Martin Picard

Nice, thank you for sharing this, Jordan.

Thank you!

ATTENTION: Mitochondria Psychobiology, Stress & Health Symposium - MitoWorld It’s time for a science of health, and a good look at the science behind the healing process. It looks likely that mitochondria play a central role in our ability to heal and be resilient. – Martin Pi...

More on the project and event here: mitoworld.org/attention-mi...

MiSBIE Study The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study is a NIH-funded research platform allowing investigators to ask deeply interdisciplinary questions around brain-body processes,....

Tomorrow is the 2025 MiSBIE Symposium!

Registration and zoom link here: picardlab.org/MiSBIE

Thanks to the >550 registered.
It should be fun.

Superb energy patterns emerge after an egg is fertilized

2025 MiSBIE Symposium
Mitochondrial Psychobiology, Stress, and Health

This Friday December 12
In person in NYC and on Zoom around the globe
Free registration: www.PicardLab.org/MiSBIE

Preliminary agenda:

Completely agree. And if I can make a self-promoting plug here, we have a nice table in this paper trying to separate some of these ideas out. The brain is very information-efficient (bits/ATP), while still being very expensive in energy consumption (ATP/sec).
www.sciencedirect.com/science/arti...

Metabolic states change behavior by altering biological structures. Energy transformation all the way.

When mitochondria came in, complexity was most likely already there, but mitochondria might have spurred sociality between cells, making multicellular life possible

www.cell.com/action/showP...

Oh so much more…

Love it! Position of the future.

Mitochondrial and psychosocial stress-related regulation of FGF21 in humans - Nature Metabolism FGF21 levels increase in response to acute mental stress in individuals with impaired mitochondrial OxPhos capacity, and correlate with stress-related neuroendocrine hormones and trait-level psychosocial factors.

RESEARCH | M Kurade, @martinpicardenergy.bsky.social et al (Columbia Univ)

FGF21 levels increase in response to acute mental stress and correlate with stress-related hormones. 🧪

ATTENTION: Mitochondria Psychobiology, Stress & Health Symposium - MitoWorld It’s time for a science of health, and a good look at the science behind the healing process. It looks likely that mitochondria play a central role in our ability to heal and be resilient. – Martin Pi...

Our interview with @martinpicardenergy.bsky.social on MitoWorld’s MitoBlog is live!

Martin tells us about MiSBIE, how it came about, what it is and who should attend the 2025 MiSBIE Symposium

mitoworld.org/attention-mi...

Good news for the world.

The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease - Nature Metabolism This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing and disease contributes to cognitive decline.

The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease www.nature.com/articles/s42...

How Does Stress Cause Gray Hair? Stress can accelerate the depletion of pigment-producing cell progenitors, which is a natural aging process. But this may be reversible to a certain extent.

Stress exposure can trigger hair/fur greying in mice, and also in humans. In humans, the graying process is at least temporarily reversible.

Like the rest of our psychobiology, the aging process is not a linear process. It is dynamic, energetic, and malleable.

www.the-scientist.com/how-does-str...

Yes, inspiring

Spectacular time of year

Wise Carl Sagan, thank you for sharing

“Look again at that dot. That's here. That's home. That's us. On it everyone you love, everyone you know, everyone you ever heard of, every human being who ever was, lived out their lives…. on a mote of dust suspended in a sunbeam.”

-the Pale Blue Dot by Carl Sagan ✨🌏

MiSBIE Study The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study is a NIH-funded research platform allowing investigators to ask deeply interdisciplinary questions around brain-body processes,....

Interested in energy-based thinking around health?
Interested in mitochondria and body-mind processes?

Join us for the 2025 Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) Symposium on December 12th.

Poster abstract submission open.

www.picardlab.org/misbie

The Energy Resistance Principle (ERP) is a quantitative framework that bridges physics and biology, revealing metabolism as the energetic circuitry through which electrons flow, from food to oxygen, to fuel our lives

@msahsorin.bsky.social

authors.elsevier.com/a/1luVK5WXUl...

Quite likely that abnormal cellular metabolism (excess energy resistance, éR) is a driver of inflammation and atherosclerosis

The neuron–astrocyte metabolic unit as a cornerstone of brain energy metabolism in health and disease - Nature Metabolism Bolaños and Magistretti illustrate how intercellular metabolic cooperation underpins brain function and provide examples of how disruption of the neuron–astrocyte metabolic unit contributes to disease...

Metabolism is an energetic circuitry that transcends cellular and organellar boundaries

www.nature.com/articles/s42...

Just leaving this right here....👀

Mitonuclear interactions and early-life diet shape adult nutritional behaviour Abstract. Mitochondrial function relies on close coordination between the mitochondrial and nuclear genomes. Disruption to this coordination—via mitonuclea

Hot of the press #mitochondria paper!! 🎉 @jevbio.bsky.social

New evidence that #mitonuclear discordance and early-life #diet jointly shape development and adult behaviour in #Drosophila. 🪰🦠🧬🍝
@fcamus.bsky.social @dk-dowling.bsky.social et al.,

academic.oup.com/jeb/advance-...

In this context, restricting their food increases lifespan. Is this due to “calorie restriction” extending lifespan in normally behaving animals, or because the control condition's overfeeding, stressed, and sedentary state shortens lifespan, which calorie restriction then simply mitigates?

When animals are confined in small cages with unlimited food and no need to forage, without mates, and sometimes in isolation, they are sedentary and overfed—we called this the "control" condition.

The fallacies from animal studies applied to humans extend beyond addiction and mental health, likely to calorie restriction and metabolic health.

In attempting to control every variable, we can distort context and conclusions.

Video of Johann Hari

"The most precious gift we can offer others is our presence" ⎸ Thich Nhat Hanh

When we are present and listen, we open up energetically to be moved by another person. We offer them something to resonate with.

It is among the most precious gifts.

Discussion with the brilliant Lily Mujica-Parodi.