Susanne Fleig

A non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis Folate metabolism is intricately linked to purine de novo synthesis through the incorporation of folate-derived one-carbon units into the purine scaffold. By investigating chemical and genetic depende...

New in @science.org 🧬

What if an enzyme you thought you knew turned out to control metabolism in a completely new way?

We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.

www.science.org/doi/10.1126/...

❣️New in @JExpMed

Proud to have contributed to the work of Cornelia Halin’s lab @ETH_en !

Single-cell & 3D imaging reveal unexpected diversity of human afferent lymphatic vessels including unique CD24⁺ valve LECs and key differences from mouse skin.

rupress.org/jem/article/...

Good coffee, good science!

would the original star wars movies count?
„a long time ago in a galaxy far, far away….“ - not spoken though, written intro.

Is it time to retire confirmatory testing for primary aldosteronism? Abstract. Primary aldosteronism(PA) is the most common endocrine hypertension. For decades, PA diagnosis has required proving non-suppressibility of aldost

academic.oup.com/ajh/advance-...

Long-Term Mortality After Renal Artery Stenting in Patients With Severe Atherosclerotic Renal Artery Stenosis and High-Risk Clinical Manifestations AbstractBACKGROUND. Atherosclerotic renal artery stenosis is a risk factor for cardiovascular death. Observational studies support the benefit of renal rev

#WeekendReads

Long term mortality after Renal Artery Stenting

🔗 academic.oup.com/ajh/article/... 🔓

#EditorsChoice #Free

Kidney dysfunction was diagnosed at 5-months postpartum in 12% of patients who had gestational diabetes mellitus. Read more in #ASNCJASN kidney.pub/CJASN0802

New in #ASNJASN and at #Hypertension25: In a randomized, double-blind, placebo-controlled trial, Baxdrostat reduced systolic blood pressure in patients with CKD and uncontrolled hypertension. Read more about its safety and efficacy in patients with CKD here: kidney.pub/JASN0849

If you are a nephrology or kidney disease or renal professional or interested in the field - make sure you have liked/followed/pinned the nephrology feed

bsky.app/profile/did:...

Thanks again to @richardferro.xyz for creating & updating this! It’s a one-stop shop for nephrology needs

#NephSky

Should you, too, feel like your brain is shrinking during the winter: here is why! 👇
(now, how closely related are we really to shrews!)

Now open access in @ndt-era.bsky.social

Anti-nephrin, anti-podocin and anti-Kirrel1 antibodies: Biological challenges and clinical implications

🧐 Clinical implementation of anti-slit diaphragm antibody testing = precision dx and tx in podocytopathies

▶️ academic.oup.com/ndt/article/...

Spread the word: The European Center for Angioscience @uniheidelberg.bsky.social continues to grow: We have openings for 2 additional Junior Group Leader positions. Get in touch with us if you are ready to start your own lab. See also corresponding ad in @nature.com: www.nature.com/naturecareer...

Wihuri Research Institute Symposium 2025 - Wihuri Research Institute Since 2013, the Wihuri Research Institute (WRI) has been organizing the annual WRI Symposium, providing a platform for researchers and students to share knowledge and insights in cardiovascular resear...

Exciting days ahead at the Wihuri Research Institute @wrihelsinki.bsky.social as we host #WRISymposium and #EVBOSummerSchool next week in Helsinki.

Looking forward to inspiring talks and scientific exchange with the #VascularBiology community!

wri.fi/research-act...
evbo.org/index.php/ev...

We also congratulate Dr. Laetitia Préau from Karlsruhe Institute of Technology (KIT) and Dr.Tore Bleckwehl from Uniklinik RWTH Aachen for their outstanding presentations

@cpi-exstra.bsky.social @sfb1531.bsky.social @sfleig.bsky.social

#PCVB2025

🔬 Congrats to the 2025 #GfMVB Award Winners! 🏆

Proudly #sponsored by ibidi at “Perspectives in Cardiovascular Biology” Conference🫀

🏅Emerging Scientist: Dr. Haaglim Cho from
@mpi-hlr.bsky.social

🏅Young Investigator: Dr. Julian Wagner from Universitätsmedizin Frankfurt

🔗https://zurl.co/IAJmC

Resolution of steatohepatitis without worsening of fibrosis occurred in 62.9% in the semaglutide group & in 34.3% in the placebo group.
Reduction in liver fibrosis without worsening of steatohepatitis was reported in 36.8% in the semaglutide group & in 22.4% in the placebo group
tinyurl.com/338u24b2

YouTube video by MARKUS at HOMe Vasopressin-Mangel (ehemalig Diabetes Insipidus) - Prof. Dr. Mirjam Christ-Crain (Basel, Schweiz)

Our Friday-Webinar with @christ-crain.bsky.social !

