Anchel de Jaime-Soguero

‼️‼️📢📢 Job Alert!
Our lab at @iribhm.bsky.social - @ulbruxelles.bsky.social is seeking for a PhD student to work on the proteostasis of early mammalian development using stem cell models and the embryo. If you are enthusiastic about cell and dev biology, please apply!

Excited to present our work tomorrow online at Social DNAing series.

18.00PM CEST time following the link below.

The modularity of the mammalian #embryo in display. Controlled assembly of classic #gastruloids and uncommitted precursors in #hypoxia, patterns the AP axis
www.biorxiv.org/content/10.1...
Beautiful & insightful from @bulutkarslioglu.bsky.social‬ group. Building models to learn and learning.

New stem cell model sheds light on human amniotic sac development Researchers at the Francis Crick Institute have developed a new stem cell model of the mature human amniotic sac, which replicates development of the tissues supporting the embryo from two to four wee...

Crick researchers have developed a new stem cell model of the mature amniotic sac development.

The team is now exploring the potential for using these new 3D models in clinical applications, such as cornea reconstruction and treating ulcers.

www.crick.ac.uk/news/2025-05...

Join us tomorrow for our next seminar:

🗓️ Thursday, May 08
⏰ 9:30 PDT / 12:30 EDT / 16:30 UTC / 17:30 BST / 18:30 CET

Looking forward to giving this talk next week!

Aneuploidy is the leading cause of pregnancy loss. In work led by @saracarioscia.bsky.social and @aabiddanda.bsky.social, we reanalyzed genetic testing data from 139,416 IVF embryos to discover variants associated with recombination phenotypes and aneuploidy risk. www.medrxiv.org/content/10.1...

A new step has already begun. Happy to form part of @ulbruxelles.bsky.social and @iribhm.bsky.social community, and very much looking forward to developing my independent research lines on development and stem cell biology.

@acebronsp.bsky.social thanks for being such inspiring mentor, for caring for your people and for sharing your vast knowledge and experience. Your commitment to make us improve at the personal and professional level has been pivotal. It has been a great ride!

I arrived to Sergio Acebrón lab in July 2019, and I have truly enjoyed Heidelberg vibrant environment since then. Great colleagues, tons of fun, research and also (sometimes) desperation, but a group caring for eachother overall. It made so easy to progress and develop my scientific ideas.

Last few months have been of change. I finished my postdoc at @cosheidelberg.bsky.social and moved to Belgium to begin my research group at @iribhm.bsky.social. I will reflect here my thoughts about the last years experience.

Figure 1 Schematics of extra-embryonic mesoderm development across species. (A) An intermediate stage of reptilian development displaying the vascularized trilaminar omphalopleure, also known as choriovitelline membrane, and the bilaminar omphalopleure. (B) A later developmental stage in squamates, showing a feature unique to squamates: the yolk cleft. The composition of the amnion, allantois and chorion is similar in all reptiles. (C) E1 (24 h) chick embryo showing the primitive streak, area vitellina and vasculosa. (D) E10 chick embryo displaying the localization of vascularized and non-vascularized extra-embryonic mesoderm (EXM) cells.

In this Review, @eliananehme.bsky.social, @amiteshp.bsky.social, Isabelle Migeotte and @pasquelab.bsky.social give an overview of the embryonic origin and function of extra-embryonic mesoderm in vertebrates from in vivo studies.
journals.biologists.com/dev/article/...

Congrats Kristina! Really happy for you!!!

Do you want to illuminate your studies on innate immune responses? Our new biosensor monitors mtDNA from apoptosis, viral infections, other sources of dsDNA and environmental cGAMP. We also show that micro nuclei are poor activators of the #STING response

SAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026.
 
Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute).

www.embl.org/about/info/c...

Design of a STING fluorescent real time biosensor. Tour de force of my colleague #Steve under Sergio @acebronsp.bsky.social supervision. 👏👏👏

BMP signaling promotes zebrafish heart regeneration via alleviation of replication stress - Nature Communications Zebrafish show robust heart regeneration after injury. Here they show that zebrafish cardiomyocytes experience replication stress, which BMP signaling alleviates via a conserved mechanism of replicati...

Novel insights on cellular signaling regulation of DNA replicative dynamics.

BMP signaling not only prevents from replicative stress in pluripotency, as we described recently (www.nature.com/articles/s41...) but also drives regeneration through same mechanisms.

www.nature.com/articles/s41...

Surprisingly we find that as few as 2 starting p53KO cells will compete in an environment of @300 WT cells. Also, see an input for BMP & Wnt signalling that mirrors work on the control of chromosomal segregation in stem cells www.nature.com/articles/s41...

Great work on cell competition during mammalian gastrulation. It aligns with our observations on chromosome stability-driven by morphogens and open further questions on the relation of cellular fitness and genome integrity. Congrats!

Great city, great environment and cool projects (including stem cell modelling, development, homeostasis and cancer biology).

Have a look to the research groups offer and do not hesitate to apply!

Great opportunity for a PhD in Brussels. Outstanding mentor and project addressing bottlenecks in human development

The idol, the legend. Here first page of my PhD thesis.

⚠️📢 Few weeks to close the call. If you love cell & devbio, and are interested on doing a PhD in stress resilisence, please APPLY!

Anchel de Jaime Soguero: "Aragón necesita dar un impulso a la investigación básica" Tras pasar por Alemania, el biomédico aragonés lidera su propio grupo en el Instituto Interdisciplinar de Biología Humana y Molecular, en Bruselas.

Gracias a Pilar Perla y @heraldo.es por la difusión de nuestro trabajo en el lab de Sergio Acebrón @acebronsp.bsky.social y mi opinión sobre la investigación básica en mi tierra, Aragón.

www.heraldo.es/noticias/ara...

Registration is open for the 12th Advances in Stem Cell Biology Course #ASCBcourse at the @pasteur.fr
Hands-on training in different models, embryonic stem cells, iPS cells and much more on #StemCells.
🕘June23-July04, 2025
👉https://qrfy.io/VEcoKQpGfV

🚨 🚨 Job Alert!
I am currently opening my research lab at @iribhm.bsky.social @ulbruxelles.bsky.social in Belgium and I am seeking for an enthusiastic PhD candiate to study cellular stress across mammalian development and lineage specification! If you are interested, info below. Please RT!

Applications open for a new cohort of @dev-journal.bsky.social *Pathway to Independence* fellows

Know a #devbio post-doc about to enter the academic job market?

Would they benefit from a little support & mentoring?

Spread the word

Deadline 31 Jan 2025

journals.biologists.com/dev/pages/pi...

What a day! An honour to present our work next to these giants and the dynamic belgian stem cell researchers. Great to be back!

It was a fantastic edition of the 8th Meeting of the Belgian Society for Stem Cell Research in Brussels with stellar speakers including Susana de Sousa Lopes, Jacob Hanna, Florian Merkle, Anchel de Jaime-Soguero and many more. Thank you to all participants. #BeSSCR #StemCells

Doctoral Fellow – Cellular and developmental biology Unravelling developmental resilience towards cellular stress in development and lineage specification

If you are wishing to start your PhD, are excited about embryo development and cellular function and would like to work in an international environment at the heart of Europe, do not hesitate and apply!

More info: euraxess.ec.europa.eu/jobs/294110