Gopalan

Many controversial column takes in the office this week… 🧪🤔

#chemsky how do YOU arrange your column test tubes?

This is a better summary than anything I've seen in mainstream or alternative media. Essential reading.

"Kids might die, but Robert Kennedy can keep cashing in," Sen. Elizabeth Warren says during a heated exchange with #RFK Jr. over whether he would agree to not taking fees from suing drug companies.

US funding freeze memo rescinded, NIH confusion persists Acting NIH director Memoli clarifies communication restrictions as White House moves to freeze US government grants

Literally every time I have filed this story (4x this week), something happened to change it before my editor had a chance to look.

But here’s WTF happened at NIH this week (so far)

cen.acs.org/policy/US-fu...

MS protein analysis—I’m one of many to follow in his footsteps. Great NIH program officers are the backbone of the extramural system. I owe much to several of them over the years.

RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow - Nature Nature - RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow

Just because a paper is highly cited, it doesn’t mean it is correct or truthful. This paper (www.nature.com/articles/nat...) was cited 4504 times and yet it was retracted.

There is no penalty for non-compliance. It’s just that someone someday will probably report it to the editors. 1/2

Mark, with all due respect. Sit down and visit with some folks who are intimately familiar with the NIH, the scientific process, how grants are handled and funded.

The NIH is not a business. There are no shareholders. There is no mandate for profit. This is not a business model and should not be.

I fear there is deep truth here.

Skimming through the latest paper journals plays a catalytic role in a fascinating decades-long friendship that Roald Hoffmann had with two Chinese chemists, Tang Ao-Qing and Lu Jiaxi. I recommend watching his recounting of a story of geopolitics and chemistry: www.sciencehistory.org/visit/events...

Us: "Hey we wrote a spirited defense of basic science funding, showing how it drives startup creation and ultimately GDP. Would you like to publish it as an OpEd?"

Major Media Outlets: "No."

Your regular reminder that you can cite unrefereed editorials, reviews, data, news, websites, books, even tweets. Citing preprints isn’t doing anything controversial 1/2

This is what happens when you let computer scientists design molecules 🤯 Oral presentation @neuripsconf.bsky.social #NeurIPS2024 #chemsky

The applying of immuno-RCA for the high-sensitivity detection of the ABO blood group antibodies on the printed glycoarray https://www.biorxiv.org/content/10.1101/2024.12.11.625986v1

Beautiful work - I love the analysis of organelle rearrangement in response to changes in lipid flux.

i do find it interesting in a bleak way that silicon valley is basically recapitulating 1920s-style american reactionary politics.

The journey of breakthrough medical treatments is long and tortuous. Loved hearing about the pioneering work of Pieter Cullis and the development of lipid nanoparticles!

Note on his slide “basic research is important”!

The critique isn't the failure to develop drugs. It's the pattern: Launch big claims, ignore evidence they don't work, move to new claims while maintaining certainty about old ones. Rinse, repeat.

PPI Prediction Challenge #2 For this protein-protein interaction prediction challenge, we present three target proteins: KRAS, RAF (the KRAS binding domain), and Mdm2. For each target protein, we are providing you a list of 8 po...

Back by popular demand, I present PPI Prediction Challenge #2.

My claim: I AM SKEPTICAL COMPUTATIONAL APPROACHES CAN PREDICT WHETHER TWO PROTEINS INTERACT.

Someone prove me wrong (take two).
docs.google.com/forms/d/e/1F...

1/n

a man in a suit and tie is saying " boom easy as that " Alt: a man in a suit and tie is saying “boom easy as that”

It reminds me to point out that Pauling’s PhD Thesis (PDF linked at the bottom of this page: thesis.library.caltech.edu/1791/) is literally a cover page followed by reprints of 5 JACS papers…

Yet another amazing and captivating story by @jeremymberg.bsky.social ⬇️🧵 ++ great (I agree) advice,

Prof Pauling, how do you come up with so many good ideas?

"I try to come up with many ideas and I throw away the bad ones" LC Pauling 👍🏻😎

I remain impressed that this got published in a high-profile journal. Most med chemists have a visceral, well-founded negative reaction to those structures. I wish we could teach our bio colleagues the structural spidey sense. Tip of the iceberg here when it comes to setting the record straight.

Do They Even Bind?

That awkward moment when someone publishes a paper saying that they can’t find any evidence that your compounds bind to what your own series of papers say that they bind to. . .

a little girl is sitting in a car seat holding a lollipop ALT: a little girl is sitting in a car seat holding a lollipop

I think I have not developed a thick skin of academia, yet. Manuscript getting desk rejected stings and it is not a great feeling to be in. Ugh!

Parallel measurement of transcriptomes and proteomes from same single cells using nanodroplet splitting - Nature Communications Single-cell multiomics can provide broad insights into gene/protein regulatory networks and cellular diversity. Here, authors develop nanoSPLITS, a nanodroplet splitting approach for global profiling ...

Now this is a paper I had long been waiting for! NanoSPLITS is out! Parallel single cell proteomic and transcriptomic measurements from the same cell! Great work from @cajunscience.bsky.social and @nanopots.bsky.social

www.nature.com/articles/s41...

You'll notice proteomics has tighter CVs and higher correlation between the cells. Also the average proteome to transcriptome correlation is low (~0.35). Really nice to see this quantified clearly

Using the word "Kickass" in the presentation of the official Nobel Lecture (Gary Ruvkun) 🤣

Still time to register to awsome Glycobiology Gordon Research Conference 2025. We have a fantastic line of speakers and this will be top #glycotime in Tuscany !! Register at www.grc.org/glycobiology...

you have seriously fucked it morally if people are posting like this ON LINKEDIN after you pass