Eric Ceballos

Spatial organization of AQP4 channels in the human brain: links with perfusion, edema, and disease vulnerability https://www.biorxiv.org/content/10.64898/2026.02.18.706679v1

🚨Do we need a large, expensive MRI scanner to map whole-brain networks in the mouse? Not necessarily!

In our new preprint ▶️ tinyurl.com/3a2h4r9f
we show that transcranial functional ultrasound (fUSI) can map connectome-scale networks with striking agreement to fMRI
🧵👇

We're hiring! This is a unique opportunity to translate our understanding of neural computation - from circuit-level mechanisms to computational principles - into the human brain, through the establishment of cutting-edge human neural recording capabilities with collaborators in London and abroad.

We’re hiring a Group Leader!

Join us to lead a transformative initiative in human systems neuroscience.

Find out more and apply ⤵️

www.sainsburywellcome.org/content/curr...

Inter-individual variability of neurotransmitter receptor and transporter density in the human brain | doi.org/10.1007/s004...

How do neuroreceptor distributions vary across people?

Left: Pathways involved in brain energy metabolism. Energy metabolism refers to processes involved in energy production from nutrient molecules. Glucose is the main energy source in the brain under normal physiological conditions. Glucose entering brain cells can be utilized in three parallel pathways. It can be processed through glycolysis to produce 2 ATP and 2 pyruvate molecules (blue). Lactate dehydrogenases catalyze the interconversion of lactate and pyruvate (purple). Pyruvate is transported into mitochondria, where it enters the TCA cycle to generate high-energy electron carriers NADH and FADH2 (green), driving the complete oxidation of glucose through the mitochondrial electron transport chain (red). Glucose entering the brain can also enter the PPP. PPP is an anabolic pathway that uses glucose to produce 5-carbon sugars and NADPH, an essential co-factor used in nucleotide and lipid biosynthesis (yellow). Glucose can also be stored in the form of glycogen via glycogen synthase, a process mainly active in astrocytes. Right: Energy pathway maps. Colors show z-scored mean expression values across all genes in each pathway. ppp, pentose phosphate pathway; tca, tricarboxylic acid cycle; oxphos, oxidative phosphorylation; lactate, lactate metabolism and transport.

How are energy #metabolism pathways distributed across the #cortex? @alaindagher.bsky.social &co map five pathways in the human #brain, linking metabolic organization with brain structural & functional properties, as well as developmental dynamics @plosbiology.org 🧪 plos.io/4c1JVp8

Convergent transcriptomic and connectomic controllers of information integration and its anaesthetic breakdown across mammalian brains - Nature Human Behaviour Luppi et al. identify transcriptomic and connectomic controllers of information integration and its breakdown induced by anaesthesia in humans, macaques, marmosets and mice.

Luppi et al. identify transcriptomic and connectomic controllers of information integration and its breakdown induced by anaesthesia across species

netneurotools: a trainee-oriented approach to network neuroscience | doi.org/10.1101/2025...

Our lab’s internal toolkit for accomplishing everyday tasks in brain imaging ⤵️

BOLD signal changes can oppose oxygen metabolism across the human cortex, Nature Neuroscience

fMRI signals “up,” but neural metabolism might be going “down.”

In our @natneuro.nature.com paper, we demonstrate that about 40% of voxels with robust BOLD responses exhibit opposite oxygen metabolism, revealing two distinct hemodynamic modes.

rdcu.be/eUPO8
funds @erc.europa.eu
#neuroskyence 🧵:

It's happening! Canada launched two programs to recruit international researchers.

Canada Impact+ Research Chairs (1 million/yr for 8 yrs +)
Canada Impact+ Emerging Leaders.

I will do my best to facilitate the process for those interested. Hit me up.

www.canada.ca/en/impact-pl...

Cognitive cartography of mammalian brains using meta-analysis of AI experts The complexity of the brain is increasingly mirrored by the complexity of the neuroscientific literature, yet no individual mind can fully grasp the diversity of scales, methodologies and model organi...

🧠 Excited to share our latest preprint: Automated Brain Mapping with AI Experts!🤖

www.biorxiv.org/content/10.6...

Ever wanted to summarise the cognitive/systems neuroscience literature beyond MRI and PET? Ever wished we could do the same for macaque 🐒 and mouse 🐭 ? Read on! 🧵👇

The Transmitter’s Rising Stars of Neuroscience 2025 We recognize the outstanding achievements of 25 neuroscientists who stand to shape the field for years to come.

Truly honored to be recognized among @thetransmitter.bsky.social's Rising Stars of Neuroscience for 2025 next to trailblazers like @valeriejsydnor.bsky.social, @lindenmp.bsky.social, @elimuller.bsky.social & more!🌟🧠Check out everyone's full contributions at www.thetransmitter.org/early-career...

