Katerina Akassoglou - Akassoglou Lab

#AAIC25 day 2 in full swing here in Toronto!! Fascinating morning sessions, and a fantastic plenary talk by @akassogloulab.bsky.social on neurovascular interaction mechanisms!!! Now another plenary talk about heterogeneous tauopathy presentation by the eminent Prof Maria Grazia Spillantini!!

Thank you very much for your kind words!

#AAIC25 attendees, don’t miss today's plenary session at 11 a.m., featuring

🟣 Maria Grazia Spillantini, Ph.D., Professor, Molecular Neurology in the Clinical School, University of Cambridge.

🟣 @akassogloulab.bsky.social‬, Professor, Department of Neurology, University of California, San Francisco

Spread the word: The European Center for Angioscience @uniheidelberg.bsky.social continues to grow: We have openings for 2 additional Junior Group Leader positions. Get in touch with us if you are ready to start your own lab. See also corresponding ad in @nature.com: www.nature.com/naturecareer...

Zhaoqi Yan Named a 2025 Warren Alpert Distinguished Scholar Gladstone researcher receives prize to study blood-brain barrier dysfunction and its impact on neurological disease.

Gladstone scientist Zhaoqi Yan received an award for postdocs who show exceptional creativity in neuroscience. He will use it to study blood-brain barrier dysfunction and its impact on neurological disease.

@akassogloulab.bsky.social

bit.ly/3EZT4R9

Insightful Review by Gabriele De Luca at @ox.ac.uk discussing BBB permeability and fibrin deposition driving neuroinflammation, gliosis & neurodegeneration as a shared pathogenic cascade & therapeutic target among neurological diseases.
journals.sagepub.com/doi/10.1177/...

Great Session today at 2025 Annual Meeting of the American Society for Experimental Neurotherapeutics (ASENT) on "Immunotherapy of Neurodegenerative Diseases". A tour-de-force talk by V. Wee Yong on extracellular matrix & remyelination. Thank you to the organizers & all for joining us!

Congratulations to winners of The Brain Prize 2025!
Professors @michellemonje.bsky.social, @stanfordmedicine.bsky.social and @hhmi.org Investigator, and Frank Winkler, Heidelberg University Hospital, have pioneered the field of Cancer Neuroscience.

Learn more: brainprize.org/winners/canc...

What We Know About Covid’s Impact on Your Brain Scientists worry that persistent cognitive issues caused by Covid signal that a surge in dementia cases and other mental conditions is on the horizon.

Scientists worry that persistent cognitive issues caused by Covid signal that a surge in dementia cases and other mental conditions is on the horizon.
Gift link to my updated explainer on what we know about Covid’s impact on the brain ⬇️
tinyurl.com/yrpwkf2n

Congrats to Zhaoqi Yan postdoc fellow @akassogloulab.bsky.social for his selection for the 2025 Warren Alpert Distinguished Scholar Fellowship! Grateful to Warren Alpert Foundation for supporting Zhaoqi’s exciting research on blood-brain barrier & neurodegeneration! www.warrenalpertfoundation.org

NIH funding freeze stalls applications on $1.5 billion in medical research funds The National Institutes of Health had to stop considering new grant applications, delaying funding for research into diseases ranging from heart disease and cancer to Alzheimer's and allergies.

The National Institutes of Health had to stop considering new grant applications, delaying funding for research into diseases ranging from heart disease and cancer to Alzheimer's and allergies.

Revealed: NIH research grants still frozen despite lawsuits challenging Trump order The Trump administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo.

Almost all grant-review meetings under Trump 2.0 remain suspended at the US National Institutes of Health (NIH), preventing the world’s largest public funder of biomedical research from spending much of its US$47 billion annual budget.


https://go.nature.com/4gM6oW4

The neuroimmune connectome in health and disease - Nature A review of studies on communication between the nervous and immune systems redefines the neuroimmune connectome with a focus on health and disease, and discusses how the latest techniques can advance...

The neuroimmune connectome in health and disease
www.nature.com/articles/s41...

Andrew Park & Lauren Le undergraduates @ucberkeleyofficial.bsky.social joined our lab @gladstoneinst.bsky.social for their research training! Grateful to all members of my lab for supporting the training of 21 amazing undergrads todate & their enthusiasm introducing young scientists to research!

Congrats to Zhaoqi Yan & Jae Kyu Ryu for receiving the 2024 Gladstone Award for Scientific Excellence, to Zhaoqi for the Dormal Best Paper Prize & Pilar Alzamora for the GIND Award of Excellence! Thank you gladstoneinst.bsky.social for recognizing the scientific achievements of this amazing team!

