Estimated Single Year Loss of NIH Funding if 15% Indirect Cost Rate is Imposed
Based on analysis of 2024 NIH funding data. Sums are totals of losses in funding to programs if indirect costs had been capped at 15%
Helpful table to determine how much your University or health system is set to lose if the NIH indirect cap is suddenly lowered to 15%. For SJSU it is $374k which is on the smaller end but devastating considering our other budget issues. datawrapper.dwcdn.net/l0ZqA/8/
09.02.2025 16:24 — 👍 213 🔁 130 💬 15 📌 39
Constructing polymorphonuclear cells: chromatin folding shapes nuclear morphology
Immune cell fate decisions are regulated, at least in part, by nuclear architecture. Here, we outline how nuclear architecture instructs mammalian polymorphonuclear cell differentiation. We discuss how in neutrophils loop extrusion mechanisms regulate the expression of genes involved in phagocytosis and shape nuclear morphology. We propose that diminished loop extrusion programs also orchestrate eosinophil and basophil differentiation. We portray a new model in which competitive physical forces, loop extrusion, and phase separation, instruct mononuclear versus polymorphonuclear cell fate decisions. We posit that loop extrusion programs instruct the spatial organization of cytoplasmic organelles, including neutrophil granules, mitochondria, and endoplasmic reticulum. Finally, we suggest that changing loop extrusion programs might allow the engineering of new nuclear shapes and artificial cytoplasmic architectures.
www.cell.com/trends/immun... Interesting article on nuclear architecture and mammalian PMN cells.
16.12.2024 05:39 — 👍 7 🔁 5 💬 0 📌 0
Discovery Stack Pilot: A Bold Experiment
https://bit.ly/DiscoveryStackHome
Tired of traditional peer review?
Join the Discovery Stack Pilot study to help reshape scientific publishing!
Contribute as a Reviewer or an Author.
Learn more here: bit.ly/DiscoverySta...
#ScienceRevolution #PeerImprovement #DiscoveryStackPilot #immunosky
13.12.2024 23:16 — 👍 14 🔁 10 💬 1 📌 1
Sorry to hear that. A huge loss to the science community and patients.
14.12.2024 01:19 — 👍 1 🔁 0 💬 0 📌 0
Regulation of human interferon signaling by transposon exonization
Transposable element exonization can yield functional protein isoforms as seen for primate-specific IFNAR2.
I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪
12.12.2024 18:56 — 👍 154 🔁 74 💬 12 📌 7
A ‘Second Tree of Life’ Could Wreak Havoc, Scientists Warn (Gift Article)
Research on so-called mirror cells, which defy fundamental properties of living organisms, should be prohibited as too dangerous, biologists said.
Over 30 prominent scientists call for a ban on the creation of a "mirror cell"--a microbe made of molecules that are mirror images of their natural forms. It could cause a mind-boggling global disaster. Here's my story [gift link] 🧪https://nyti.ms/3OUCXp6
12.12.2024 20:04 — 👍 1205 🔁 496 💬 95 📌 204
Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer - Nature
Dietary fructose enhances tumour growth in animal models of melanoma, breast cancer and cervical cancer indirectly via metabolite transfer.
Delighted for my first Bluesky post to be in celebration of the work of Ronnie (@nightscientist.bsky.social) — can’t say enough about his talent & creativity! If you’re interested in the link between dietary fructose and cancer, check out his paper.
#metabolomics
www.nature.com/articles/s41...
05.12.2024 13:41 — 👍 94 🔁 22 💬 4 📌 4
Mind blown🤯
Just playing around with Google's NotebookLM.
notebooklm.google
You upload a PDF of your favourite paper and it spits out a great podcast 🎧
Enjoy a 60s snippet about our recent work in Nature on γδ T cells.
The level of understanding is amazing!
Paper: www.nature.com/articles/s41...
