Pierre-Marie Bertrand

📊 @jama.com study by @emilymoin.com shows how U.S. ICU care changed 2014–2023:
- Mortality ↑ during COVID, then returned to baseline
- Mechanical ventilation ↓ below prepandemic levels
- Vasopressor use tripled, remains high
ICU practices are shifting.
doi:10.1001/jama.2025.2163 #CriticalCare

Educational Strategies for Clinical Supervision of Artificial Intelligence Use | NEJM Many learners are more facile with the use of large language models in medicine than their supervisors are. The authors provide an approach to clinical supervision that can mitigate the perils and ...

🧠 In @nejm.org, Raja-Elie Abdulnour et al. warn: AI in medical training risks deskilling & mis-skilling. They propose DEFT-AI to teach critical thinking & safe human-AI collaboration. Verify, then trust.
📖 doi.org/10.1056/NEJM...
#ResearchEthics #MedicalEducation

🚨 New Publication Alert

“Chat-IRB? How Application‑Specific Language Models Can Enhance Research Ethics Review” — now available online ahead of print in the Journal of Medical Ethics (5 August 2025). jme.bmj.com/content/earl...

Chat-IRB? How application-specific language models can enhance research ethics review Institutional review boards (IRBs) play a crucial role in ensuring the ethical conduct of human subjects research, but face challenges including inconsistency, delays, and inefficiencies. We propose t...

🧠 Can AI support ethics committees without replacing them?
Porsdam Mann & @briandavidearp.bsky.social propose IRB-specific LLMs to streamline reviews, reduce delays, and assist—not replace—human judgment. A major step to ease the daily burden.
📖 doi.org/10.1136/jme-...
#ResearchEthics #AI #Bioethics

Is Suffering a Useless Concept? “Suffering” is a central concept within bioethics and often a crucial consideration in medical decision making. As used in practice, however, the concept risks being uninformative, ambiguous, or ev...

Is Suffering a Useless Concept? www.tandfonline.com/doi/full/10....

new RCT just came out on the management of acute necrotic collections (ANC) that may complicate necrotizing pancreatitis

ANCs are early sterile collections containing fluid and sometimes debris

they *lack* a well-defined wall (unlike pseudocysts or walled-off necrosis)...

🧵 #1/ #EMIMCC

The Social Value Misconception in Clinical Research Clinical researchers should help respect the autonomy and promote the well-being of prospective study participants by helping them make voluntary, informed decisions about enrollment. However, part...

🧪 In AJOB, Jake Earl et al. warn of a new ethical risk in clinical trials: the Social Value Misconception. Altruistic participants may falsely believe in exaggerated benefits for society—compromising consent and autonomy.
📖 doi.org/10.1080/1526...
#Bioethics #ResearchEthics

😷 In @atscommunity.bsky.social , Lautrette et al. find that ICU visitation restrictions during COVID-19 didn’t increased anxiety, depression, or PTSD in relatives. Key risk factors : Female, spouse, poor communication.
📖 www.atsjournals.org/doi/10.1164/...
#ICU #MentalHealth #COVID19

🧠 In @accpchest.bsky.social, Dr Tietbohl & Moss explore strategies to improve surrogate informed consent in ICU research: Dedicates Research Coordinator (over PI), timing, trust, and clarity matter most.
Time to standardize and fix consent!
📖 journal.chestnet.org/article/S001...
#ResearchEthics

Cardiac arrest from neurological causes: for whom the brain tolls Cardiac arrest of neurological cause (CA-NC) is an entity whose incidence is unknown. The main reason for this is that the medical literature is mainly concerned with cardiac arrest due to cardiac cau...

#Cardiacarrest from neurological causes: for whom the brain tolls - Resuscitation www.resuscitationjournal.com/article/S030... @resuscitation.bsky.social @stlegriel.bsky.social #marinepaul

Now published 🚨 When to create embryos or organoids for research | Journal of Medical Ethics jme.bmj.com/content/earl...

YouTube video by AP-HM - Hôpitaux Universitaires de Marseille Jérémi, infirmier en psychiatrie à la Conception - Un métier authentique, une équipe solide

On a besoin d’un petit coup de main 💬
On recrute des infirmier·ères en psychiatrie pour nos équipes à l’Hôpital de la Conception, à Marseille.
Un partage, un relais, un mot : ça peut vraiment aider.
Merci à celles et ceux qui feront passer le message 💙

Il commence a y avoir du monde… En tout cas bienvenue !

When to create embryos or organoids for research The development of brain organoids and use of human embryonic neural structures for research each raise distinct ethical considerations that require careful analysis. We propose that rather than attem...

🧠 In J Med Ethics, Sebastian Porsdam Mann & @briandavidearp.bsky.social argue that how we define moral status—by potential or current capacities—should guide the ethics of brain organoids and human embryonic neural tissue research.
📖 jme.bmj.com/content/earl...
#ResearchEthics #Bioethics

Rapid Recovery of Donor Hearts for Transplantation after Circulatory Death | NEJM We report a method for the recovery of hearts for transplantation from deceased donors after circulatory death that obviates the need for thoracoabdominal normothermic regional perfusion or ex situ...

🫀 Landmark innovation in #HeartTransplant: in today’s @nejm.org Williams et al. present REUP, a low-cost, ethically sound method to recover hearts after circulatory death—no ex situ device, no reanimation. Early results looks promising.
📖 doi.org/10.1056/NEJM...
#Graft #Transplantation

Assessing FilmArray Pneumonia+ panel dynamics during antibiotic treatment to predict clinical success in ICU patients with ventilated hospital-acquired pneumonia and ventilator-associated pneumonia: a... Background Accurate microbiological documentation seems central for managing severe pneumonia. While the FilmArray® Pneumonia + panel (FA-PP) offers rapid pathogen identification, its effectiveness du...

