Nathan Roach

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From the people who brought you the angry man “Angron” and the leader of the Iron Hands being named Ferrus Mannus.

🧬Explore the latest from Bioinformatics Advances: “Ish: SIMD and GPU accelerated local and semi-global alignment as a CLI filtering tool.”  

Read the full paper here: https://doi.org/10.1093/bioadv/vbaf292

Author: @ducktapeprogrammer.bsky.social

Apparently there’s a never ending stream of folks who think the issue with phrenology was the accuracy of the calipers.

Hire Nur!!

sigh

I really hate the term "sideloading". I preferred the original term, which was "installing software on a computer that you own"

God I wish that were me.

The view from a sand dune in great sand dunes national park. A long sand stretch in the foreground, and a mountain and the sky in the background.

A selfie with two people in front, and a stone palace behind, the cliff palace at Mesa verde National park.

A sunrise over the desert of canyonlands national park. A mesa is in the middle of the rising sun.

The view from the top of a rock in canyonlands national park. Rocks and mesas dotted with sparse foliage.

Been doing some traveling

The Meselson and Stahl experiment demonstrated in 1958 that DNA replicated semi-conservatively.

Meaning, each of the two strands of DNA serves as a template for a new copy to made of the complementary strand.

Foundational finding, elegant experimental design.

FWIW, I really appreciate that you have dedicated time to it. Your papers addressing it is important work, even if it shouldn’t have to be.

Soy facing at the concentration camp sign in my officially licensed concentration camp merch

Fascism looks a bit different in every country because it is a push towards return to an imagined past (and the past being imagined is different in different places), but the conspicuous consumption culture of the US and past of race segregation results in the most despicable people on earth.

This chart has been widely shared on here, it’s important to see the correction

centrists constantly complain about the left being insufficiently partisan and then line up behind a Democrat who handed the state Senate to Republicans and then gerrymandered the state to their benefit

This is a vital message: one of the larger reasons BlueSky is refreshingly free of alt-right shitlords is because in the early days we made a gentleperson’s agreement to starve these fuckos out and it worked. No likes, no quotes, no engagement. They got bored and left. Please keep the Old Ways.

Thanks to @michaelhobbes.bsky.social and Peter Shamshiri for this public service. This book has been widely celebrated by “very serious people“. The problem is that it is scientifically illiterate, and a clear case of motivated reasoning.

I'm trying to comment on this without being hyperbolic.

As a manager, insisting on deadlines that you and your ICs straight up don't believe are possible almost GUARANTEES that a) their work will be thrown out or completely redone and b) you will put them in danger of burning out.

ish is a grep-like CLI tool that uses optimal alignment instead of exact matching.

It’s record-type aware, supporting line, FASTA, and FASTQ records.

Built in Mojo as a proof of concept for bioinformatics.

🧵1/5

Abolishing ICE is now the compromise position. These evil dickheads need to be sent to The Hague

Are you looking for a faculty job? We are hiring in my department at Roswell Park NOW. Contact me for details as I await the formal ad. (Please RT.)

They're literally doing the meme

Unbelievably horrified by this attack in Boulder. We don’t know the full story of the attacker, but no matter what it is, let me be clear: Senseless, antisemitic attacks do not help Palestinians, Jews, or Israelis.

Committing terror attacks against people standing for hostages is disgusting.

Industry friends, now is the time for MUCH more speaking out on behalf of academic colleagues under duress. Here are core open source methods that many of your products doubtlessly depend on either directly or indirectly (see en.wikipedia.org/wiki/HMMER) being abruptly defunded. Make noise.

Partitioned Multi-MUM finding for scalable pangenomics Pangenome collections are growing to hundreds of high-quality genomes. This necessitates scalable methods for constructing pangenome alignments that can incorporate newly-sequenced assemblies. We prev...

Excited to share a new update to Mumemto, scaling MUM and conserved element finding to any size pangenome! Preprint out now w/ @benlangmead.bsky.social.
Mumemto scales to the new HPRC v2 release and beyond, and can merge in future assemblies without any recomputation! 1/n

A statue of a lamb, holding a flag and with its hoof while standing.

A statue of a lamb, laying down, with a flag held by its hooves.

I was just in Puerto Rico and really enjoyed these sheep conquistadors

Me in front of the finish line of the bolder Boulder, a local 10k

Did a thing