Congratulations to Hisao Miyajima postdoctoral fellow @akassogloulab.bsky.social @gladstoneinst.bsky.social and UCSF for being awarded a NMSS Postdoctoral Fellowship to study mechanisms of progression in Multiple Sclerosis. So proud of his accomplishment!

🚨 CNS barriers scientists...come join us for #cshlbbb 2025! Submit your abstracts by January 24th...we pick MANY talks from abstracts - we look forward to seeing you in April!

An elegant study by Katerina Akassoglou and colleagues
has illuminated our understanding of the role of fibrin (component of blood clots), SARS-CoV-2, and brain inflammation in Covid/Long Covid.
A new Ground Truths podcast, w/transcript. Open-access.
erictopol.substack.com/p/katerina-a...

National MS Society on LinkedIn: Breakthroughs in MS research are occurring every year. Dr. Katarina… Breakthroughs in MS research are occurring every year. Dr. Katarina Akassoglou, winner of the Barancik Prize in 2019, is researching aids against…

Grateful to the National Multiple Scerosis Society for supporting new ideas for basic research in neuroimmunology leading to new therapies for MS & neurological diseases. www.linkedin.com/posts/nation...

Our lab at Yale U/Wu Tsai Institute has a postdoctoral position on neurodegeneration, neuro-glial-vascular biology using 2photon, calcium/voltage imaging, gene editing,transcriptome/proteome, 3D EM, translational neurosci/chemistry. Email me if interested. Forward to those interested pls

The pathobiology of neurovascular aging As the population ages, neurovascular pathologies have become leading causes of death and disability. Santisteban and Iadecola review data showing that neurovascular aging not only reduces cerebral blood flow but also impairs protein clearance, immune function, and neurotrophic homeostasis, thereby increasing the risk of stroke, vascular dementia, and Alzheimer’s disease.

A really 🔥 topic ! "The pathobiology of neurovascular aging" www.cell.com/neuron/fullt... #cerebrovascular

Fibrin drives thromboinflammation and neuropathology in COVID-19 - Nature Fibrin drives inflammation and neuropathology in SARS-CoV-2 infection, and fibrin-targeting immunotherapy may represent a therapeutic intervention for patients with long COVID.

🧠 How COVID-19 impacts the brain

Researchers found that blood clots linked to COVID-19 can cause inflammation and brain damage.

A new antibody treatment targeting these clots could help reduce long-term effects seen in long COVID.

🔗 www.nature.com/articles/s41...

#SciComm #COVID19 🧪

Interested in using functional genomics to understand the brain in health and disease?

Check out our Gordon research conference below! Slots for posters and short talks are still available! Deadline March 9th

www.grc.org/functional-g...

Neurovascular dysfunction in psychiatric disorders: Underlying mechanisms and therapeutic approaches The neurovascular unit (NVU) is present in both brain and retinal barriers and consists of endothelial cells, basement membrane, pericytes, glial cells (astrocytes and microglia) and neurons. Barrier...

Nice review highlighting the associations between neuropsychiatric conditions and #cerebrovascular deficits doi.org/10.1111/eci.... #BloodBrainBarrier #Psychiatry

Wishing Lucas all the best with his treatment and sending your family strength and support. We are here for you!

YouTube video by ASPETpharmacology ASPET 2024 Pharmacia ASPET Award - Katerina Akassoglou, PhD, FASPET

Thank you ASPET for a new Video highlighting our research at the Akassoglou Lab recently recognized by the Pharmacia-ASPET Award!
www.youtube.com/watch?v=WOs1...

Advances in Biomarker Discovery: From Disease Detection to Cure This article examines some of the latest advances in biomarker discovery in the fields of cancer and neurodegenerative and infectious diseases and the technologies that are driving these discoveries.

Insightful article on biomarkers & new therapies in cancer & neurological diseases. It was a pleasure discussing fibrin as a therapeutic target & biomarker.
Biomarker Discovery: Revolutionizing Disease Management | Technology Networks www.technologynetworks.com/diagnostics/...

Excited to chair the #Neuroimmunology Session @ascbiology.bsky.social EMBO #CellBio2024 Meeting. Join us if you are in San Diego!
plan.core-apps.com/ascbembo2024...

Targeting a clotting protein to treat neonatal brain bleeds Researchers discovered that a blood clotting protein, fibrinogen, harms brain development during bleeds in preterm infants.

Excellent interview by Mark Petersen @ucsfchildrens.bsky.social on his research on brain bleeds in preterm babies “These interventions could change the course of their life. Basic science is what drives new discoveries, so I wanted to be a part of that” #ProudofAlumni
tinyurl.com/589mbrd3