🦠 In ICU pneumonia, rapid PCR like FilmArray® helps diagnose—but can it predict outcomes?
Julien Dessajan et al. show that FA-PP tracks bacterial decline but fails to foresee clinical success.
Initial test: yes ✅
Repeat testing: not so fast 🚫
🔗 doi.org/10.1186/s130...
#IntensiveCare #VAP

Oncologists’ knowledge, practices and ethical opinions about therapeutic misconception: a French national survey - BMC Medical Ethics Background Therapeutic misconception (TM) among research participants refers to the conflation of research goals (generating generalisable knowledge) with clinical care goals (making the best decision...

🧪 In a national survey, @haaserthibaud.bsky.social et al. show 84% of oncologists face therapeutic misconception—yet many miss or even reinforce it. Ethics training changes that.
🙌 It’s time to act to strengthen consent and research integrity.
📖 doi.org/10.1186/s129...
#ResearchEthics

@drn4z.bsky.social: Maybe it’s worth a shot? Let’s bring it up with Philips next time we meet about ICCA!

A common longitudinal intensive care unit data format (CLIF) for critical illness research Critical illness threatens millions of lives annually. Electronic health record (EHR) data are a source of granular information that could generate crucial insights into the nature and optimal treatme...

👨‍💻We are still stuck with digital versions of paper charts!
Chute in @intenscaremed.bsky.social calls for normalized EHR data to unlock clinical insight such AI and interoperability.
We must rethink our EHRs—the future demands structured data.
🔗 pmc.ncbi.nlm.nih.gov/articles/PMC... #ResearchEthics”

Programme TV : « Au nom de la science, la recherche sur l’homme » sur LCP, le long chemin vers l’encadrement légal Anja Unger, retrace, depuis le procès de Nuremberg, la prise en compte progressive de l’éthique en matière d’expérimentations médicales sur l’humain, en France et aux Etats-Unis.

📺 "Au nom de la science, la recherche sur l'homme" : l'encadrement de la recherche médicale, du procès de Nuremberg aux lois actuelles. Scandales et prises de conscience font naître une éthique de la recherche.
👉 10/07 20h30 LCP : www.lemonde.fr/sciences/art...
#Consentement #ResearchEthics

Informed Consent Under Ignorance In recent years, an old challenge to informed consent has been rediscovered: the challenge of ignorance. Several authors argue that due to the presence of irreducible ignorance in certain treatment...

🧠 Can you truly give informed consent if you can’t grasp the outcome?
Daniel Villiger tackles the “ignorance challenge” and defends informed consent—even under deep uncertainty.
Autonomy & vulnerability…

🔗 doi.org/10.1080/1526...
#Bioethics #MedicalEthics #ResearchEthics

Reconstruction of patients' treatment preferences in disorders of consciousness: a systematic review - BMC Medical Ethics Background Patients with disorders of consciousness (DoC) are unable to partake in the decision making process concerning their treatment. In the process of medical decision-making, which in DoC often...

🗣 Niek Kok et al. explore how clinicians and families reconstruct treatment preferences for patients with disorders of consciousness. Three epistemic models—correspondence, coherence, and communitarian—frame this ethically charged practice.

🔗 doi.org/10.1186/s129...
#ResearchEthics #Bioethics

oral vanco prophylaxis in patients with recent Cdiff who need systemic antibiotics:

RCT with signals of efficacy (yet disappointing)

I will continue using oral vanc prophy for now

(should we be using *longer* vanc courses to prevent delayed Cdiff?)

jamanetwork.com/journals/jam... #IDsky #EMIMCC

Vulnerability in research ethics: A systematic review of policy guidelines and documents Background The history of research involving human subjects has demonstrated the importance of offering everyone an equal opportunity to participate in research, while safeguarding those who require s...

🧬 Just out in PLOS ONE: Asia Grigis et al. dissect how vulnerability is defined and managed across global research ethics policies. A call for clarity, a path to harmonisation — and a timely challenge for European ethics frameworks.
#ResearchEthics #ClinicalTrial

🔗 doi.org/10.1371/jour...

Adherence to post-cardiac arrest care guidelines and impact on survival and neurological outcome - Annals of Intensive Care Background Post-cardiac arrest (CA) care guidelines (GLs) have been introduced in 2010 and periodically updated every 5 years since then (in 2015 and 2021). However, the impact of these GLs on patient...

🚨 New in Annals of Intensive Care!

Giulia Merigo et al. show that adherence to post-cardiac arrest care guidelines improved over 14 years—but better adherence didn’t significantly boost survival or neuro outcomes.

🧠 Key? Haemodynamic optimization.

🔗 doi.org/10.1186/s136...

🧪 Ethics isn’t just paperwork — it’s the foundation of trust in biomedical research.
This new JAMA article from Siebert reminds us: everyone involved, from labs to journals, shares the duty to uphold ethical standards.
🔗 doi.org/10.1001/jama...
#ResearchEthics #ICMJE #Bioethics #OpenEthics

@euroneuro2025 in Paris great talk from Pr Lionel Naccache about how you understand conscience with epilepsia.

Le Monde has a livestream of the national philosophy exam 😆 commentator "can we say that these exam questions are difficult this year?" ; expert "no, they are perfectly doable". The breaking news is that RAWLS makes its first appearance in the history of the exam LETSGO

💧 Should fluid therapy in #ICU pts be shorter & more strategic?

🔹 Excessive fluid resuscitation=worse outcomes;
🔹#ROSE model & deresuscitation strategies aim to balance perfusion+ 💧 overload;
🔹Tools like US & bioimpedance can guide safe fluid removal

criticalcarescience.org/article/flui...