Philipp Klein

This strengthens the recommendation for using unguided digital interventions in the treatment of depression.

(PDF) Effectiveness of unguided web-based interventions for the treatment of depressive symptoms in improving the quality of life: a meta-analysis PDF | Purpose Unguided internet-based interventions (IBIs) have proven to be effective in reducing depressive symptoms. The primary objective of this... | Find, read and cite all the research you need...

Thank you for the opportunity to contribute to this project!

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A recent meta-analysis by Felix Butt from Stephan Köhler`s research group at Charité, Berlin, suggests that unguided digital interventions have effects both quality of life might and on depression (g = 0.29 / 0.37).

Many researchers as well as clinicians and their patients would argue that an evidence-based intervention should show effects both on symptoms and on functional outcomes to receive a strong recommendation for use.

It is well-established that unguided digital interventions are effective in reducing symptoms of depression. But what about the effect on quality of life?

Causal inference interest group, supported by the Centre for Longitudinal Studies Seminar series 20th October 2025, 3pm BST (UTC+1) "Making rigorous causal inference more mainstream" Julia Rohrer, Leipzig University Sign up to attend at tinyurl.com/CIIG-JuliaRohrer

Happy to announce that I'll give a talk on how we can make rigorous causal inference more mainstream 📈

You can sign up for the Zoom link here: tinyurl.com/CIIG-JuliaRo...

Digging somewhat deeper: Judea Pearl, the pioneer of modern causal inference: youtu.be/MNyI1Xkapxg?...

And about to inaugurate a new head of state this coming weekend, I just learned

@mayer-l.bsky.social

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Congratulations, Lynn, on putting this together with such unwavering attention to detail! It has been a great pleasure working on this with you. And thank you wholeheartedly to Arnoud Arntz without whom this project would have been impossible!

She highlights that the advantages of the BPD-CL include the fact that it measures all symptom domains considered necessary for the diagnosis of BPD in the Diagnostic and Statistical Manual of the American Psychiatric Association (DSM).

That is the result of a study just published by Lynn Mayer in the International Journal of Methods in Psychiatric Research.

The Borderline Personality Disorder Checklist (BPD-CL) can be used for self-assessment in various languages because it is a reliable and valid measure of symptoms of BPD in its Dutch, English, German, Greek, Italian and Spanish version.

A great thanks to @toshi-frkw.bsky.social and @dingdingpeng.the100.ci for nudging me in the direction of modern causal inference methods.

Quite possibly one of the best presentations on how to conduct research. It is by Peter WG Tennant from the University of Leeds, UK and focusses on modern causal inference methods.

More on it here: youtube.com/playlist?lis...

Slide titled "Types of validity" Violence in video games affects aggression in youths. A affects B in C. This statement is a generalization, of which any part could potentially be invalid. Formalization of types of validity according to Estlinger et al., 2025

Slide titled: Overview validity A influences B in C Internal Validity: A influences B, rather than just being correlated with it. Construct validity (of the manipulation/treatment/cause): It is indeed A that has the effect, and not something else. Construct validity (of the effect, the outcome): It is indeed B that is being influenced External validity: The effect indeed occurs in C.

Getting ready to teach internal/external/construct validity, for the first time using the framing by Estlinger, @davebrady72.bsky.social and @eschwitz.bsky.social (www.degruyterbrill.com/document/doi...).

Super happy because this is much clearer than what I told student before!

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Congratulations, Katharina, on publishing this excellent study and thank you for letting me accompany you on this exciting scientific journey :-)

That is likely due to the fact that, thankfully, QTc prolongation due to psychotropics is rare and a much larger trial would be needed to demonstrate the clinical effect of pharmacist support.

They found that medical staff indeed enjoy the pharmacists support; and this support also enhances adherence to guidelines for monitoring QTc intervals. But it did not have an effect on clinical outcomes including changes in QTc time.

But does this also lead to better outcomes? That is the question addressed by Katharina Wien from Stefan Borgwardt's research group at Lübeck University.

Wouldn't it be wonderful if a pharmacist looked over your shoulder while prescribing psychotropics and made sure you are doing everything right to prevent your patient from prolonged QTc intervals and its consequences like life-threatening cardiac arrhythmias?

Yes, the data are available from
the corresponding author. And thank you for your interest in this paper :-)

Treatment expectations and depressive symptoms in an internet-based intervention for depression. A secondary analysis | Request PDF Request PDF | On Aug 1, 2025, Gwendolyn Wälchli and others published Treatment expectations and depressive symptoms in an internet-based intervention for depression. A secondary analysis | Find, read ...

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I am grateful for the opportunity to contribute to this work!

They conclude that treatment expectations might be a therapeutic process that can be utilized to enhance treatment outcomes.

This notion is supported by a recent study published by Thomas Berger's group from Bern, Switzerland. In a paper authored by Gwendolyn Wälchli they find that expectations developing during the course of therapy predict outcome but not expectations prior to the onset of therapy.

It has often been suggested that psychotherapy works because patients expect it will work before they have even started treatment. But what if treatment expectations are an emergent phenomenon that develops in the course of psychotherapy and contributes to a successful outcome?

If confirmed in randomized trials, enhancing the acquisition of skills taught in both BA and MCT could lead to greater treatment effectiveness.