Petrova Lab – Vascular and Tumor Biology

🎉 The full GRS and GRC Lymphatics 2026 programs are now online!

Amazing lineup of speakers and science. 🧬✨

www.grc.org/lymphatics-g...
www.grc.org/lymphatics-c...

🎉 Huge congrats to Dr. Anna Köck on her successful PhD defense!
She uncovered a new protein complex that limits nutrient uptake by the endothelial barrier with implications for metabolism, obesity, and drug delivery. 🔥
One paper accepted, another coming soon: stay tuned! 🌟

Special thanks to the clinical team of Thibaud Koessler at HUG
🙏 And our deepest gratitude to all patients who made this work possible.

This was an interdisciplinary effort with teams led by:
• @nzamboni.bsky.social ETHZ
• Simone Becattini (University of Geneva)
• L Francisco Lorenzo-Martin and Matthias Lutolf EPFL
• Caroline Pot CHUV
• Ting Hai Collet HUG
• Nicolas Vannini (Uni Fribourg)
• Deborah Stroka @dbmr-unibe.bsky.social

🦀 In patients with cancer, IPA levels are generally low, but increase in a subset after chemotherapy.
‼️ Higher IPA levels anticorrelate with monocyte abundance, a feature linked to poor prognosis.

🦠 Chemo‑induced gut injury expands bacteria that produce indole‑3‑propionic acid (IPA).
🦴 IPA reaches the bone marrow, normalizes myelopoiesis, and reduces immunosuppressive monocytes.
🛡️ This boosts T‑cell anti‑tumor activity and creates a metastasis‑refractory state.

Our new study is out! 🎉
Driven by MD‑PhD Ludivine Bersier, our work shows how chemotherapy‑induced gut injury creates a systemic “chemomemory” that protects against colorectal cancer (CRC) liver metastasis.
🔗 doi.org/10.1038/s414...
🧵 Thread 👇

Correct link:
form.jotform.com/LERN/2026-gr...

PhD students & postdocs working on lymphatic vessels - this is your chance!

🌍 Apply for the Travel Scholarship to the GRC on Lymphatics 2026 in beautiful Lucca, Italy.

Deadline: Dec 8. Don’t miss it!
form.jotform.com/LERN/2026-grc-

❣️New in @JExpMed

Proud to have contributed to the work of Cornelia Halin’s lab @ETH_en !

Single-cell & 3D imaging reveal unexpected diversity of human afferent lymphatic vessels including unique CD24⁺ valve LECs and key differences from mouse skin.

rupress.org/jem/article/...

‼️Lymphatic Education&Research Network-GRC Scholarships‼️

LE&RN is awarding 10 × $1,000 scholarships to early investigators to attend 2026 Lymphatics GRC March 1 – March 6, 2026, Lucca (Barga), Italy.

🗓 Apply by Dec 8, 2025!

form.jotform.com/LERN/2026-gr...

Well done Anna Köck - congrats on the best poster prize at the SSMVR Annual Meeting! 👏
And Linh Tran (Proulx Lab) for best talk! 🏆

Degeneration and Impaired Resilience of Skull Bone and Hematopoietic Bone Marrow Bone marrow health is central to transplantations, blood formation, and cancer progression. However, the bone marrow niche deteriorates with age, impairing haematopoietic stem cell function. Contrary ...

A recent preprint (Yang et al., doi.org/10.1101/2025...) challenges an article from my lab published in 2024 (Koh et al. 2024, PMID: 39537918). We strongly dispute their claims (please see our comment on bioRXiv).

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📣Registration is now open for the Gordon Research Seminar and Gordon Research Conference on Lymphatics 2026!

Half of the talks will be selected from submitted abstracts. Don’t miss your chance to share your work!
grc.org/lymphatics-g...
grc.org/lymphatics-c...