D. Parker Kelley, PhD

𝗛𝗼𝘄 𝗱𝗼 𝗯𝗿𝗮𝗶𝗻 𝗮𝗿𝗲𝗮𝘀 𝗿𝗲𝗹𝗮𝘁𝗲𝗱 𝘁𝗼 𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻?
"High-resolution activity maps of PFC did NOT align with cytoarchitecturally defined subregions."
Key tenet in neuroscience is that cytoarchitectonic boundaries correspond to functional ones.
NB: study in the mouse
#neuroskyence
doi.org/10.1038/s415...

Please use full factorial designs in preclinical psychedelic research! I'm guilty of not doing so in the past, but it will be critical for understanding their MOA going forward. We need to be able to directly compare effects in pathology to those healthy organisms

Excellent interview... VERY interesting insights on stress vs mitochodrial energy balance. I wonder how much impact on stress adaptation can be gained by increasing mitochondrial resilience w keto/low carb/ Fasting and the right amount of Exercise stress (hiit, resistance trng)

YouTube video by Metabolic Mind Could Stress Be The Hidden Driver of Mental Illness?

I had a fantastic discussion about our Allostatic Triage Model of Psychopathology (ATP Model) and the potential mitochondrial and metabolic effects of psychedelics with @metabolicmind.bsky.social

Thanks so much for having me on!

Check er out:

youtu.be/-e49-DwCZ9A?...

Congrats @carmensandi10.bsky.social !!

Population norms. The average rate of neurodegenerative disease in the general population.

Posted the paper above

I posted the paper above

ADHD increases dementia risk, but the available epidemiological data suggests that stimulant medications may normalize risk. Totally fascinating

Thanks @hologramvin.bsky.social for this post! I did not know this so I hunted down the original paper:
jamanetwork.com/journals/jam...

Totally understandable and no worries at all. Thank you for the response. I’ll keep looking

Cool article. Not my field, so grain of salt, but regarding the cognitive benefits, I believe people need to take at least 5-10+ grams per day to significantly increase creatine concentrations in the brain, so you might not expect to see much change at the 3-5 grams/day recommended in the article.

Several others have now asked for references here too. Can you at least let us know where you heard this information so that I can try to track it down? I’m a scientist working partly in neurodegenerative diseases and I’m particularly curious about this question, and have been for some time

That’s really interesting. Do you have a reference for that study?

The neuron–astrocyte metabolic unit as a cornerstone of brain energy metabolism in health and disease - Nature Metabolism Bolaños and Magistretti illustrate how intercellular metabolic cooperation underpins brain function and provide examples of how disruption of the neuron–astrocyte metabolic unit contributes to disease...

Metabolism is an energetic circuitry that transcends cellular and organellar boundaries

www.nature.com/articles/s42...

Afaik, midazolam is not antidepressant, (but it does induce acute amnesia), begging the question initiated by @theborislab.bsky.social here: pmc.ncbi.nlm.nih.gov/articles/PMC... : are these expectancy effects? you tell someone something will work, they have a drug experience and then feel better?

There are at least 2 kinds of active placebos: phenomenological and therapeutic placebos.. do they trick the participant because they feel similar to the active drug or bc they produce therapeutic effects? I am not aware of the antidepressant properties of benzos, so I assumed it was phenom placebo

Wait so midazolam is an antidepressant? Wut?

Hot off the press!

So many thanks to all of my mentors & co-authors for making this possible: @martinpicardenergy.bsky.social @thethrivelab.bsky.social @trpr-ucsf.bsky.social @parkersingleton.bsky.social @curiouslykaty.bsky.social, Gabriel Sturm, Ellen R. Bradley, Thomas Neylan, and Joseph Francis

The way we feel and the psychiatric symptoms some of us end up experiencing could emerge from the way energy flows, or fails to flow smoothly, in mitochondria.

The ATP model (Allostatic Triage in Psychopathology) by Parker Kelley @sequencemyneuro.bsky.social

www.sciencedirect.com/science/arti...

Altogether, we propose that extreme or chronic stress dysregulates mitochondria, affect, and allostatic triage, impairing allostasis, and driving transdiagnostic pathological states that, over time, become entrenched or "canalized" into pathological transdiagnostic disease phenotypes.

We propose that metabolic stress drives allostatic triage to stress-responsive networks that ensure short-term survival, like the salience network, from other networks including the central executive network that supports executive and goal-oriented functions, driving psychiatric symptoms

What happens when the brain cannot generate enough energy to handle stress?

Stress is metabolically expensive & all biology depends on finite energy resources, especially the CNS, which is the most expensive tissue in the body and has limited access to metabolic resources.

In the ATP Model, we introduce a novel concept- Allostatic Triage: the stress-induced reallocation of CNS metabolic resources from expensive executive control networks that optimize long term outcomes to less expensive networks optimized for short-term survival, like the salience network

🚨Publication alert! 🚨

Why does stress drive psychopathology & transdiagnostic disease?

We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens.

www.sciencedirect.com/science/arti...

Pα+ Psychedelic Bulletin #207: Lykos Rebrands to Resilient; Pharma Pushes Back on Norway’s Ketamine Reimbursement Decision; AbbVie-Gilgamesh Deal Viewed as Validation - Psychedelic Alpha Lykos Therapeutics Rebrands to Resilient Pharmaceuticals • Pharma Pushes Back on Norway’s Off-Label Ketamine Decision • AbbVie–Gilgamesh Deal Viewed as Validation for Short-Acting Psychedelics •

Pα+ Psychedelic Bulletin #207

- Lykos Rebrands to Resilient

- Pharma Pushes Back on Norway’s Ketamine Reimbursement Decision

- AbbVie-Gilgamesh Deal Viewed as Validation

- Psilocybin Rescheduling Petition Heads to HHS

- Much, much more...

psychedelicalpha.com/news/p%ce%b1...

Is it really? There are lots of bad therapists, but they nonetheless abide by strict ethical codes. Bad things happen with human therapists for sure, but I’m not sure we’re at the point in which we can even trust an AI not to hallucinate wildly and encourage patients to destroy their lives

I'm near certain sLFOs are big for psychedelics.

Just delighted to see this out in the world !! This is the first installment of SYPRES -- our living meta-analysis + open data resource focused on psychedelics. Led by the incomparable @parkersingleton.bsky.social and @bsevchik.bsky.social. Check it out + and give us your feedback!!!