Single-dose psilocybin rapidly and sustainably relieves allodynia and anxiodepressive-like behaviors in mouse models of chronic pain - Nature Neuroscience Hammo et al. show that a single dose of psilocybin rapidly and sustainably relieves both chronic pain and anxiodepressive-like behaviors in mice by restoring prefrontal activity through partial agonism at 5-HT2A and 5-HT1A receptors.

New paper in Nature Neuro, with very impressive results (in mice):
Single-dose psilocybin rapidly and sustainably relieves allodynia and anxiodepressive-like behaviors in mouse models of chronic pain
www.nature.com/articles/s41...

09.10.2025 10:01 — 👍 10    🔁 2    💬 0    📌 1

Some psychedelic medicine developers want to ditch the therapy aspect. What could go wrong? Are drugs like psilocybin and MDMA still safe and effective in the absence of psychotherapy?

Considering the phase 2 LSD for anxiety study has been published and is in the news a bit right now, here's a piece from last year where I spoke to the CMO of MindMed about the trial's somewhat unique protocol. Bit more detail here about how the dose sessions worked than in the actual study.

07.09.2025 22:21 — 👍 6    🔁 2    💬 1    📌 0

Spontaneous glutamate release activates mGluR signaling to drive rapid antidepressant responses | PNAS Major depressive disorder affects millions worldwide, yet current treatments require prolonged administration. In contrast, ketamine produces rapid...

Neat- Spontaneous glutamate release activates mGluR signaling to drive rapid antidepressant responses www.pnas.org/doi/10.1073/...

10.09.2025 10:48 — 👍 0    🔁 0    💬 0    📌 0

Does #ketamine work via opioid system?

This controversial idea finds new support in a randomized trial, where the opioid blocker naltrexone impeded ketamine's #antidepressant and glutamatergic effects:
www.ncbi.nlm.nih.gov/pubmed/40707...

#depression #psychiatry #pmhnp

11.08.2025 12:02 — 👍 6    🔁 1    💬 1    📌 0

09.09.2025 19:46 — 👍 4    🔁 1    💬 1    📌 0

Serotonin and psilocybin activate 5-HT1B receptors to suppress cortical signaling through the claustrum - Nature Communications Our basic understanding of neuromodulation in the claustrum remains limited. Here Madden et al., identify a key mechanism by which serotonin and the psychedelic psilocybin modulate cortical signalling...

www.nature.com/articles/s41...

20.08.2025 16:40 — 👍 4    🔁 3    💬 0    📌 0

ScienceDirect.com | Science, health and medical journals, full text articles and books.

The emotional architecture of the psychedelic
brain: If you are interested in #psychedelics and #emotions, take a look at our new paper: authors.elsevier.com/sd/article/S.... With Flora Moujaes, @nathalierieser.bsky.social, Lydia Belinger, Marcus Herdener, & Zarmeen Zahid. Just published in TICS.

19.08.2025 07:27 — 👍 11    🔁 3    💬 0    📌 1

SYPRES (Synthesis of Psychedelic Research Studies) logo

🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵
www.medrxiv.org/content/10.1...

18.08.2025 13:17 — 👍 34    🔁 24    💬 1    📌 3