Andreas Aufschnaiter

My main PhD paper is finally out! 🎉

After ~5 years, it’s published today in 𝘕𝘢𝘵𝘶𝘳𝘦 𝘐𝘮𝘮𝘶𝘯𝘰𝘭𝘰𝘨𝘺.
@natimmunol.nature.com

It all started with an unexpected observation 🔍:
👉 Mice lacking the dendritic cell receptor DNGR-1 developed tumours earlier ⏩ and more frequently 📈 than wild-type mice.

1/11 🧵

🧪 thanks for sharing! here's the paper without paywall if anyone's interested: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

🧪 the landscape of cell death is online! Spent half a year in Seattle, WA in @drewoberst.bsky.social `s lab, where we came up with a new way to conceptualize cell death commitment, similar to Waddington's famous landscape of lineage commitment! Thanks TJ and Andrew! #celldeath (free access👇)

WHERE ARE ALL THE DARK PROTEINS? There are thousands of unconventional open reading frames (ORF) - stretches of code with specific three-letter-sequences - in the human genome that aren't expected to produce a protein, but seem to do so anyway. They can be upstream or downstream of a conventional gene, or they can overlap with it to varying degrees. Many are found within long non-coding RNAs, which weren't thought to encode proteins. Some of these peptides seem to regulate the activity of nearby genes, but for most, their purpose is unclear.

#Medsky🧪#microsky #immunosky Finding the “dark proteins” .There are thousands of unconventional open reading frames (ORF) - stretches of code with specific three-letter-sequences - in the human genome that aren't expected to produce a protein, but seem to do so anyway.

Mitochondria and cell death - Nature Cell Biology Several processes of regulated cell death engage or use mitochondria, which are thus central hubs that not only coordinate cell death but also elicit non-lethal signalling mediated by mitochondrial ou...

☕This year, in our #CellDeath focus:
Glover, Schreiner, Dewson & Tait reviewed the intersection of #mitochondria and cell death. #pyroptosis #ferroptosis #necroptosis #apoptosis
👉https://rdcu.be/d46gt
www.nature.com/articles/s41...

hello fellow whovian

agarose gel with a happy face

sadistic smile only to mock me before I found out the PCR didn't work 😂.. #scienceisfun