Jonathan Haars

At the 8th Nordic Conference of Antiviral Treatments Strategies and Drug Resistance at the beautiful Norrlands Nation in Uppsala, arranged by my co-supervisor Johan Lennerstrand 🧪 #Science #Antivirals #HIV #SARSCoV2 #Hepatitis #Virology

At the 8th Nordic Conference of Antiviral Treatments Strategies and Drug Resistance at the beautiful Norrlands Nation in Uppsala, arranged by my co-supervisor Johan Lennerstrand 🧪 #Science #Antivirals #HIV #SARSCoV2 #Hepatitis #Virology

Mutation Patterns Threaten Monoclonal Antibody Utility The following is a summary of “Dynamics of SARS-CoV-2 variants and mutations in Central Sweden between 2023 and 2024 and their potential implications on monoclonal antibodies pemivibart and sipavibart...

A summary of our recent study on SARS-CoV-2 and monoclonal antibodies was published in Physician's Weekly 🧪 www.physiciansweekly.com/mutation-pat...
#COVID19
#SARSCoV2
#Science

Dynamics of SARS-CoV-2 variants and mutations in Central Sweden between 2023 and 2024 and their potential implications on monoclonal antibodies pemivibart and sipavibart as PrEP in the region Monoclonal antibodies (mAbs) are an important option against SARS-CoV-2, especially as pre-exposure prophylaxis (PrEP) for patients with immune system impairment. PrEP mAbs like sipavibart and pemi...

Link to the original research article: www.tandfonline.com/doi/full/10.... 🧪

Mutation Patterns Threaten Monoclonal Antibody Utility The following is a summary of “Dynamics of SARS-CoV-2 variants and mutations in Central Sweden between 2023 and 2024 and their potential implications on monoclonal antibodies pemivibart and sipavibart...

A summary of our recent study on SARS-CoV-2 and monoclonal antibodies was published in Physician's Weekly 🧪 www.physiciansweekly.com/mutation-pat...
#COVID19
#SARSCoV2
#Science

Nationwide multicentre study of Nanopore long-read sequencing for 16S rRNA-species identification - European Journal of Clinical Microbiology & Infectious Diseases Purpose Recent improvements in Nanopore sequencing chemistry has made it a promising platform for long-read 16S rRNA sequencing. This study evaluated its clinical utility in a nationwide collaboration...

A Genomic Medicine Sweden project that our lab was part of has been published, 16S sequencing using #nanopore #sequencing 🧪 link.springer.com/article/10.1...

#Science #Research #Microbiology

Frontiers | Comprehensive transcriptome assessment in PBMCs of post-COVID patients at a median follow-up of 28 months after a mild COVID infection reveals upregulation of JAK/STAT signaling and a prol... BackgroundPost-acute sequelae of SARS-CoV-2 infection (PASC), also known as post-COVID-19 condition (here abbreviated as post-COVID) is an escalating global ...

Comprehensive transcriptome assessment in PBMCs of post-COVID patients at a median follow-up of 28 months after a mild COVID infection reveals upregulation of JAK/STAT signaling and a prolonged immune response

🧪
#COVID19
#SARSCoV2
#PostCovid
#LongCovid
#PASC

doi.org/10.3389/fimm...

Dynamics of SARS-CoV-2 variants and mutations in Central Sweden between 2023 and 2024 and their potential implications on monoclonal antibodies pemivibart and sipavibart as PrEP in the region Monoclonal antibodies (mAbs) are an important option against SARS-CoV-2, especially as pre-exposure prophylaxis (PrEP) for patients with immune system impairment. PrEP mAbs like sipavibart and pemi...

Happy to share our latest scientific article, “Dynamics of SARS-CoV-2 variants and mutations in Central Sweden between 2023 and 2024 and their potential implications on monoclonal antibodies pemivibart and sipavibart as PrEP in the region”
#COVID19
#SARSCoV2
www.tandfonline.com/doi/full/10....
🧵1
🧪

Frontiers | Comprehensive transcriptome assessment in PBMCs of post-COVID patients at a median follow-up of 28 months after a mild COVID infection reveals upregulation of JAK/STAT signaling and a prol... BackgroundPost-acute sequelae of SARS-CoV-2 infection (PASC), also known as post-COVID-19 condition (here abbreviated as post-COVID) is an escalating global ...

Comprehensive transcriptome assessment in PBMCs of post-COVID patients at a median follow-up of 28 months after a mild COVID infection reveals upregulation of JAK/STAT signaling and a prolonged immune response

🧪
#COVID19
#SARSCoV2
#PostCovid
#LongCovid
#PASC

doi.org/10.3389/fimm...

