@mattgirgenti.bsky.social
Assistant Prof YalePsych and DeptVetAffairs. Single-cell, Genomics, Neuroscience, Psychiatric Genetics. Dad of 2. MtG collector. Opinions are mine
The Snell lab is seeking a Postbaccalaureate researcher and Postdoctoral associate to join our team. More details here:
www.snelllab.org/contact-2
A summary of NIH Director Jay Bhattacharya's comments during his visit to UAB today for a town hall style presentation:
-Important for scientific work addressing our nation's health problems to be done in the same communities where those problems are concentrated
Our recent overview of human stem cell models for studying neuropsychiatric disorders (including their limitations and future directions) is now openly available @annualreviews.bsky.social of Neuroscience
With the great @rebeccalevymdphd.bsky.social
Meet MapMyCells! This tool saves neuroscientists precious time by comparing their data to massive, high-quality reference datasets, including our whole mouse brain multi-omics atlas and the Seattle Alzheimer’s Disease Brain Cell Atlas.
🧠📈 portal.brain-map.org/atlases-and-...
#studyBRAIN
Special thanks to all colleagues and coauthors. And support from @yaleschoolofmed.bsky.social @kavliatyale.bsky.social @wutsaiyale.bsky.social
18.06.2025 16:53 — 👍 1 🔁 0 💬 0 📌 0This is the first time that single cell approaches were used to link genetic, chromatin, and transcriptomic dysregulation in PTSD and MDD to exhaustively characterize the molecular landscape of stress disorders.
18.06.2025 16:53 — 👍 0 🔁 0 💬 1 📌 0
Finally, we fine mapped credible GWAS loci for PTSD within specific cell types. We identified chromatin looping between the MAD1L1risk loci and the nearby gene ELFN1 within inhibitory neurons. ELFN1 dysregulation is likely at the root of many of the disruptions in SST communication in the cortex.
18.06.2025 16:53 — 👍 0 🔁 0 💬 1 📌 0
We mapped chromatin accessibility changes in both the PTSD and MDD brain and identified TF binding changes in disease- specific CREs.
18.06.2025 16:53 — 👍 0 🔁 0 💬 1 📌 0
We also found important differences between PTSD and MDD- specifically related to microglia communication. PTSD microglia communication with other cell types was suppressed while MDD increased communication- specifically through the SP1 pathway.
18.06.2025 16:53 — 👍 0 🔁 0 💬 1 📌 0
We created a large spatial transcriptomic dataset to validate our findings, but more importantly we were able to capture nuclear and soma transcriptomic differences.
18.06.2025 16:53 — 👍 0 🔁 0 💬 1 📌 0
We used an animal model of traumatic stress to mechanistically define decreased inhibitory neuron signaling through GABA signaling to GABRA5, GABBR1, GABRB1 and GABRG1 receptors on excitatory neurons.
18.06.2025 16:53 — 👍 0 🔁 0 💬 1 📌 0
The most affected cell types were inhibitory neurons, endothelial cells and microglia. We found that PTSD inhibitory neurons- specifically SST+ had decreased activity and transcription levels.
18.06.2025 16:53 — 👍 1 🔁 0 💬 1 📌 0
We examined the transcriptomic and chromatin dynamics of 111 donors with PTSD, MDD or healthy controls at single cell resolution (>2M nuclei). We identified >60 transcriptomic cell subtypes and >1000 DEGs across cell types.
18.06.2025 16:53 — 👍 0 🔁 0 💬 1 📌 0
Very proud of our new #SingleCell work on #PTSD and #MDD out in @nature.com today.
Paper: www.nature.com/articles/s41...
News and views: www.nature.com/articles/d41...
Press: medicine.yale.edu/news-article...
Data: doi.org/10.5281/zeno...
Code: github.com/mjgirgenti/P...
Faculty member Aaron Kuan presenting his talk in front of several rows of department members.
Students and postdocs presenting their work at the poster session.
Round table of smiling trainees (despite the clouds), with the Long Island Sound in the background.
Photo of the graduate students present at the retreat, with the beach in the background.
We recently celebrated our annual Neuroscience Retreat🧠👥
Thank you so much to everyone who came and made it such a memorable retreat full of science, collaboration, and community🤝🤗📸👇
Flyer for 05/12/2025 seminar by Michael Ward, MD, PhD, showing his headshot, talk title "The Hidden Biology of Neuronal Lysosomes in Health and Disease", and location room 180 at 100 College St.
Join us today at noon 🕛 for a seminar by @michael-e-ward.bsky.social, MD, PhD, from NIH/NINDS, on neuronal lysosomes in health and disease.
Thank you to @yaleneuro.bsky.social's Shaul Yogev and @sugarrayy.bsky.social for hosting! We hope to see you there!
In a new @yale.edu study, researchers led by @mattgirgenti.bsky.social from #YalePsychiatry used a comprehensive multi-omic approach to analyze postmortem brain 🧠 genomics and investigate the molecular differences 🧬 in PTSD and major depressive disorder 🔍
09.05.2025 16:00 — 👍 3 🔁 3 💬 0 📌 0We identified shared and unique brain molecular dysregulations between the two disorders across genomic levels.
This work was funded by @NIDA and the Yale/NIDA Neuroproteomic Center
@yaleschoolofmed.bsky.social @wutsaiyale.bsky.social
Excited to share our latest study of the PTSD prefrontal cortex out @GenomeMedicine. rdcu.be/ejZ3T
Our systems biology approach established a brain multi-omic, multi-region analysis comprising individuals with PTSD and MDD
Hot off the science presses! The largest map of the brain's wiring and activity to date is featured on the cover of @nature.com.
🧠📈 Check out 'Cortex in Context' at: www.nature.com/immersive/d4...
Obsessed with this photo I took of a California Condor at the Oregon Zoo looking out into the rain majestically 🌧️
10.04.2025 18:37 — 👍 12059 🔁 937 💬 290 📌 32
Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🧪
Led by Ling-Xiao Shao and @ItsClaraLiao
Funded by @NIH @NIMHgov
📄 Read in @nature.com - www.nature.com/articles/s41...
1/12