We talk about diagnosis and treatment of arginine vasopressin deficiency with our expert in german language!

youtu.be/jSl5K0aRTvs?...

B cell-derived exosomal miR-483-5p and its potential role in promoting kidney function loss in IgA nephropathy

doi.org/10.1016/j.kint.2025.03.019

#OpenAccess #MedSky #NephSky #SkyNeph #IgAN #IgAnephropathy

Academic Europe - Full Professorship for Nephrology

Job - Alert 🚑

🩺 Full Professorship for Nephrology

Deadline: 2025-05-03

Location: Switzerland, Bern

www.academiceurope.com/job/?id=7332

#hiring #Nephrology #medicine #biomedicine #Leadership #professor #director

Congrats to Maria Dekrolia, Nivethitha Manickam, Leah Vanicek, and Sofia de la Puente Secades for receiving the Aletta Jacobs Award at the PCVB Meeting 2025 in Frankfurt! A well-deserved recognition of their outstanding contributions to science. #PCVB2025 #AlettaJacobsAward

Tore Bleckwehl from Aachen presenting as a finalist in the GfMVB Emerging Scientist Award session at #PCVB2025 in Frankfurt!

Excited to share the most recent work from our lab and results from two exciting cooperations:

In this week's issue of @bloodjournal.bsky.social (ashpublications.org/blood/issue), Afra Anjum presents her cover story on how aging platelets gain inflammatory functions in the circulation. 1/4

A graph showing the least-squares mean percent change in the lipoprotein(a) concentration from baseline through 540 days in the efficacy analysis set, which included data from participants who received at least one dose of lepodisiran or placebo, with the exclusion of data collected from participants after discontinuation of lepodisiran or placebo or initiation of medications known to affect lipoprotein(a).

Presented at #ACC25:

Lepodisiran, an extended-duration, small interfering RNA, reduced lipoprotein(a) concentrations in participants with elevated levels. Full ALPACA trial results: nej.md/4kWjJyn

#MedSky @accintouch.bsky.social

During inflammation, CCL21 is down-regulated in the lymph node. Enzymes for production of oxysterols are induced and recruitment of naive/central memory cells relies more in oxysterols interacting with GPR183 (+ CCL19). in 🐭

Chen et al @cellpress.bsky.social 2025
pubmed.ncbi.nlm.nih.gov/39708807/

Finally!

(Psst it was never the fluid, it was always the sodium)

Cardiovascular, Kidney & Mortality Outcomes With Long-Acting Injectable & Oral GLP1-RA in T2 Diabetes

An updated meta-analysis of >70,000 patients after the SOUL trial

⬇️ 14% MACE
⬇️ 14% heart failure
⬇️ 17% CKD progression
⬇️ 12% all-cause mortality

diabetesjournals.org/care/article...

Insulin regulates lymphatic endothelial integrity via palmitoylation Lipid metabolism plays a critical role in lymphatic endothelial cell (LEC) development and vessel maintenance. Altered lipid metabolism is associated …

Our latest publication investigating the role of #palmitoylation in #lymphatic endothelial integrity.

Big shoutout to Silvia Gonzalez-Nieves, Simon GUIGNARD and Thi Nguyen for their incredible work and dedication. 👏👏

www.sciencedirect.com/science/arti...

A bit slow on the draw, but our manuscript phenotyping multiple sclerosis patients before and after anti-CD20 treatment is out in JCI! Using scRNAseq we show that there is a myeloid expansion in both blood and CSF. In blood there's a ubiquitous TNF-NFkB signature and monocytes make more TNF post-Tx

Effect of albumin treatment duration on response rates and outcomes in patients with cirrhosis and acute kidney injury Guidelines recommended volume expansion with albumin for 48 hours for patients with cirrhosis and acute kidney injury (AKI) to correct hypovolemia and…

Effect of albumin treatment duration on response rates and outcomes in patients with cirrhosis and acute kidney injury
#nephsky
www.sciencedirect.com/science/arti...

🆕 🥇FDA approved therapy for C3 Glomerulopathy
Iptacopan : inhibitor of the alternative complement pathway by specifically binding to and inhibiting factor B
#Hope for #kidney #disease
#Great time to be in #Nephrology
#Nephsky #Nephbluesky #Medsky #Medbluesky #Nephronuggets