Karin Elfving, Anna-Karin Jonsson and Hong Yin from @RegionDalarna, Patrik Ellström, Johan Lindh and René Kaden from the Department of Medical Sciences at Uppsala University and Uppsala University Hospital.
🧵10/10

The manuscript was written together with my co-supervisor Johan Lennerstrand and co-authors Navaneethan Palanisamy from Chester Medical School, Frans Wallin, Paula Mölling and Martin Sundqvist from Örebro University, and…
🧵9

The threat to global health by SARS-CoV-2, Covid-19 and long covid is not over. Continual surveillance through sequencing is needed to understand the dynamics of its spread and evolution.
🧵8

This highlights the importance of rapidly developing, testing and approving new drugs for viruses undergoing relatively rapid evolution, such as SARS-CoV-2 because of its large global spread.
🧵7

We found that the lineages and mutations causing resistance became more common during the study period. Meaning these monoclonal antibodies may be less useful than initially thought.
🧵6

Among these drugs are the monoclonal antibodies. Which are very important to some of the most vulnerable people in society, the immunocompromised. We investigated how common the SARS-COV-2 lineages and mutations which offer resistance were in central Sweden in 2023 and 2024
🧵5

Whole genome sequencing allows tracking mutations and how their abundance changes over time. These are important, they are responsible for how the virus spreads, for how the virus evades the immune system, and are also responsible for causing resistance against drugs.
🧵4

This has helped us track which variants of the virus are present in the population at different times. Waves of different variants come and go, spreading from one continent to the next.
🧵3

In a collaboration between Region Uppsala, Region Dalarna and Region Örebro we nanopore sequenced SARS-CoV-2 to track resistance mutations affecting monoclonal antibodies pemivibart and sipavibart #COVID19 treatments.
🧵2

Dynamics of SARS-CoV-2 variants and mutations in Central Sweden between 2023 and 2024 and their potential implications on monoclonal antibodies pemivibart and sipavibart as PrEP in the region Monoclonal antibodies (mAbs) are an important option against SARS-CoV-2, especially as pre-exposure prophylaxis (PrEP) for patients with immune system impairment. PrEP mAbs like sipavibart and pemi...

Happy to share our latest scientific article, “Dynamics of SARS-CoV-2 variants and mutations in Central Sweden between 2023 and 2024 and their potential implications on monoclonal antibodies pemivibart and sipavibart as PrEP in the region”
#COVID19
#SARSCoV2
www.tandfonline.com/doi/full/10....
🧵1
🧪

Incredible how quickly Yunlong Cao & co provide us w/info on the latest emerging SARS-CoV-2 variants.

Already, we have great data on BA.3.2 (the divergent saltation lineage detected in South Africa & the Netherlands & NB.1.8.1, an emerging contender for global dominance. 1/9

Tracking #SARSCoV2 lineage NB.1.8.1 - Globally

4/n

Nationwide multicentre study of Nanopore long-read sequencing for 16S rRNA-species identification - European Journal of Clinical Microbiology & Infectious Diseases Purpose Recent improvements in Nanopore sequencing chemistry has made it a promising platform for long-read 16S rRNA sequencing. This study evaluated its clinical utility in a nationwide collaboration...

A Genomic Medicine Sweden project that our lab was part of has been published, 16S sequencing using #nanopore #sequencing 🧪 link.springer.com/article/10.1...

#Science #Research #Microbiology

www.researchsquare.com/article/rs-5... 🧪

Evaluation of nationwide analysis surveillance for methicillin-resistant Staphylococcus aureus within Genomic Medicine Sweden Background. National epidemiological investigations of microbial infections greatly benefit from the increased information gained by whole-genome sequencing (WGS) in combination with standardized appr...

www.microbiologyresearch.org/content/jour... 🧪

No evidence for Peto’s paradox in terrestrial vertebrates | PNAS Larger, longer-lived species are expected to have a higher cancer prevalence compared to smaller, shorter-lived species owing to the greater number...

Peto's Paradox—that cancer does not increase with body size of mammals—was wrong.
A new, comprehensive study of 263 species documents higher cancer prevalence with increasing body mass. Some large animals (e.g. elephants) have some built-in genetic adaptations
www.pnas.org/doi/10.1073/... @pnas.org

This is the updated metagenomics protocol for respiratory samples

search.app/V491AEp3tmB7...

New #preprint from our #research group, Campylobacter jejuni isolated from wild birds and free-range poultry were whole-genome sequenced: papers.ssrn.com/sol3/papers....

#WGS #Science #Bacteria 🧪

At Stockholm University, we are now starting a 2-year Master’s programme in Evolutionary Genomics!

Topics include population genetics, phylogenetics, molecular & genome evolution, DNA sequencing, bioinformatics, and palaeogenetics.

Please spread the word!

www.su.se/english/sear...

Tis the season for #holiday lights. #avianinfluenza sequencing up and running on our new #mk1d from ⁦‪Oxford Nanopore at ⁦‪Pasteur Cambodia‬⁩ . #nanopore #oxfordnanopre #genomic #h5n1 #alliwantforchristmas #anywhereanything #virosky #idsky 🧪🦠🧬🔬🥼🥼🧑‍🔬

Very excited (and a bit nervous) to announce that I will be hiring two Postdocs for my new group(!) in Copenhagen to study the Neanderthal and Denisovan DNA which survives in present-day humans. Retweet will be much appreciated :)

Link for application:
candidate.hr-manager.net/ApplicationI...