein AP1M1 enhances ASO activity by prolonging ASO endosomal resid...

Now in @natcomms.nature.com‬! Our work on the molecular mechanisms of gymnosis & its relevance to ASO/oligo therapeutics. An amazing collaboration with F. Roudnicky, L. Malong, A. Spang & more. Thanks to the editor/reviewers for their thoughtful feedback. www.nature.com/articles/s41...

Broad's Machine Learning in Drug Discovery Symposium coming soon! Nov 7, 2025. Another great lineup.

In person (Cambridge MA) and online options

Register by July 4 for a discount

www.broadinstitute.org/machine-lear...

Here is the official posting for a faculty job in Pharmacology and Therapeutics at Roswell Park Comprehensive Cancer Center! Feel free to DM or email with questions.
roswellpark.wd5.myworkdayjobs.com/en-US/Ext-RP...

Acquired resistance in cancer: towards targeted therapeutic strategies - Nature Reviews Cancer Acquired therapeutic resistance is a key contributor to cancer treatment failure, requiring new approaches to address its complex mechanisms. In this Roadmap, Soragni, Knudsen and colleagues discuss t...

Acquired resistance limits the efficacy of cancer treatments & accounts for therapy failure in most patients. Our Roadmap explores how innovative technologies bridge the gap between fundamental research on resistance and clinical translation into actionable strategies
www.nature.com/articles/s41...

Principles and functional consequences of plasmid chromatinization in mammalian cells Plasmids have fundamentally transformed how we resolve regulatory grammar across the tree of life. However, although chromatin plays an integral role in regulating the function of regulatory elements ...

Cool stuff re: plasmid chromatinization from the Stergachis Lab (not on Bluesky?). As they note in the discussion, it would be interesting to apply this to other extra-chromosomal contexts like AAV and the ecDNA found in some tumor cells.

www.biorxiv.org/content/10.1...

@isabellease.bsky.social is drawing amazing artwork for each speaker at #VariantEffect25 - crazy beautiful and super good summaries in all cases, have a look🤯

One thousand candidate enhancers tested in vivo in the mouse brain! A massive resource and oh so useful as validation set for genome-wide enhancer prediction methods. Super fun to be involved in one of the papers: ‘the prediction challenge paper’ by Nelson&Niklas et al www.cell.com/cell-genomic...

Cool! And, potentially super useful for synbio applications!

Online now in Cancer Discovery for the #AACR25 session on Advances in #KRAS Biology in PDAC by session speaker Andrew Aguirre: Response and Resistance to RAS inhibition in Cancer doi.org/10.1158/2159...

Assistant Professor (Research), Department of Microbiology & Immunology, (C2-240724) Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...

Another McGill Assistant Professor job at the Lady Davis Institute (where I am)! This is for an immunology (host-virus interactions) position! Come by my colleague! mcgill.wd3.myworkdayjobs.com/en-US/McGill...

In @nature.com we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR enzymes, offering safer & more efficient genome editing tools 🧬🖥️ @rachelsilverstein9.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social
www.nature.com/articles/s41...

Transplanting dopamine-releasing neurons into the brain is a promising regenerative therapy for Parkinson’s disease shown safe in two clinical trials @nature.com
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Engineering innate immune cells for cancer immunotherapy - Nature Biotechnology The unique attributes of innate immune cells position them as attractive candidates for cancer immunotherapy, with engineering strategies to enhance their antitumor potential, offering notable therape...

Engineering innate immune cells for cancer immunotherapy go.nature.com/3E9NbjZ

Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity Robot-assisted analysis and theoretical modeling of TCR/CAR crosstalk enable the design of adoptive T cell therapies that maximize anti-tumor activity and minimize toxicity in healthy tissues.

'We used a high-throughput platform to systematically evaluate the impact of co-expressing a TCR and CAR on the same CAR T cell. While strong TCR-antigen interactions enhanced CAR activation, weak TCR-antigen interactions actively antagonized their activation'
#Immunology #Immunotherapy

Microbial warfare brought us CRISPR. What big breakthroughs could be next? Gene editing and many other useful biotechnology tools came from studies of bacteria fighting off viral invaders. But scientists have only begun to unlock the secrets of this ancient arms race.

OK. I don't need to explain the importance of 'blue-sky' research to people on here, but this story in @nature.com is so cool! The area of research that delivered CRISPR gene editing has exploded and is turning up all kinds of cool tools for molecular biology. www.nature.com/articles/d41...

Canada Excellence Research Chairs (CERC) - Montréal, Quebec (CA) job with University of Montreal (UdeM) | 12838461 Canada Excellence Research Chairs (CERC)

If you’re interested in moving your lab to beautiful Montreal Canada, this program offers chairholders funding of up to 1M$ a year for 8 years. See link for details.
www.nature.com/naturecareer...

We are seeking a new colleague to join us at the Vienna BioCenter, specifically at my beloved home institution, IMBA @imbavienna.bsky.social

we value collegiality and a passion for curiosity driven science. Being a great and fun human being also helps!

Assistant Professor (Research), Department of Anatomy and Cell Biology (C1-250306) Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...

Come by my colleague!! Assistant professor position in molecular neurobiology at @mcgill.ca and the Lady Davis Institute! mcgill.wd3.myworkdayjobs.com/McGill_Caree...

Montreal is an amazing city and the Lady Davis is a great institute to work at!

our work on the molecular differences between transcription factor isoforms is out now in Molecular Cell!

key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity

many are "negative regulators" & misexpressed in cancer

www.sciencedirect.com/science/arti...