D. Parker Kelley, PhD

Pα+ Psychedelic Bulletin #207: Lykos Rebrands to Resilient; Pharma Pushes Back on Norway’s Ketamine Reimbursement Decision; AbbVie-Gilgamesh Deal Viewed as Validation - Psychedelic Alpha Lykos Therapeutics Rebrands to Resilient Pharmaceuticals • Pharma Pushes Back on Norway’s Off-Label Ketamine Decision • AbbVie–Gilgamesh Deal Viewed as Validation for Short-Acting Psychedelics •

Pα+ Psychedelic Bulletin #207

- Lykos Rebrands to Resilient

- Pharma Pushes Back on Norway’s Ketamine Reimbursement Decision

- AbbVie-Gilgamesh Deal Viewed as Validation

- Psilocybin Rescheduling Petition Heads to HHS

- Much, much more...

psychedelicalpha.com/news/p%ce%b1...

Is it really? There are lots of bad therapists, but they nonetheless abide by strict ethical codes. Bad things happen with human therapists for sure, but I’m not sure we’re at the point in which we can even trust an AI not to hallucinate wildly and encourage patients to destroy their lives

I'm near certain sLFOs are big for psychedelics.

Just delighted to see this out in the world !! This is the first installment of SYPRES -- our living meta-analysis + open data resource focused on psychedelics. Led by the incomparable @parkersingleton.bsky.social and @bsevchik.bsky.social. Check it out + and give us your feedback!!!

It is impossible to explain to civilians how it feels to finally, FINALLY, land a clearly within-payline NIH grant score and then have it go unfunded because of all this regime bullshit.

You all have my sympathies. Unfair doesn’t even begin to describe it.

SYPRES (Synthesis of Psychedelic Research Studies) logo

🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵
www.medrxiv.org/content/10.1...

Such a beautiful project! This is the exact sort of framework we need to advance progress going forward.

Dispatch: The Neurobiology of Psychedelics Gordon Research Conference — Circuitry, Consciousness, and Clinical Horizons (Part 2) - Psychedelic Alpha In this second Dispatch from the inaugural Neurobiology of Psychedelics Gordon Research Conference, Dr. Alaina Jaster recaps Days 2 through 4, highlighting cutting-edge research on neuroplasticity…

Dispatch: The Neurobiology of Psychedelics Gordon Research Conference — Circuitry, Consciousness, and Clinical Horizons (Part 2)

Reporting by @jasteralaina.bsky.social.

The entire Dispatch is now free to read.

psychedelicalpha.com/news/dispatc...

Since its founding in 2021 by myself and Zarmeen Zahid as Your Brain on Science, it's expanded into Psychedelic Brain Science, to encompass the larger goal of including all things psychedelic including research, policy and culture.

Now we’re expanding further to provide services! Check it out!

Stomach–brain coupling indexes a dimensional signature of mental health - Nature Mental Health Using a relatively large and diverse sample of mostly young adults, this study by Banellis, Rebollo and colleagues examines associations between regional stomach–brain coupling and mental health and i...

I’m elated to share our latest publication - out now in @natmentalhealth.nature.com! www.nature.com/articles/s44... - tour de force by @leahbanellis.bsky.social @brainandstomach.bsky.social and the rest of the VMP team!

Dispatch: The Neurobiology of Psychedelics Gordon Research Conference — Plasticity, Psychotherapy, and Perception (Part 1) - Psychedelic Alpha Here, we share Dr. Alaina Jaster’s observations from the inaugural Neurobiology of Psychedelics Gordon Research Conference, where leading scientists gathered to explore various realms of psychedelic…

Check out my keynote & Day 1 dispatch of #GRCPsychedelics 🧠 via @psychedelicalpha.bsky.social

psychedelicalpha.com/news/dispatc...