I am recruiting graduate students for the experimental side of my lab @mcgill.ca for admission in Fall 2026!
Get in touch if you're interested in how brain circuits implement distributed computation, including dopamine-based distributed RL and probabilistic representations.

Jaxley: differentiable simulation enables large-scale training of detailed biophysical models of neural dynamics - Nature Methods Jaxley is a versatile platform for biophysical modeling in neuroscience. It allows efficiently simulating large-scale biophysical models on CPUs, GPUs and TPUs. Model parameters can be optimized with ...

I am super happy to share that our project on training biophysical models with Jaxley is now published in Nature Methods: www.nature.com/articles/s41...

Preprint -
Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo.
www.biorxiv.org/content/10.1...

Our recent work on spin tests is now published in Imaging Neuroscience🎉

As always, the code to reproduce our results and figures is available on github: github.com/netneurolab/...

The effect of spherical projections on spin tests for brain maps | doi.org/10.1162/IMAG...

Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️

Integrating and interpreting brain maps | doi.org/10.1016/j.ti...

Imaging and recording technologies make it possible to map multiple biological features of the brain. How can these features be conceptually integrated into a coherent understanding of brain structure and function? ⤵️

Normative blood perfusion map on lateral and medial views of the inflated and 2D flat cortical surfaces (fsLR). Borders and areal names of the multi-modal Glasser parcellation are overlaid on the flat surface. The figure highlights the non-uniform distribution of perfusion scores across the cortex, with areas that have sharp gradient compared to their underlying perfusion score levels (e.g., LIPv and MT/MST).

How does cerebral #BloodPerfusion map onto micro-, meso- & macro-scale brain structure? @asafarahani.bsky.social @misicbata.bsky.social &co characterize blood perfusion in the #HumanBrain, revealing how it changes with age & in #NeurodegenerativeDisease @plosbiology.org 🧪 plos.io/46AEURS

Genetic foundations of interindividual neurophysiological variability Individual brain activity profiles are shaped by lifelong genetic influences.

🧬🧠 Our latest study shows that individual brain dynamics are partly written in our genes. We found that heritable neurophysiological traits align with adult cortical gene expression and psychological function.

www.science.org/doi/10.1126/...

@theneuro.bsky.social @mcgill.ca

New paper in Imaging Neuroscience by Nikhil Bhagwat, Yu-Fang Yang, et al:

Challenging the status quo: A guide to open and reproducible neuroimaging for early career researchers

doi.org/10.1162/IMAG...

Benchmarking methods for mapping functional connectivity in the brain - Nature Methods In this Analysis, Liu et al. benchmark more than 200 pairwise statistics for functional brain connectivity in tasks such as hub mapping, distance relationships, structure–function coupling and behavio...

An Analysis of 200 pairwise statistics for functional brain connectivity in tasks such as hub mapping, distance relationships, structure-function coupling and behavior prediction highlights their effectiveness for neurophysiological applications.

www.nature.com/articles/s41...

New: Energy use shapes brain organization and development. We use gene expression maps from the @alleninstitute.bsky.social Human Brain Atlas to map the main energy metabolism pathways in the brain. Led by @moohebatpe.bsky.social @misicbata.bsky.social @goliashf.bsky.social and Justine Hansen 🧵

Cerebral blood perfusion across biological systems and the human lifespan | doi.org/10.1101/2025...

How does blood perfusion map onto canonical features of brain structure and function? @asafarahani.bsky.social investigates ⤵️

Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health Major mental disorders are increasingly understood as disorders of brain development. Large and heterogeneous samples are required to define generalizable links between brain development and psychopat...

(1/18) Now out on BioRxiv‼️ Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health | doi.org/10.1101/2025...

Funded by National Institute of Mental Health (NIMH)

A data-driven latent variable approach to validating the research domain criteria framework - Nature Communications Refining the Research Domain Criteria (RDoC) framework, a data-driven analysis of task fMRI contrast maps shows a bifactor model improves fit and suggests splitting the cognitive systems domain to bet...

New from Manish Saggar: A data-driven latent variable approach to validating the research domain criteria framework www.nature.com/articles/s41...

Synaptome architecture shapes regional dynamics in the mouse brain | www.biorxiv.org/content/10.1...

Led by Justine Hansen

Big news: there are all sorts of different synapse types in the brain 👀‼️⤵️

Previous work showed that in controlled simulated settings, the spin test does not perfectly control for false positives. In my recent pre-print, we explored why this is the case!

As always, the code to reproduce results + figures is available here: github.com/netneurolab/...

We find that neuropeptides act as a regulatory backbone of brain function through their slow, sustained scale of activity… also, we sample neuropeptide genes from sharks, frogs, chickens, and, my favourite, platypi!

Check it out if you’re looking for a read during the holiday break.

Hi Bluesky, my first PhD project is finally out!

Cells in our bodies can talk to each other in multiple chemical languages, one of the better known being neurotransmitters. Here, we extensively looked at a language that also has its origin in the nervous system — neuropeptides.

Test, test