Franck Touret

Yes on suit ça de près aussi 😁

While not a replacement for standard antiviral screening, this 3D model offers valuable insights into viral replication, pathogenicity, and host-pathogen interactions.

Our research findings:
RVFV and PIRV replicated in the liver spheroids; AHFV and YFV did not.
Broad-spectrum antivirals (favipiravir, nitazoxanide, ribavirin, galidesivir) showed activity, though higher doses were often needed versus traditional 2D models.

Haemorrhagic fever viruses remain a major global health threat—highly lethal, with limited therapeutic options. In our recent study, we explored a 3D human liver spheroid model to evaluate its potential for antiviral assessment against 4 BSL-3 viruses: AHFV, YFV, PIRV, RVFV.

Just published in Antiviral research!
3D Liver Spheroids in the Fight Against Haemorrhagic Fever Viruses
t.co/FuxQ76acrg
@ird-fr.bsky.social @univ-amu.fr @insermpacacorse.bsky.social

On a des antiviraux efficaces: paxlovid ( Nirmatrelvir) et xocova ( ensitrelvir) on sait comment faire un vaccin ou des anticorps thérapeutiques rapidement.
On est entouré de virus à la capacité zoonotique et celui là se rajoute juste à la longue liste mais tkt a l UVE on est là pour ça 😉

Oui c’est uniquement l’entrée mais d’autre facteurs rentrent en ligne de compte pour un changement d’hôte et une zoonose( par exemple la capacité du virus à échapper à la réponse immune). De plus avec le recul un coronavirus est moins inquiétant que d’autres familles virales 1/2

Design and synthesis of novel thioether analogs as promising antiviral agents: in vitro activity against enteroviruses of interest. The Enterovirus genus contains two major subgroups: rhinovirus (RV) species A-C and enterovirus (EV) ones A-D. While RV only infects the respiratory s…

www.sciencedirect.com/science/arti...

Moreover, pharmacokinetic modeling suggests promising druggability for these compounds.

These results position OM1260 and HR-568 as strong candidates for further development, potentially paving the way for the first curative treatments for enteroviral infections.

Docking studies provided insights into their structure-activity relationships, while time-of-drug addition assays revealed that these inhibitors act early in the viral replication cycle.

This led to the discovery of two promising broad-spectrum inhibitors, OM1260 and HR-568.
Both inhibitors show micromolar activity against multiple enterovirus types (EV-A71, E30, and CVA24), with EC50 values ranging from 0.4 μM to 4.38 μM, depending on the virus strain and cell line.

Our consortium has made an exciting step forward in the fight against these viruses. After developing initial EV-A71 inhibitors, we optimized their structure through iterative chemical modifications to enhance their activity and broaden their spectrum.

Despite their significant impact, there are currently no commercial curative treatments available.

🔬 New Research Breakthrough: Broad-Spectrum Inhibitors for Enteroviruses🦠Enteroviruses (EV) are a diverse group of viruses that can cause a range of illnesses, from mild fever to severe neurological complications.

Assessing Human Liver Spheroids as a Model for Antiviral Drug Evaluation Against BSL-3 Haemorrhagic Fever viruses Haemorrhagic fever viruses (HFVs) cause highly lethal syndromes with limited therapeutic options. Increasingly, 3D cell culture models are becoming an important tool in the field of virology. Since th...

Read more about our findings in the preprint! 📖
www.biorxiv.org/content/10.1...

Our research underscores the growing importance of advanced 3D models in virology and drug development. This tool could help accelerate the identification of new therapies for HFVs and improve our understanding of their mechanisms.

While this model offers valuable insights, it’s not a replacement for standard selection steps in antiviral drug development but could play a key role in understanding viral pathogenicity and host-pathogen interactions.

Key findings :
RVFV and PIRV were able to replicate in the spheroids, while the orthoflaviviruses did not show replication.
Antiviral compounds like favipiravir, nitazoxanide, ribavirin, and galidesivir demonstrated activity, though higher doses were required in 3D models compared to 2D cultures.

Our latest study explores the use of a 96-well liver spheroid model composed of human primary cells to assess the antiviral activity of key compounds against four BSL-3 HFVs: Alkhumra haemorrhagic fever virus (AHFV), yellow fever virus (YFV), Pirital virus (PIRV), and Rift Valley fever virus (RVFV).

🚨 New Insights on Hemorrhagic Fever Viruses & 3D Cell Culture Models 🦠
In the ongoing battle against hemorrhagic fever viruses (HFVs), the development of effective antiviral strategies remains a critical challenge.

From Rogue virologist

Epidemic Zika virus strains from the Asian lineage induce an attenuated fetal brain pathogenicity - Nature Communications During the 2015–2016 outbreak, Zika virus infection was linked to birth defects. Here, the authors show that epidemic strains cause less severe disease in mouse embryos than pre-epidemic strains and c...

www.nature.com/articles/s41...

The main paper of my PhD thesis

Due to the words limitation i will make it short but thanks to @franckdrtourte.bsky.social , Dr. Suzanne Kaptein, @neytsjohan.bsky.social, Christian Alfano, Carla Gomes da Silva, Ivan Gladwyn-ng, Emily Slowikowski and Prof Marques

🤚please

Merci

👋🏻

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C’est énorme! Faut faire une grosse fiesta!

C’est super cool de pouvoir tracer son histoire aussi loin!

Vous avez toujours été en Suisse ou vous avez bougé depuis ces 600 dernières années?

« Pas sérieux » c’est gentiment dit j’aurais été moins poli 😉