Had a blast at the first ever #GRCPsychedelics - thanks so much to Chairs @alexkwan.bsky.social @vyazovskiy.bsky.social & Vice Chairs @melissaherman.bsky.social @viditavaidya.bsky.social for bringing our community together 🫶

Per usual, I took no pics - but luckily Missy had it covered for me 😂

Attending the first psychedelic GRC organized by @alexkwan.bsky.social & @vyazovskiy.bsky.social was surreal. The internationally representative panels ensure we are collectively/efficiently advancing our understanding of psychedelics. Special thanks to
@mayoonthebrain.bsky.social for bringing me ❤️

Bring out the dancing lobsters 🦞🕺

#GRCPsychedelics

@sequencemyneuro.bsky.social
@fredbarrettphd.bsky.social
@tanner-anderson.bsky.social

Dinner at GRC Psychedelics

Everyone approves of the dinner to end the #GRCPsychedelics 🦞

@deffinger.bsky.social @jasteralaina.bsky.social @sequencemyneuro.bsky.social @veronicachelu.bsky.social and Erin Neyhart

#OrganelleWars

Obviously the mitochondria is the best organelle.

1 can leave cell, but stays
2 own genome
3 regulates nuclear gene expression
4 can kill whole cell
5 makes energy, distributes it to orchestrate cellular processes
6 controls whole organisms behavior
7 makes (sex, growth, stress, etc) steroids

Climbing with fellow scientists at Psychedelics GRC

Science together climb together - sneaked out with fellow #GRCPsychedelics attendees for a quick session 💪

Great panel this morning on the human and clinical studies of psychedelics -

my impression is we have come a long way in the last few years in terms of design and quantification #GRCPsychedelics

@sofiyahupalo.bsky.social @cllantz.bsky.social @sequencemyneuro.bsky.social @oliverk28.bsky.social @christineliu.art @matt-spec.bsky.social @svmahler.bsky.social @callimcflurry.bsky.social @torbenott.bsky.social @mikaelpalner.bsky.social @ramosneuro.bsky.social

🌈🧠 The Trip Between Bedside and Bench 🌈🧠
Join us at #SfN2025 for a deep dive into cross-species research in psychedelic neuroscience!

🧬 Posters, 🎤 panels, 🔑 keynotes, 🍸 cocktails, and 🥟 tasty apps await.

RSVP, explore speaker profiles, and help spread the word:
👉 hopkinspsychedelic.org/sfn2025

I had a great time at #GCRpsychedelics, discussing our data on the non-hallucinogenic derivative of LSD, alongside a stellar panel of researchers! Very grateful to @alexkwan.bsky.social
and @vladvysotsky.bsky.social for inviting me and putting together a very exciting program!

NIH funding opportunities panel at the psychedelics GRC conference.

Thank you #NIMH #NIDA and #BrainInitiative for an informal panel at the #GRCPsychedelics to answer questions regarding grant funding. 🙏

Poster session in full swing. Lots of exciting unpublished work. #GRCPsychedelics

Going to open an escape room where hippocampus researchers have to solve riddles without using space as an explanation for everything

Psilocybin-enhanced fear extinction linked to bidirectional modulation of cortical ensembles - Nature Neuroscience Rogers et al. show that psilocybin enhances fear extinction, suppresses fear neurons and recruits extinction neurons in the retrosplenial cortex in mice, providing evidence that its effects are linked...

Psilocybin only enhances fear extinction when its hippocampus-dependent (trace/context), and only in a sub-population of mice.

Anybody have an explanation? I’ve got ideas, but curious what other are thinking about this ?

www.nature.com/articles/s41...

This is from The Tonight Show with Johnny Carson aired on May 20th, 1977.

Carl Sagan says something very important, a strong message that didn't lose any validity since then.

GDF15 links adipose tissue lipolysis with anxiety - Nature Metabolism Anxiety-like behaviour in mice, as a result of psychological stress, is shown to be mediated by GDF15 release in response to adipose tissue lipolysis.

Wowzers, a peripheral mitokine,GDF-15 mediates anxiety behavior caused by restraint stress through the GFRAL receptor in the brain stem!

“Anxiety-like behaviour elicited by adrenaline or restraint stress is eliminated in mice lacking the GDF15 receptor GFRAL”

www.nature.com/articles/s42...

I was so proud to rock my Mitochondrial Psychobiology sweatshirt to this event and discuss the effects of psychedelics on systemic bioenergetics with everyone!

Sasha started this work while working as a chemist at Dow Chemical after developing the first biodegradable pesticide, but later left Dow and continued his work in this back yard laboratory.