There’s no reason to teach laypeople about every sequelae of metabolic syndrome. Most of these diseases, and MASH in particular, are just fructose toxicity. Teach people to stop eating added sugar and you won’t need to teach them any of these diseases.

The energy trajectory of AI data centers is more favorable than this. Training is very intensive but can be done offline during off peak and can utilize heat recapture. Inference has low latency reqs, but distillation is making it more energy efficient

Not entirely accurate; French uniforms in WWI, pantalon rouge, were meant to be flashy and to support the local dye industry. They were immensely impractical and got loads of Frenchmen killed in 1914

Wait, how many desktop items did you have?

Google search returns responses in microseconds and costs a trillionth of a penny for retrieval. GenAI takes several seconds and costs likely ten cents per query. Including them would be like including librarians in search engine market share

I read it more cynically: cath labs are very good at harvesting reimbursable procedures, even though it doesn’t change outcomes relative to medical management. That’s a challenge for insurance coverage

Interesting that the risk of MACE3 was reduced but the risk of revascularization was not (significant). You can cure cardiac issues, but you’re still gonna get stented.

Very curious to see the impacts on endometriosis. Needs more attention as is

These GLP1RA cohorts are kind of nonsense, as they combine less effective drugs in the class (Trulicity, Victoza) with far more effective new drugs (Ozempic, Mounjaro).

Need to integrate with nutrition and fitness. Ensure adequate protein intake and moderate resistance training.

Brenzavvy (bexagliflozin) costs $38 a month - stop prescribing insanely overpriced meds in the same class!

Totally agree. Seems like a classic case of increase sensitivity of diagnosis not increased underlying signal.

Does this say that more wore diagnosed with malnutrition with a dietician consult than without?

85 in June isn’t that hot…

Medicare or commercial plan?

Can I ask how difficult it was to get Zepbound covered with OSA diagnosis? Just need a sleep study or a lot of PA back and forth?

#Brenzavvy can be very helpful on affordability

Do you bake with zero calorie sweeteners or just bite the bullet with sugar? I’m also in the market for tips on which 0c sweeteners hold up better in baking

Boy are you gonna freak out when you learn the rest of US history

Who cares? Other than needing to be right on the internet; who cares?

That’s the wrong position; worse, it’s a losing position.

The legal definition of a refugee is largely at the discretion of the executive branch, as demonstrated by the recent revocation of that status for the groups you reference. True liberals, not rank partisans, support a broad definition of the term, not only when it applies to their preferred groups

I cannot imagine what good it can do to gatekeep who is and who is not a refugee. If someone wishes to leave their home for a better life, we should support that choice. It’s easier to defend the concept of inclusivity than to decide which groups are persecuted and which are not

It’s an interesting difference between British parliamentary politics and US politics - usually the opposition has a shadow cabinet to provide co tasting views, but the US nominating process means there is no defined leader of the opposition party

Increasingly difficult to justify keeping semaglutide in the formulary for anything close to the price of tirzepatide. A 50% discount seems like the minimum

Tirzepatide as Compared with Semaglutide for the Treatment of Obesity | NEJM Tirzepatide and semaglutide are highly effective medications for obesity management. The efficacy and safety of tirzepatide as compared with semaglutide in adults with obesity but without type 2 di...

SURMOUNT-5 Among participants with #obesity but without diabetes, treatment with tirzepatide was superior to treatment with semaglutide with respect to reduction in body weight and waist circumference at week 72 www.nejm.org/doi/full/10....

I would anticipate (maybe just hope) that semaglutide will become the cheaper maintenance option. Novo is already negotiating heavy discounts vs tirzepatide and they don’t have a great next gen candidate to compete with reta

Did they not record change in body weight?

Brenzavvy fixes this for SGLT2i class