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@mingli-lab.bsky.social

4 Followers  |  17 Following  |  2 Posts  |  Joined: 21.11.2024  |  1.2741

Latest posts by mingli-lab.bsky.social on Bluesky

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Zang, DeSantis et al @umich.edu reveal CCSer2 as a Ndel1 binding protein that regulates #dynein activity at the cell periphery. Loss of CCSer2 disrupts #centrosome positioning & early #endosome trafficking, causing migration defects in developing #zebrafish & cell culture rupress.org/jcb/article/...

23.04.2025 15:56 โ€” ๐Ÿ‘ 6    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
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Come together, right now The chaos, conflicting information, firings, and hurtful rhetoric of the Trump administrationโ€™s approach to science over the past month are causing anxiety, grief, and concern for the scientific commu...

Come together, right now | Science www.science.org/doi/10.1126/...

26.02.2025 14:07 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

How do cells maintain lysosomal integrity under stress? In our latest review, we break down five levels of lysosomal quality controlโ€”regulation, reformation, repair, removal, and replacement. Summarized by our awesome postdoc, Danielle Henn.
doi.org/10.1080/1554...

25.02.2025 16:48 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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A multi-subunit autophagic capture complex facilitates degradation of ER stalled MHC-I in pancreatic cancer Pancreatic ductal adenocarcinoma (PDA) evades immune detection partly via autophagic capture and lysosomal degradation of major histocompatibility complex class I (MHC-I). Why MHC-I is susceptible to ...

In case you missed it.. New preprint! Our latest study identifying how MHC-I is captured by autophagy and targeted for degradation in #PDAC - It all happens at the ER ! Congrats to co-first authors Marine Berquez, Alex Li & Matthew Luy.
www.biorxiv.org/content/10.1...

12.12.2024 04:48 โ€” ๐Ÿ‘ 38    ๐Ÿ” 18    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

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