Tereza Kadavá

🔬 For more, delve into this paper published in Molecular & Cellular Proteomics ( @asbmbjournals.bsky.social): www.mcponline.org/article/S153....

Congratulations to @tkadava.bsky.social, @hecklab.bsky.social and colleagues on this fascinating work!

This 3D visualization of C4BP was created by Hecklab (Albert Heck) in collaboration with Sensu.health. C4BP uses its eight “legs” to catch proteins related to inflammation, stopping further immune response.

C4BP-C4b complexes visualized by high-speed atomic force microscopy.

#Halloween Trivia 🕸️ Did you know human blood contains spider-shaped proteins that help regulate the innate immune response?
🕷️Discover how C4BP uses its eight “legs” to catch proteins and control inflammation: www.asbmb.org/asbmb-....
#Immunology #MolCellProt #MassSpec

Having a great time at msandm2025.org with a great bunch of people interesting in visualizing biomolecules, together with my co-chairs @joostsnijder.bsky.social @vixklen.bsky.social & Kyle Fort. Learning so much from all posters & lectures. We thanks all participants for joining us in Utrecht.

Excited to see the C4BP in action. 🕷️
Check out the short movie by Sensu about our work from @hecklab.bsky.social lab.

Last week to apply!

Thanks Johannes!

We show that C4BP has two distinct binding modes, either involving a single “spider leg” or the entire spider-like structure wrapping around the target.
Thanks to everyone involved!
@victoryin.bsky.social, @hecklab.bsky.social, Jürgen, Johannes, Maryam, and Leendert

Structural Insights into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-binding Protein Complexes with C4b and SAP C4b-binding protein (C4BP) is an innate immune inhibitor found in serum. Human C4BP adopts spider-like higher-order structures (HOS) formed by disulfide-linked C4BPα and C4BPβ chains that non-covalent...

🕷️ Spiders from our blood 🕷️
Check out our new paper from @hecklab.bsky.social describing how the spider-like immune regulator C4BP interacts with its native binding partners.
🔗 www.mcponline.org/article/S153...
#MassSpec #StructuralBiology

Free structural MS hands-on workshop @ BIOCEV (CZ)

📅 Sept 15–19, 2025

For PhDs, postdocs & undergrads (CZ/SK)

HDX-MS, native MS, cross-linking, high-res MS, data processing

Apply by July 31 → bit.ly/3HNyzIg

@spidocs.bsky.social @mbuavcr.bsky.social @ciisbinstructcz.bsky.social

Are you looking forward to attending #EuPA2025 in beautiful Saint-Malo? Get ready for an enriching experience in extraordinary #proteomics!

🗓️ Mark your calendar for the SCIEX lunch symposium, taking place on Wednesday, June 18!

🔗 Full show agenda 👉 bit.ly/3HcA6Hw

#SkepticsWelcome #ZenoTOF8600

It has been nice to contribute to this nice piece of work together with @tkadava.bsky.social and @mattevilab.bsky.social

Spiders from our blood 🕷️
Excited to present our work with @hecklab.bsky.social at #ASMS2025 WP 611.

Excited to share our new preprint on archaeal proteases boosting reads in de novo antibody sequencing!

Team effort with @tkadava.bsky.social @tshamorkina.bsky.social and @hecklab.bsky.social

Check out our new preprint on combining archeal proteases with hybrid fragmentation to streamline de novo antibody sequencing!
Joined effort with @lperezpaneda.bsky.social, @tshamorkina.bsky.social, and @hecklab.bsky.social

Deep Coverage and Extended Sequence Reads Obtained with a Single Archaeal Protease Expedite de novo Protein Sequencing by Mass Spectrometry www.biorxiv.org/cont...

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#proteomics #prot-preprint