Guocan Wang

Estimated Single Year Loss of NIH Funding if 15% Indirect Cost Rate is Imposed Based on analysis of 2024 NIH funding data. Sums are totals of losses in funding to programs if indirect costs had been capped at 15%

Helpful table to determine how much your University or health system is set to lose if the NIH indirect cap is suddenly lowered to 15%. For SJSU it is $374k which is on the smaller end but devastating considering our other budget issues. datawrapper.dwcdn.net/l0ZqA/8/

09.02.2025 16:24 — 👍 211    🔁 130    💬 14    📌 38

Constructing polymorphonuclear cells: chromatin folding shapes nuclear morphology Immune cell fate decisions are regulated, at least in part, by nuclear architecture. Here, we outline how nuclear architecture instructs mammalian polymorphonuclear cell differentiation. We discuss how in neutrophils loop extrusion mechanisms regulate the expression of genes involved in phagocytosis and shape nuclear morphology. We propose that diminished loop extrusion programs also orchestrate eosinophil and basophil differentiation. We portray a new model in which competitive physical forces, loop extrusion, and phase separation, instruct mononuclear versus polymorphonuclear cell fate decisions. We posit that loop extrusion programs instruct the spatial organization of cytoplasmic organelles, including neutrophil granules, mitochondria, and endoplasmic reticulum. Finally, we suggest that changing loop extrusion programs might allow the engineering of new nuclear shapes and artificial cytoplasmic architectures.

www.cell.com/trends/immun... Interesting article on nuclear architecture and mammalian PMN cells.

16.12.2024 05:39 — 👍 6    🔁 5    💬 0    📌 0

Discovery Stack Pilot: A Bold Experiment https://bit.ly/DiscoveryStackHome

Tired of traditional peer review? 

Join the Discovery Stack Pilot study to help reshape scientific publishing! 

Contribute as a Reviewer or an Author.

Learn more here: bit.ly/DiscoverySta...
#ScienceRevolution #PeerImprovement #DiscoveryStackPilot #immunosky

13.12.2024 23:16 — 👍 14    🔁 10    💬 1    📌 1

Sorry to hear that. A huge loss to the science community and patients.

14.12.2024 01:19 — 👍 1    🔁 0    💬 0    📌 0

Regulation of human interferon signaling by transposon exonization Transposable element exonization can yield functional protein isoforms as seen for primate-specific IFNAR2.

I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪

12.12.2024 18:56 — 👍 156    🔁 74    💬 12    📌 7

A ‘Second Tree of Life’ Could Wreak Havoc, Scientists Warn (Gift Article) Research on so-called mirror cells, which defy fundamental properties of living organisms, should be prohibited as too dangerous, biologists said.

Over 30 prominent scientists call for a ban on the creation of a "mirror cell"--a microbe made of molecules that are mirror images of their natural forms. It could cause a mind-boggling global disaster. Here's my story [gift link] 🧪https://nyti.ms/3OUCXp6

12.12.2024 20:04 — 👍 1202    🔁 492    💬 94    📌 201

Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer - Nature Dietary fructose enhances tumour growth in animal models of melanoma, breast cancer and cervical cancer indirectly via metabolite transfer.

Delighted for my first Bluesky post to be in celebration of the work of Ronnie (@nightscientist.bsky.social) — can’t say enough about his talent & creativity! If you’re interested in the link between dietary fructose and cancer, check out his paper.
#metabolomics

www.nature.com/articles/s41...

05.12.2024 13:41 — 👍 94    🔁 22    💬 4    📌 4

Mind blown🤯

Just playing around with Google's NotebookLM.
notebooklm.google

You upload a PDF of your favourite paper and it spits out a great podcast 🎧

Enjoy a 60s snippet about our recent work in Nature on γδ T cells.

The level of understanding is amazing!

Paper: www.nature.com/articles/s41...

19.11.2024 13:31 — 👍 24    🔁 6    💬 4    📌 6

美国各州平均预期寿命，寿命低的也是集中在“圣经带”。

28.11.2024 01:29 — 👍 93    🔁 10    💬 5    📌 2

旧金山湾区四个刚上大学的学生回家过感恩节，开特斯拉皮卡出去玩，失控撞到路边的树，当即起火，没法扑灭，有一个被路人冒险救出、严重烧伤，另三人在车里出不来被活活烧伤。特斯拉皮卡没卖出多少，事故不断，开这种车就是害人害己，对别的车、行人都是严重威胁，应该禁止上路。

28.11.2024 02:07 — 👍 137    🔁 23    💬 23    📌 1