19.11.2024 13:31 — 👍 24 🔁 6 💬 4 📌 6
美国各州平均预期寿命，寿命低的也是集中在“圣经带”。
28.11.2024 01:29 — 👍 93 🔁 10 💬 5 📌 2
MIT BE PhD Student
Stark Lab 🧬
We study how micro-environmental and epigenetic mechanisms drive cancer cells into dormancy. We seek to control this biology to prevent and treat metastasis. https://einsteinmed.edu/faculty/16974/julio-aguirre-ghiso
Mom. Behavioral Scientist. Psychologist. Professor. Musician. Guitarist.
Advocating progress on #PancreasCancer, #BRCA, support for carers. Partner survived #PDAC 8+ yrs at MSKCC. Law (JD); science, & the sea. #StandUpForScience #PancreaticCancer
Childhood Cancer II Translational cancer nanomedicine II underwater photographer
How does cell size affect stem cell function?
Assistant Professor at Helsinki University 🇫🇮 and Karolinska Institutet 🇸🇪 StemCellSIZE - ERC_Research. Alumni @MIT @ETH
http://lengefeldlab.com
Computer scientist at OncoProteomics Lab, Amsterdam UMC, the Netherlands; visiting scholar at Vietnam National University, Hanoi; working on mass spectrometry-based proteomics data analysis and biomedical applications.
Biomedical Scientist @ HYMS | Prostate & Breast Cancer | Diagnosis | Prognosis | Endo180-CD147 | EMT Bio-Switch | Basement Membrane Stiffness | Aging | ECM & MMPs | Cellular Mechanisms of Metastasis | Full Time Prince Fam Since 1984 | Love4OneAnother | 🏳️🌈
Head of Unit @SanRaffaele Milan, Italy | Past Director, Div. Genetics and Cell Biology | Alumna @JHMI, Baltimore, USA | Marie Curie Excellence Team leader | ERCAdvG
Cell Biologist with interest in renal disorders #PKD #Cilia #Cancermetabolism
www.rummanchowdhury.com
www.humane-intelligence.org
CEO & co-founder, Humane Intelligence
US Science Envoy for AI (Biden Administration)
Obama appointee at DOJ/DHS. Litigator for Speaker Pelosi and Jan. 6 Committee. NYC born and bred. Yankee Stadium 🌭 vendor. Wannabe historian. Dad joker.
Personal account. Personal views. Frank G. Millard Professor of Law, University of Michigan Law School & Arlene Susan Kohn Professor of Social Policy, University of Michigan Ford School of Public Policy. Former General Counsel, HHS and OMB.
Prof & Lab Head in NYC. 100% research: cell division, genome integrity, cancer.
Curious to a fault. Also πολύτροπος. Talking here for me alone. I listen to the finest worksong. Like/repost = bookmark/news, not agreement/endorsement.
Washington University School of Medicine Professor | Diabetes Researcher | Stem Cell Biologist | Bioengineer | Inventor | STEM Educator | Former MIT & Harvard | Former Biotech VP | https://sites.wustl.edu/millmanlab/
Organic Chemistry/ Peptides/Pharmaceutical
Google Scholar: https://scholar.google.com/citations?hl=en&user=kx4ua4MAAAAJ&view_op=list
ORCID ID: https://orcid.org/0009-0004-2961-2649
The Lyon-Marseille Center of Excellence in Pediatric Oncology Research (PEDIACRIEX23) - focusing on developmental alterations of #ChildhoodCancers for better care and prevention #Medsky #Science
Tries to understand the cellular response against Mtb and improve antiTB drugs delivery. @inserm @InstitutPasteurLille France
Full Professor, Physical Activity, Exercise Physiology, Biomechanics, Aging, and Optimization of Neuromuscular Performance. Public University of Navarra (Spain)
Director of Finance, Membership and Publishing at the British Society for Immunology (BSI), also Treasurer/Trustee of Applied Microbiology International (AMI). Dad who loves science and sports (especially #immunology and #taekwondo) All views are my own.
